The abstract of the first article supports both fasting and calorie restriction. Time and time again you make very confident claims but you fail to back them up. What are your credentials to make you so confident in your strongly stated absolutes? Since you must have read the entire article you should post up the quantitative experimental results that show some insignificant difference between fasting and calorie restrictiuon on marker of autophagy, toxin elimination since you claim there is no advantage of autophagy over calorie restriction.
Ageing Res Rev. 2018 Nov;47:183-197.
doi: 10.1016/j.arr.2018.08.004. Epub 2018 Aug 30.
The effect of fasting or calorie restriction on autophagy induction: A review of the literature
Mohammad Bagherniya 1 ,
Alexandra E Butler 2 ,
George E Barreto 3 ,
Amirhossein Sahebkar 4
Affiliations
Abstract
Autophagy is a lysosomal degradation process and protective housekeeping mechanism to eliminate damaged organelles, long-lived misfolded proteins and invading pathogens. Autophagy functions to recycle building blocks and energy for cellular renovation and homeostasis, allowing cells to adapt to stress. Modulation of autophagy is a potential therapeutic target for a diverse range of diseases, including metabolic conditions, neurodegenerative diseases, cancers and infectious diseases. Traditionally, food deprivation and calorie restriction (CR) have been considered to slow aging and increase longevity. Since autophagy inhibition attenuates the anti-aging effects of CR, it has been proposed that autophagy plays a substantive role in CR-mediated longevity. Among several stress stimuli inducers of autophagy, fasting and CR are the most potent non-genetic autophagy stimulators, and lack the undesirable side effects associated with alternative interventions. Despite the importance of autophagy, the evidence connecting fasting or CR with autophagy promotion has not previously been reviewed.
Therefore, our objective was to weigh the evidence relating the effect of CR or fasting on autophagy promotion. We conclude that both fasting and CR have a role in the upregulation of autophagy, the evidence overwhelmingly suggesting that autophagy is induced in a wide variety of tissues and organs in response to food deprivation.