- Joined
- Dec 21, 2007
- Messages
- 279
Its been a while since I've used DNP, and was just reviewing the latest to refresh my memory and came across several studies showing micro doses having beneficial effects for health when it came to cognitive function, decreased triglycerides, neuroprotective qualities, etc. Anyway, I was just curious to know if anyone has run small doses for extended periods of time here. I saw a post in my web search by someone posting about extended use, and thought it was interesting. It is below, let me know what you think...
"No personal input, but I remember a thread on a different forum of someone who took low-dose DNP for 4 years straight and claimed some mitochondrial-related benefits:
"No personal input, but I remember a thread on a different forum of someone who took low-dose DNP for 4 years straight and claimed some mitochondrial-related benefits:
I have been on a low-dose of DNP for nearly 4 years and figured some of you may be interested in hearing about my experience.
Most consistently, I used a low dose, 250 mgs, every other day. I experimented with doses up to but no more than 500 msg everyday. The results have been life-changing. I truly believe DNP to be one of the best supplements available for metabolic health and life-extending purposes. Over the four years I have never been sick with the exception of contracting mononucleosis about 2 years ago. I used to be very susceptible to sickness and infections. My energy levels and sense of well-being are high, my hormone levels are all in healthy ranges, my body composition is excellent and more resilient to bad diets and lack of exercise, and I even believe I sleep better. Metabolism remains at an elevated state, even upon cessation. I believe it is helping to maintain mitochondrial health and perhaps could help reverse age-related mitochondrial decline. It reduces ROS and has improved my insulin sensitivity and glucose tolerance. I have suffered no known negative side-effects and do not use supplements to mitigate its side effects, nor do I believe it to be necessary. I do not necessarily believe DNP to be solely responsible for my excellent state of health, but do believe it has helped maintained a healthy metabolic environment, which as a result has improved my general health and well-being.
My concerns: I plan to continue DNP supplementation perhaps for the extent of my life. I have reviewed libraries worth of literature on the subject and have found little reason to discontinue, but if you believe there are significant concerns that should be addressed I would be delighted to hear your insight. My primary concern is cataracts. At the doses I take I have not noticed a yellowing of any tissue or bodily fluids. At higher doses, though, I did experience yellowing of bodily fluids. I'm concerned about the possibility that DNP may deposit yellow pigments into the lens of the eye, facilitating the cataract development that is sometimes reported. At this point, and with the doses I use, I hope this does not become a problem. Annual eye appointments have not suggested it to be a problem as of yet, but never-the-less it is a concern of mine.
Second, I wonder the impact of DNP on gut microbiota. I would assume that DNP-mediated mitochondrial uncoupling would occur in the gut bacteria as well. I don't know if this would promote healthy bacterial colonization or reduce it. I have not noticed any significant gut-related problems but I still plan to have a stool analysis performed some day. Although, it may not be too revealing as I have had a strong medical history with antibiotic use, up until about 4 years ago."