deca gyno

malcom young · Jul 31, 2009

How do you prevent deca induced gyno?

SOCOM · Jul 31, 2009

I've read pramipexole takes care of that

Showy0023 · Jul 31, 2009

SOCOM said:
I've read pramipexole takes care of that

Worked like a champ for me. Prevention wasn't why I was taking it.......I actually got it then got on the pramipexole and it was gone within a few weeks. Learned a valuable lesson.

Macro · Jul 31, 2009

Showy0023 said:
Worked like a champ for me. Prevention wasn't why I was taking it.......I actually got it then got on the pramipexole and it was gone within a few weeks. Learned a valuable lesson.

**broken link removed**

will take credit for introducing prami to the community and for encouraging researchstop to carry it (so that further research can be done on this rather exciting and different d2 receptor agonist)

Newman · Aug 1, 2009

I've read that the L-dopa in mucuna pruriens inhibits prolactin & since deca gyno is prolactin related, mucuna MAY help out with that.

jdchaffin · Aug 1, 2009

Showy0023 said:
Worked like a champ for me. Prevention wasn't why I was taking it.......I actually got it then got on the pramipexole and it was gone within a few weeks. Learned a valuable lesson.

just currious if your willing to share. why where to taking it then?

Showy0023 · Aug 1, 2009

jdchaffin said:
just currious if your willing to share. why where to taking it then?

I was on a 16 week cycle over the winter:

Test e @ 500 mg/e5d
Deca @ 400 mg/e5d

This is the same cycle (same compounds / same dosage) that I have ran 2 times in the past the ONLY difference was the length....instead of capping it off @ 12 weeks I added another month. Towards the end (about 3 weeks left) I got some hard painful lumps behind my nipples. Within a few days some of the lumps got to be the size of peas. I was already on a anti-e that I know worked and after some research I decided it was prolactin related. Got some parmi (over nighted!!!!) and started @ .25mg/ed for week....then I bumped it to .5 mg/ed for the rest of the cycle and ran it for about another month after I was done.

Within the first week the lumps stopped growing and they became virtually painless.......it took about another month to 6 weeks before they actually went away, this is when I discontinued the parmi.

The reason I said I wasn't using it for prevention was because I never had this type of issue in the past so I never incorporated parmi in my cycle. I think I got lucky that all my gyno went away. I fully plan on running this same cycle again this winter and I WILL be using .25 mg of parmi ED!!!!!! Lesson learned!

Macro · Aug 1, 2009

prolactin issues may be present from the beginning, or they may present at any time. have heard SO MANY TIMES -- "never had an issue with (blank) before". there are two primary reasons for this... one the effects were subtle and until the most recent experience they had not crested to become problematic and the other main reason is that repeated exposure caused an endocrine shift, usually with respect to overflow damage from elevated dopamine, dopeg and dopal metabolites, wherein the excess dopamine has shifted in favor of increased prolactin release as opposed to mediated prolactin and GH release.

all androgens stimulate dopamine release and DAT, eventually this can become an issue (or it can be an issue right off) because dopamine excess means more neurotoxic metabolites particularly in tissues associated with stimulating GH and prolactin release.

Pramipexole not only abrogates this, but over time it can restore dopaminergic neurons (by essentially removing the offenders and by its limited- yet pretty much only beneficial d2 like receptor stimulus).

King-kong · Aug 2, 2009

Prami also worked for me. Took it for Tren not deca. I thank Macro for this and wish I knew many years ago. Never realized some compounds cause Prolactin related Gyno.
I wonder if NPP has the same side issues?

iprimate · Aug 2, 2009

Newman said:
I've read that the L-dopa in mucuna pruriens inhibits prolactin & since deca gyno is prolactin related, mucuna MAY help out with that.

L-dopa is a precursor of the neurotransmitter dopamine. Dopamine inhibits prolactin secretion when it binds to the dopamine D2 receptors on the surface of the pituatary lactotroph cells[1]. Dopamine is the natural ligand of these dopamine D2 receptors. Pramipexole is an agonist of the dopamine D2 receptors. So yes, you are correct in your inference, Mucuna pruriens (Velvet Bean) will inhibit prolactin secretion.

Macro · Aug 2, 2009

iprimate said:
L-dopa is a precursor of the neurotransmitter dopamine. Dopamine inhibits prolactin secretion when it binds to the dopamine D2 receptors on the surface of the pituatary lactotroph cells[1]. Dopamine is the natural ligand of these dopamine D2 receptors. Pramipexole is an agonist of the dopamine D2 receptors. So yes, you are correct in your inference, Mucuna pruriens (Velvet Bean) will inhibit prolactin secretion.

at first... then actually it will raise it... for the very reasons cited above... dopamine metabolites are neurotoxic.. taking l-dopa is not a solution.. it CAN be ok short term, for some people... generally reccomend against it. in some ways its a bit like throwing gasoline on the fire (when you are talking dopamiergic damage)

if you do take l-dopa or drugs that support dopamine release or DAT then HIGHLY reccomend stacking selegiline or other mao-b inhibitor.

MrCyp · Aug 2, 2009

Dont waste your time on liquid cabergoline. Either use pharm grade cabasar or liquid prami.

Newman · Aug 2, 2009

Macro said:
at first... then actually it will raise it...

Do you have any handy references on that?

I know a prominent board member here who has been using Mucuna for a long while & hasn't suffered any ill effects.

Macro · Aug 3, 2009

Newman said:
Do you have any handy references on that?

I know a prominent board member here who has been using Mucuna for a long while & hasn't suffered any ill effects.

thats a bit like saying that people who use AAS and elevate dopamine and norepinephrine for a long while and dont suffer ill effects (until of course, they do). by adding levodopa, he is just throwing gasoline on the fire so to speak. use of selegiline or rasagiline will offset a lot of that, though its also important to maintain glutathionone levels (to prevent crosslinking).

Macro · Aug 3, 2009

these are some sides of l-dopa, unlikely to be caused directly at the low to moderate doses that most people use, but in combination with the excess dopamine and NE from AAS possible...

More serious are the effects of chronic levodopa administration, which include:

End-of-dose deterioration of function
On/off oscillations
Freezing during movement
Dose failure (drug resistance)
Dyskinesia at peak dose
Recent studies have demonstrated that use of L-DOPA without simultaneously giving proper levels of serotonin percursors depletes serotonin
The long term use of L-DOPA in PD has been linked to the so called dopamine dysregulation syndrome.[3]

kevin2590 · Jun 8, 2012

Gyno Symptoms

Hi guys, I am 34 and just stared my first cycle 3 weeks ago. I take 250 deca and 250 testogel every week for 10 weeks. I just stared feeling the sensitiveness in my nipples and my right side kind of felt sore today so it freaked me out a little bit. I have nolva in hand and just ordered liquidex and letro, they should be here in couple of days. My question is am i taking the right dose of deca and test? Is it normal to feel sensitive in the early stage of cycle? If it is the initiation of gyno, which route to take? Is it ok to take nolva during cycle or just take A.i or letro during and keep the nolva for pct? Am i too late for A.i or letro? I guess i m prone to gyno

Please help!!!...Thanks...

Swifto · Jun 9, 2012

kevin2590 said:
Hi guys, I am 34 and just stared my first cycle 3 weeks ago. I take 250 deca and 250 testogel every week for 10 weeks. I just stared feeling the sensitiveness in my nipples and my right side kind of felt sore today so it freaked me out a little bit. I have nolva in hand and just ordered liquidex and letro, they should be here in couple of days. My question is am i taking the right dose of deca and test? Is it normal to feel sensitive in the early stage of cycle? If it is the initiation of gyno, which route to take? Is it ok to take nolva during cycle or just take A.i or letro during and keep the nolva for pct? Am i too late for A.i or letro? I guess i m prone to gyno Please help!!!...Thanks...

Old thread...

Always use an AI, this can help control prolactin if it increases.

I'd start Tamox 20mg/ED right now and then run an AI to control E when you get it. I prefer Aromasin 10mg/ED and then usually keep a dopamine agonist on hand just incase prolactin levels rise, but they usually dont - but keep one on hand IMO.