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ACTION OUTSIDE THE RECEPTOR

MikeS

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Hey maybe the main response from AS is from the interaction with the Androgen receptor. However therre are several other ways AS can work outside of the receptor. I know one may be neurological response from things like DHT. Another is increase in red blood cell count. Is this correct? What are the other actions? This came up in a discussion with a knowledgable gym bro. I hate when I dont have all the answers! :eek: :D
 

xcelbeyond

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What about the ability of certain gear, like tren and test, to substantially increase IGF-1?

xcel
 

BALDNAZI

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Your forgeting...............

the placebo effect.The power of the mind.The #1 main reason they are so effective(besides the obvious physical effect)is just the thought that you are a raging lunatic filled with the sweet nectar we call JUICE.Works for me and I'm sure it has the same effect on you guys.Good thread,interesting to see what are some other ways the gear hits us.........
 

DIEZEL666

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I know that they have proved that a higher dosage of Test Enanthate activates satellite cells.
 

MikeS

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Xcel-good,-I forgot that one.
 

raybravo

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something big cat from bodybuilding.com wrote , very informative :
"Testosterone commences by increasing calcium influx in the SR in muscles. Since calcium release is required for the cross-bridging of myofibrils this increases contractile potential in the muscle. Muscle contraction leads to two things : release of arachidonic acid from intramuscular fat and the upregulation of GLUT4 independent of insulin. Since both are increased by testosterone, these have just been facilitated.

At the same time creatine flow is improved. Creatine improves multiplication through division of sattelite cells in muscle. Testosterone converts to estradiol which increases again the ability of GLUT4, but then dependent of insulin. It also increases outflow of GH, which stimulates release of IGF-1 in the muscle. IGF-1 then makes the sattelite cells donate nuclei to the damaged muscle tissue. This creates more androgen receptors per fiber, so as to speed recovery. More AR however also means increased growth potential and more room for testosterone to exert its actions on protein synthesis. Testosterone binds to the AR and would normally have a relative loose binding, but since arachidonic acid when free is turned into prostaglandins like PGF2a, these will in turn stabilize the binding, increasing and prolonging the genetic transcription. Testosterone expresses similar fashions of genetic transcription as all steroids, safe for winstrol, which appears to be unique. But in several testosteron's transcription was nominally higher.
Story doesn't even end there. Testosterone antagonizes the cortisol receptor, again leading to a positive nitrogen balance and less muscle breakdown. It converts to DHT, which increases neural response, strength and uptake of nutrients in muscle. And it upgrades beta adrenoreceptors again leading to increased second messenger protein synthesis and a greater release of fatty acids from adipose tissue that can be used as fuel. Lastly because of the massive increases in both insulin dependent and independent GLUT4 it allows for massive influx and overcompensation of glucose, amino acids for transcription and creatine. So first of all providing the building blocks for anabolism and secondly due to increased glycogen and creatine in the muscle, cell volume increases. And cell volume is again a direct signal for increased protein synthesis. “
 

MikeS

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JOHN-

Part of the fun of it for most of us. Hey you can get pretty detailed with stuff like cars/bikes, wheather, politics and have a great level of intellegence in those areas that pretty impressive.
Different strokes! :D
 

mike man

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water retention

Can help quite a bit (thru estro conversion and others) in the fact that it cusions joints and can also help keep the muscles fuller therefore creating a better recovery environment.
Although the many bad sides that accompany water retention; bloat, adema of feet and/or hands, high BP, having to buy new pants that fit comfortably, and a just plain bad look most of the time, it does has some positive effects if you look at it from a scientific standpoint.
 

Winston

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Steroids cause you to hold more nitrogen than you release, giving you a positive nitrogen balance. Increases red blood cells and is anti-catabolic :)

Gotta love em :)

Winston
 

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