Once inside quickly absorbed. When you receive an empty stomach early peak Cmax can be reached in 15 minutes, but 90% of the average Cmax is achieved within 60 min (from 30 to 120 min). The absolute bioavailability of approximately 15% of. At the recommended dose range (5-20 mg), the value index "area under the curve of the concentration-time? (AUC) and C max increased proportionally to the dose.
Metabolism. Vardenafil is metabolized predominantly liver enzymes with izoformyCYP3A4, as well as CYP3A5 and CYP2C9 cytochrome P450. The average T1 / 2 vardenafil is 4-5 h, and the major metabolite M1 - about 4 hours in the blood contained glucuronide metabolite M1. The concentration of the rest of the metabolite M1 is 26% of the concentration of active substance. Profile of selectivity on phosphodiesterase M1 is similar to those of vardenafil; in vitro the ability to inhibit PDE-5 is 28% compared with vardenafilom, which corresponds to 7% of the effectiveness of the drug.
end there**broken link removed**