Naringin and hematocrit

[tjitsu]

Has anybody used naringin to try and lower theyre hematocrit levels?

I have seen a study about it and some mentions, Mike Arnold mentioned it in an article also.

Have you used it? Did it help? What was your protocal etc.

Thanks

 

[TheRoid]

Been using it for 2 years now, 500mg/day.
I used to need donating blood every 2 months to keep my HCT below 50, now once in 6 months suffices. Works for me.

 

[nothuman]

I looked into it before for the same purpose and chose not to. It inhibits absorption of too many important things and it doesn't seem to benefit for hematocrit much.

 

[tjitsu]

Been using it for 2 years now, 500mg/day.
I used to need donating blood every 2 months to keep my HCT below 50, now once in 6 months suffices. Works for me.

What is your hct now?

 

[tjitsu]

I looked into it before for the same purpose and chose not to. It inhibits absorption of too many important things and it doesn't seem to benefit for hematocrit much.

Inhibits? My understanding is that it does the complete opposite.

 

[nothuman]

Inhibits? My understanding is that it does the complete opposite.

If Stewie happens to see this, he can answer your question but when he told me, I stopped giving it any more thought.

 

[Stewie]

I looked into it before for the same purpose and chose not to. It inhibits absorption of too many important things and it doesn't seem to benefit for hematocrit much.

I've mentioned this several years ago on this particular topic.

Naringin is a weak inhibitor of selective isoenzymes, such as CYP34A/2D9/2D6. There's some interplay between Naringin and P-glycoprotein metabolism. That's a topic in itself. The active component responsible in GFJ (grapefruit juice) is Furanocoumarins/Bergapten. These two are more of a potent inhibitor of CYP3A4, more so than Naringin. That's if we're discussing GFJ.

As for as Narginin effects on lowering one's HH. I wouldn't waste my time, effort or money.