Kidney Supplements?

[Bleed]

No, sir. We do not do it that way here.

As you should know by know staying on point and just replying to the question the OP made. Is not the way it is done here much of the time.

 

[Andro308]

Thank you for the supplement recommendations!!!

 

[DOGGCRAPP]

Do you know how Ive told you guys repeatedly not to use that NUSAPURE company on Amazon who is spending huge amounts of money on advertising and making a killing on there? I kept seeing people use that brand and I would view their bloodwork and I know what astragalus does for kidney values....Ive seen hundreds upon hundreds of bloodwork now so i know the effect....and this NUSAPURE would do absolutely nothing. So i just came across today some assays on 10 companies with a certain very popular ingredient (one that NUSAPURE is making a killing on with Amazon).... It was supposed to have 400mg in it.....look what it had in it ...NOTHING! Talk about a freaking scam.....stay away from that company and all its products.

 

[69cyclerider]

I use the NOW brand and I know that works well. When I use it I have no protein leaking into my urine and when I don't use it I have protein leaking.

 

[MR. BMJ]

Do you know how Ive told you guys repeatedly not to use that NUSAPURE company on Amazon who is spending huge amounts of money on advertising and making a killing on there? I kept seeing people use that brand and I would view their bloodwork and I know what astragalus does for kidney values....Ive seen hundreds upon hundreds of bloodwork now so i know the effect....and this NUSAPURE would do absolutely nothing. So i just came across today some assays on 10 companies with a certain very popular ingredient (one that NUSAPURE is making a killing on with Amazon).... It was supposed to have 400mg in it.....look what it had in it ...NOTHING! Talk about a freaking scam.....stay away from that company and all its products.

How did the other brands test out?

 

[DOGGCRAPP]

How did the other brands test out?

3 of the 10 were near claim, 1 was half the mg of the claim, 6 yes 6 were either non detectable or had trace amounts that were 1/20 to 1/40 of the mg claimed

 

[MR. BMJ]

3 of the 10 were near claim, 1 was half the mg of the claim, 6 yes 6 were either non detectable or had trace amounts that were 1/20 to 1/40 of the mg claimed

Thanks, just seen your answer on FB

If you can't mention the top 3, was one of them the brand you've recommended frequently?

And, not sure if you can answer this one, but the brand in post #24, was it tested?

Figured i'd ask since you might still be on, lol

 

[suppdude]

Thanks, just seen your answer on FB

If you can't mention the top 3, was one of them the brand you've recommended frequently?

And, not sure if you can answer this one, but the brand in post #24, was it tested?

Figured i'd ask since you might still be on, lol

Just use Vitamin Shoppe brand Astragalus

 

[mike036]

Just use Vitamin Shoppe brand Astragalus

I have done bloodwork twice using Vitamin Shoppe astragalus and both times my egfr was improved. The first time I tried astragalus I used Nusapure and my egfr actually went down. DO NOT USE NUSAPURE

 

[Fluffy_XL]

I wonder why Astragalus is still being hyped that much.

One of you guys posted on page 1 that his eGFR (which doesn't mean much in the first place) increased a bit on Astragalus.
Nice so far but then he stopped taking it and the eGFR dopped to former levels.
So what does that mean? Is it a longterm improvement or rather a temporary cover-up of bad values?

 

[mike036]

I wonder why Astragalus is still being hyped that much.

One of you guys posted on page 1 that his eGFR (which doesn't mean much in the first place) increased a bit on Astragalus.
Nice so far but then he stopped taking it and the eGFR dopped to former levels.
So what does that mean? Is it a longterm improvement or rather a temporary cover-up of bad values?

It’s a fairly cheap product. If someone stops taking their cholesterol medication or blood pressure medication their conditions will go back to the way it was before medication or get worse

 

[MyNameIsJeff]

I wonder why Astragalus is still being hyped that much.

One of you guys posted on page 1 that his eGFR (which doesn't mean much in the first place) increased a bit on Astragalus.
Nice so far but then he stopped taking it and the eGFR dopped to former levels.
So what does that mean? Is it a longterm improvement or rather a temporary cover-up of bad values?

Here's why:

Effective treatment of idiopathic membranous nephropathy continues to elude investigators.1 In a previous report published in the American Journal of Kidney Diseases,2 we described a woman with nephrotic syndrome due to idiopathic membranous nephropathy resistant to cyclosporine and mycophenolate who underwent a complete remission after taking a traditional Chinese remedy containing Astragalus membranaceus (Huang qi), an immunologically active herb native to northern China. She took Astragalus for approximately 1 year, and remission has persisted for the subsequent 4 years. We now report a second patient with idiopathic membranous nephropathy who underwent complete remission of nephrotic syndrome after taking this agent.

A 63-year-old man developed nephrotic syndrome and underwent kidney biopsy in April 2006, which revealed membranous nephropathy. He was treated for idiopathic membranous nephropathy with prednisone and cyclosporine beginning in July 2006. He also received various renin-angiotensin system inhibitors, including angiotensin-converting enzyme inhibitors, angiotensin antagonists, aliskiren, and spironolactone. Over the next 2 years, there was fluctuation in protein excretion (Fig 1) but no remission of proteinuria. On July 23, 2008, he began taking Astragalus (Puritan's Pride, Inc), 15 g daily, after which he experienced complete remission of nephrotic syndrome. He discontinued taking Astragalus on August 6, 2009. His serum creatinine was 0.9 mg/dL (79.56 μmol/L, estimated glomerular filtration rate >59 mL/min/1.73 m2 [>0.98 mL/s/1.73 m2]) when last measured on October 28, 2009. On January 10, 2010, his urine protein-creatinine ratio was 0.2 g/g.

**broken link removed**

BACKGROUND:
Astragalus (Radix Astragali, huang qi) is the dried root of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao or Astragalus membranaceus (Fisch.) Bge. (Family Leguminosae). It is one of the most widely used herbs in traditional Chinese medicine for treating kidney diseases. Evidence is needed to help clinicians and patients make judgments about its use for managing chronic kidney disease (CKD).

OBJECTIVES:
This review evaluated the benefits and potential harms of Astragalus for the treatment of people with CKD.

SEARCH METHODS:
We searched the Cochrane Renal Group's Specialised Register to 10 July 2014 through contact with the Trials' Search Co-ordinator using search terms relevant to this review. We also searched CINAHL, AMED, Current Controlled Trials, OpenSIGLE, and Chinese databases including CBM, CMCC, TCMLARS, Chinese Dissertation Database, CMAC and Index to Chinese Periodical Literature.

SELECTION CRITERIA:
Randomised controlled trials (RCTs) and quasi-RCTs comparing Astragalus, used alone as a crude herb or an extract, with placebo, no treatment, or conventional interventions were eligible for inclusion.

DATA COLLECTION AND ANALYSIS:
Two authors independently extracted data and assessed risk of bias in the included studies. Meta-analyses were performed using relative risk (RR) for dichotomous outcomes and mean differences (MD) for continuous outcomes, with 95% confidence intervals (CI).

MAIN RESULTS:
We included 22 studies that involved 1323 participants, of whom 241 were receiving dialysis treatment. Risk of bias was assessed as high in six studies, and unclear in the remaining 16 studies. Study quality was low overall.Our nominated primary outcomes of time to requirement for renal replacement therapy (RRT) or initiation of dialysis and all-cause mortality were not reported in any of the included studies.Results concerning the effects of Astragalus on kidney function were inconsistent. Astragalus significantly increased CrCl at end of treatment (4 studies, 306 participants: MD 5.75 mL/min, 95% CI 3.16 to 8.34; I² = 0%), decreased SCr (13 studies, 775 participants: MD -21.39 µmol/L, 95% CI -34.78 to -8; I² = 70%) and especially in those whose baseline SCr was < 133 µmol/L in particular (3 studies, 187 participants: MD -2.52 µmol/l, 95% CI -8.47 to 3.42; I² = 0%). Astragalus significantly decreased 24 hour proteinuria at end of treatment (10 studies, 640 participants; MD -0.53 g/24 h, 95% CI -0.79 to -0.26; I² = 90%); significantly increased haemoglobin levels overall (4 studies, 222 participants): MD 9.51 g/L, 95% CI 4.90 to 14.11; I2 = 0%) and in haemodialysis patients in particular (3 studies, 142 participants: MD 11.20 g/L, 95% CI 5.81 to 16.59; I² = 0%). Astragalus significantly increased serum albumin (9 studies, 522 participants: MD 3.55 g/L, 95% CI 2.33 to 4.78; I² = 65%). This significant increase was seen in both dialysis (3 studies, 152 participants): MD 4.04 g/L, 95% CI 1.91 to 6.16; I2 = 72%) and non-dialysis patients (6 studies, 370 participants: MD 3.24 g/L, 95% CI 1.70 to 4.77; I² = 61%). Astragalus significantly decreased systolic blood pressure (2 studies, 77 participants: MD -16.65 mm Hg, 95% CI -28.83 to -4.47; I² = 50%), and diastolic blood pressure (2 studies, 77 participants: MD -6.02 mm Hg, 95% CI -10.59 to -1.46; I² = 0%).Six of 22 included studies reported no adverse effects were observed; while the remaining 16 studies did not report adverse effects.

AUTHORS' CONCLUSIONS:
Although Astragalus as an adjunctive treatment to conventional therapies was found to offer some promising effects in reducing proteinuria and increasing haemoglobin and serum albumin, suboptimal methodological quality and poor reporting meant that definitive conclusions could not be made based on available evidence.

Astragalus (a traditional Chinese medicine) for treating chronic kidney disease - PubMed

Although Astragalus as an adjunctive treatment to conventional therapies was found to offer some promising effects in reducing proteinuria and increasing haemoglobin and serum albumin, suboptimal methodological quality and poor reporting meant that definitive conclusions could not be made based...

www.ncbi.nlm.nih.gov

To investigate the effect of the traditional Chinese herbs Astragali and Angelicae Sinensis (A & As) particle [contains Huangqi (Radix Astragali Mongolica), Danggui (Radix Angelicae Sinensis), Huzhanggeng (Rhizoma Polygoni Cuspidati) and Danshen (Radix Salviae Miltiorrhizae)] on proteinuria in glomerulonephritis patients with stage 2 chronic kidney disease.
Methods
A prospective, multi-center, and randomized controlled clinical trial was performed for 24 weeks. From March 2011 to April 2012, 158 patients from nine hospitals in China participated. They were randomized into the A&As group (79 cases, A&As particle 15.2 g/day) and losartan group (79 cases, losartan 50 mg/day). At each follow-up visit, clinical data including blood pressure, urinalysis, 24-h-urinary protein excretion, serum albumin and serum creatinine were collected.
Results
All 158 patients completed the follow-up. Proteinuria in the losartan group exhibited a biphasic time-dependent decline with a significant steady reduction from baseline to week 12 (P = 0.0014), and a platform level during the remaining 12-week follow-up (P > 0.05). In contrast, there was a continual significant decrease of proteinuria in the A & As group (P < 0.001). When compared with the losartan results, proteinuria in the A & As group from week 16 to week 24 was significantly reduced (P < 0.001). Stable eGFRs and blood pressure were also observed in both groups. Medication side effects were minimal and non-fatal.
Conclusion
For Chinese glomerulonephritis patients with stage 2 chronic kidney disease, therapy with A & As particles may provide effective anti-proteinuria treatment.

Effect of Astragali and Angelica particle on proteinuria in Chinese patients with primary glomerulonephritis

To investigate the effect of the traditional Chinese herbs Astragali and Angelicae Sinensis (A & As) particle [contains Huangqi (Radix Astragali Mongo…

www.sciencedirect.com

Proteinuria is a marker of renal injury, reflecting loss of normal permselecitvity. Further, proteinuria itself has been proposed to contribute to progressive renal injury inflammation [74, 103]. Increased proteinuria is associated with worse prognosis [104]. Whether proteinuria is merely a marker of injury or a contributor to progressive injury has been debated.

Albumin can in vitro in tubular cells increase AngII and in turn upregulate TGF-β receptor expression [105]. However, in most settings, pure albumin per se is not directly injurious. Other filtered components of the urine in proteinuric states, such as oxidized proteins, appear to be more potent in inducing direct injury of tubular epithelial cells and activating proinflammatory and fibrotic chemokines and cytokines. Complement and various lipoproteins are also present in the urine in proteinuric disease states and can activate reactive oxygen species [101, 106]. Proteinuria may thus alter tubule cell function directly, potentially contributing to a more profibrotic phenotype, and also augment interstitial inflammation, in particular by macrophages. Proteinuria may activate many profibrotic pathways through its ability to increase NF-kB, and also by other pathways. These include for instance complement synthesis from tubules [107].

Interventions that are particularly effective in decreasing proteinuria, such as the administration of ACEIs or ARBs, also decrease overall end organ injury. Whether these beneficial effects are dependent on the reduction of proteinuria has not been proven, in that these interventions have multiple parallel effects that may all contribute to the decrease of fibrosis [107].

Mechanisms of progression of chronic kidney disease

Chronic kidney disease (CKD) occurs in all age groups, including children. Regardless of the underlying cause, CKD is characterized by progressive scarring that ultimately affects all structures of the kidney. The relentless progression of CKD is postulated ...

www.ncbi.nlm.nih.gov

 

[MyNameIsJeff]

Objective: To investigate the effects of Astragalus membranaceus on patients with incipient diabetic nephropathy( IDN).Methods: Forty patients with IDN were randomly divided into two groups. The twenty cases in the treated group (Group A) were treated with Astragalus membranaceus injection 20 ml/d (equivalent to Astragalus membranaceus 40 g) in addition to conventional therapy, whereas the 20 cases in the control group(Group B) were treated only with conventional therapy. The levels of urinary endothelin (UET), and albumin were measured before and after treatment. Blood glucose and glycosylated hemoglobulin levels were also measured.Results: After four weeks therapy, the levels of UET and urinary albumin excretion rate. (UAER) in Group A were 39.8 ± 12.7 pg/12h and 37.3 ± 30.4 μg/min respectively as compared with Group B (51.2±12.8pg/12h, 79.6 ± 35.8μg/min respectively, P<0.05, P<0.01 respectively). Compared with the pretreatment level, the UET and UAER values declined significantly in Group A(P< 0.01), but not in Group B(P>0. 05). One month after stopping use of Astragalus membranaceus, the levels of UET and UAER in Group A were still lower than those in Group B, and the difference in the two groups was statistically significant.Conclusion: Astragalus membranaceus might reduce UET and UAER in patients with IDN.

Effects of astragalus membranaceus on urinary endothelin in patients with incipient diabetic nephropathy - Chinese Journal of Integrative Medicine

Objective: To investigate the effects of Astragalus membranaceus on patients with incipient diabetic nephropathy( IDN).Methods: Forty patients with IDN were randomly divided into two groups. The twenty cases in the treated group (Group A) were treated with Astragalus membranaceus injection 20...

link.springer.com

Synthesis of ET-1 by kidney cells is the primary source of urinary ET-1; < 1.0 % of ET-1 in urine derives from the filtered load [13–17]. Thus urinary ET- is a non-invasive surrogate for ET-1 in kidney tissue that avoids the risk and cost associated with immunohistochemical analysis in percutaneous renal biopsy.
[...]
Urine ET-1 is associated inversely [!] with eGFR independent of age, sex and blood pressure in a pilot, cross-sectional study. Potential significance of our findings are that ET-1 may be a novel therapeutic target for slowing progression of kidney disease in ADPKD. Development of orally-active receptor antagonists for ETA and/or ETB receptor is in early stages, but these drugs have been approved recently for treatment of pulmonary artery hypertension and scleroderma-related digital ulcers. Multiple clinical studies point to efficacy of ETA receptor antagonists in diabetic and non-diabetic chronic kidney disease [37, 38]. To our knowledge ETA or ETB antagonists have not been studied in trials of ADPKD. Another possibility is that elevated urinary excretion of ET-1 may be a biomarker of early renal injury. Our findings suggest that additional studies of ET-1 and ET-1 receptor antagonists in ADPKD, particularly longitudinal trials, may be warranted.

Relationship of urinary endothelin-1 with estimated glomerular filtration rate in autosomal dominant polycystic kidney disease: a pilot cross-sectional analysis

The pathogenesis of progressive renal insufficiency in autosomal dominant polycystic kidney disease (ADPKD) is unclear. Evidence from experimental models of ADPKD suggests that elevated endothelin-1 (ET-1) drives cyst growth, renal fibrosis and loss of ...

www.ncbi.nlm.nih.gov

 

[DOGGCRAPP]

Thanks, just seen your answer on FB

If you can't mention the top 3, was one of them the brand you've recommended frequently?

And, not sure if you can answer this one, but the brand in post #24, was it tested?

Figured i'd ask since you might still be on, lol

No they didnt test vitamin shoppe but i know thats good to go because ive seen it work time and time again with people.
They did not test the NOW brand

 

[DOGGCRAPP]

 

[MR. BMJ]

View attachment 114666

I was trying to be more discreet and cryptid, and you went way above, lol!

That's a bunch of shit results, and most of those companies, I've never even heard of. These are like wahack-a-mole companies, they just pop up a dime a dozen to rip people off....they probably change names every few months.

Thanks for all you do as always, DC! Staying with the tried and true is the way to go with Vitamin Shoppe!

Was hoping a quality Amazon company would pop up and make it easy, lol.

 

[Bleed]

Ive never bought any of those. I use jarrow , true nutrition, bulk supplements, qunol, now, nordic naturals, and some others im forgetting.

Hopefully im getting close to what i pay for.

View attachment 114666

 

[NGL34]

Dont waste money your money on otc supplements. The best thing you can do to maintain healthy kidneys is avoid nephrotoxic medications, maintain healthy BP and blood glucose levels and avoid dehydration.

The first treatment in the hospital for kidneys is usually normal saline to flush the kidneys out. Then trying to find the nephrotoxin sunstance or what ever is causing kidney insult and fix it, either through elimation, flushing out or dialysis. No special herbs or medicine is really used.

 

[muscle96ss]

Dont waste money your money on otc supplements. The best thing you can do to maintain healthy kidneys is avoid nephrotoxic medications, maintain healthy BP and blood glucose levels and avoid dehydration.

The first treatment in the hospital for kidneys is usually normal saline to flush the kidneys out. Then trying to find the nephrotoxin sunstance or what ever is causing kidney insult and fix it, either through elimation, flushing out or dialysis. No special herbs or medicine is really used.

That's because most doctors know nothing about supplements and think they are all dangerous. On my initial visit to Mayo Clinic back in early 2017 to get on the kidney transplant list; the doctor told me, "I don't know anything about supplements, but they aren't regulated by the FDA so I think they are all dangerous". And she proceeded to tell me I had to quit taking every supplement I was taking. Every single doctor I encountered in the entire transplant department echoed the same sentiment.

Unfortunately, our medical system is geared towards the pharmaceutical industry and view the supplement industry as all villians.

 

[69cyclerider]

^^^^^ because most doctors and hospitals are in big pharmas pocket