Leptin Human Recombinant

[dece870717]

Why are there no sponsors with Leptin Human Recombinant peptide?

I thought about it and I'm surprised its not available with any places that carry peptides for bodybuilding purposes. Injecting leptin would be one of, if not, the greatest peptide aid for cutting ever!


"The news reports were based on a study published by researchers at New York's Columbia University [1]. The researchers gave leptin injections to lean and obese volunteers who had recently lost weight.

The team, led by Dr. Michael Rosenbaum, found that most of the metabolic and hormonal changes which mean people have a hard time keeping the weight from creeping back on were reversed once leptin levels were restored to pre-weight loss levels.

The study, though interesting, doesn't really tell us much that we didn't know already.

Rosenbaum and his team reported similar results several years ago in a study published in the Journal of Clinical Endocrinology and Metabolism, where a low-dose course of "replacement" leptin reversed some of the metabolic changes that occur during weight loss [2].

In the study, four subjects (2 men and 2 women) were fed 800 calories per day until they'd lost 10% of their initial weight. This led to a drop in both leptin and thyroid hormone concentrations, along with a reduction in the metabolic rate.

For the next five weeks, subjects received low-dose leptin injections twice a day to bring leptin back to pre-diet levels. These "replacement doses" of leptin reversed the drop in energy expenditure and thyroid hormone levels. The participants also continued to lose fat while preserving muscle tissue.

It looks like a drop in leptin production acts as a signal of negative energy balance (you're burning more calories than you're taking in) and low energy reserves, rather than indicating a positive energy balance and increased energy reserves.

What's more, a drop in leptin concentrations seems to have a bigger impact on your body than increasing leptin levels above the normal physiological range.

"The primary functional role of leptin is apparently to defend — not reduce — body fat by increasing food seeking and decreasing energy expenditure when fat stores are insufficient," writes Dr. Rosenbaum in the Journal of Clinical Investigation. "Physiological responses to concentrations of leptin below and above this threshold are very asymmetrical: decreased concentrations of leptin trigger full-strength counterregulation to what is "perceived" as a threat to survival; concentrations of leptin above the threshold — signaling "sufficient" or excess fat stores — are not responded to vigorously, or at all."

In other words , your body will fight harder against losing fat than it will against gaining fat. That's why most people find it a whole lot easier to get fat than they do to get lean.

So, while some have referred to leptin as an "anti-obesity hormone," it's probably more accurate to label it as an "anti-starvation" hormone that tells your brain what to do when energy is in short supply."

Is leptin why the lost weight creeps back on?

So cutting would become way more efficient and there would basically never be any slow down or halt in body fat loss.

 

[bboveri]

I was reading an article on this from Lyle McDonald.

Now, as I pointed out in my last book, injectable leptin is a pipe-dream at this point, an effective dose costing nearly $1000/day (not to mention requiring twice daily injections). Using bromocriptine or other dopamine agonists seemed to fix at least part of the problems by sending a false signal to the brain, making it think leptin levels were normal. Recent studies that have given injectable leptin to dieters show that that fall in leptin is one of the primary signals in initiating the adaptation to dieting. However, unlike in rats, injecting leptin into humans doesn’t fix all of the problems.