I recently did an ancestry dna test and uploaded the raw DNA data to promethease.com to compare my genes to all known diseases and risk factors.
promethease is a wikipedia style database containing pretty much all of the latest DNA knowledge.
This really helps one get a look into their health and what you have to be cautious about.
There are literally thousands of conditions/risk factors that are provided with the results, the gene sequence studies used to obtain the risk ration are provided and here are some of my most concerning:
3.5-4.4x risk of thrombosis See discussion at Rs6025. Odds ratio based on 2013 and 2017 studies.
7x risk of male baldness 7x risk of baldness among men, according to.
In Japanese, 6.2x increased risk of developing prostate cancer, a 3x increased risk of developing BPH, and a 5.5x increased risk of developing metastatic prostate cancer
>3x risk of schizophrenia
I do have some positives
Longer lifespan, 0.28x lower risk of dementia, 0.31x lower risk of Alzheimer's.
some bodybuilding related stuff
Mix of muscle types. Likely sprinter. Normal for white people. One working and one defective copy of the gene for alpha-actinin-3 in fast-twitch muscle fibres. This genotype may indicate somewhat impaired muscles, however many sprinters and some endurance athletes have this.
Some more of the fun stuff to know and appear to be true based on my life experience:
More stimulated by coffee You appear to have a common genotype in the gene CYP1A2 which Drug Metabolism coffee more slowly than some other forms. The same amount of caffeine will tend to have more stimulating effect on slow metabolizers than on fast metabolizers. Ciprofloxacin is also metabolized by CYP1A2, but is unclear if your genotype should influence its effect.
Sweeth tooth tendency; slightly higher odds of preferring candy see rs838133 for discussion
Can taste bitter. Normal tasting ability for bitterness. This makes turnip, cabbage, brussels sprouts, broccoli, and other cruciferous vegetables taste more interesting and less horribly bland. Coffee and dark beers also tastes more bitter. You can taste propylthiouracil (PROP), PTC, and related chemicals. On the other hand, you can't taste the unpleasant bitterness of the tropical fruit from the Bignay tree, it will taste sweet to you. You probably eat healthier.
Here is a link to a dynamic sample report, very cool stuff especially when you know its about your genes:
https://files.snpedia.com/reports/promethease_data/genome_Lilly_Mendel_v4_ui2.html
promethease is a wikipedia style database containing pretty much all of the latest DNA knowledge.
This really helps one get a look into their health and what you have to be cautious about.
There are literally thousands of conditions/risk factors that are provided with the results, the gene sequence studies used to obtain the risk ration are provided and here are some of my most concerning:
3.5-4.4x risk of thrombosis See discussion at Rs6025. Odds ratio based on 2013 and 2017 studies.
7x risk of male baldness 7x risk of baldness among men, according to.
In Japanese, 6.2x increased risk of developing prostate cancer, a 3x increased risk of developing BPH, and a 5.5x increased risk of developing metastatic prostate cancer
>3x risk of schizophrenia
I do have some positives
Longer lifespan, 0.28x lower risk of dementia, 0.31x lower risk of Alzheimer's.
some bodybuilding related stuff
Mix of muscle types. Likely sprinter. Normal for white people. One working and one defective copy of the gene for alpha-actinin-3 in fast-twitch muscle fibres. This genotype may indicate somewhat impaired muscles, however many sprinters and some endurance athletes have this.
Some more of the fun stuff to know and appear to be true based on my life experience:
More stimulated by coffee You appear to have a common genotype in the gene CYP1A2 which Drug Metabolism coffee more slowly than some other forms. The same amount of caffeine will tend to have more stimulating effect on slow metabolizers than on fast metabolizers. Ciprofloxacin is also metabolized by CYP1A2, but is unclear if your genotype should influence its effect.
Sweeth tooth tendency; slightly higher odds of preferring candy see rs838133 for discussion
Can taste bitter. Normal tasting ability for bitterness. This makes turnip, cabbage, brussels sprouts, broccoli, and other cruciferous vegetables taste more interesting and less horribly bland. Coffee and dark beers also tastes more bitter. You can taste propylthiouracil (PROP), PTC, and related chemicals. On the other hand, you can't taste the unpleasant bitterness of the tropical fruit from the Bignay tree, it will taste sweet to you. You probably eat healthier.
Here is a link to a dynamic sample report, very cool stuff especially when you know its about your genes:
https://files.snpedia.com/reports/promethease_data/genome_Lilly_Mendel_v4_ui2.html