im currently on a low dose of .25 mg a day.. and im on my 4th day right now and all i can say is this stuff is slowly working.. i can already see the color changing... as for the sides, i got a bit nauseous on the first shot but have been ok since then(take after a full meal). from what ive been reading many experience darkening of moles and it usually went along with a higher dose, hence the reason im on a .25 mg a day dose, but im sure the amount of sun one gets also had a factor in that. i plan on getting sun on friday and the weather out were i live will be in the mid 60's so ill post and let u know any negatives sides that come up after that session.... but from what ive been told and read, MT2 is one hell of a game changer if administered correctly without over doing it...