IMO if you have supra physiologic Test levels I think it's just fine to have E2 a little higher. On 200mg Test a week, I don't think most people will have any "high estrogen" symptoms at with Estradiol in the 40-50 range. Now if a guys is more of a natural endomorph and more pear shaped with thicker skin, then maybe Estradiol should stay a little lower (20-25ish).
I think for most guys running 300mg Test or higher per week, they won't have any issues with Estradiol 50-60+ since their total Test levels will be 1500 or higher on those dosages. For me personally, I have never been able to dial in a good AI dosage (Arimdex or Aromasin) without tanking my estrogen. So now I stick with Nolvadex to just plug the receptor rather than crash Estradiol.
Also, for me adding a DHT compound like Mast, Primo, or Winny helps keep things in check. I know people debate this but my lab work over the years confirms that is works "for me". (Note: I try to stay away form Primo and Winny except 1x/year because of the negative affect on lipids).