Not at all. I was bouncing between posts.
http://www.professionalmuscle.com/forums/articles-forum/6990-good-read-about-tendons-5.html
I linked several studies there that oppose the view that test decreases collegen. I'm my ADD mind I mixed topic with this one.
HeavyIron has a old thread on another forum with some good info as well. It talked about 2mg/lb body weight for helping injuries.
I'm looking at it from the idea of enhanced health rather than strictly gains. Something along the line of long term dosages for the TRT patient for a optimal combo of replacement and enhancement.
I've also found ones that oppose the rat study on deca.
Collagen synthesis in postmenopausal women during... [Metabolism. 1990] - PubMed - NCBI
Serum PIIINP was measured every 3 months during the study. Anabolic steroid therapy resulted in a more than 50% increase (P less than .001) in serum PIIINP at 3 months, which thereafter decayed but remained significantly increased throughout the study period. Serum PIIINP showed the same pattern during estrogen-progestogen therapy, but to a lesser degree. We conclude that anabolic steroids stimulate type III collagen synthesis in postmenopausal women, while estrogen-progestogen therapy may have such an effect, but only to a lesser degree.
ScienceDirect.com - Archives of Medical Research - Higher Physiological Doses of Nandrolone Decanoate Do Not Influence the Bezold-Jarish Reflex Control of Bradycardia
We concluded that 4 weeks ND treatment induced an anabolic effect and the beginnings of LV remodeling, mainly due to excessive collagen deposition in the cardiac extracellular matrix. However, the treatment did not influence BJR control of bradycardia, an effect that could be explained by an enhanced efferent vagal tonus in DECA animals.
Nandrolone Decanoate and Load Increase Remodeling and Strength in Human Supraspinatus Bioartificial Tendons
Ioannis K. Triantafillopoulos, MD*,, Albert J. Banes, PhD,,, Karl F. Bowman, Jr||, Melissa Maloney, MS¶, William E. Garrett, Jr, MD, PhD# and Spero G. Karas, MD*,,**
From * the Shoulder and Elbow Service, University of North Carolina, Chapel Hill, North Carolina, Department of Orthopaedics, University of North Carolina, Chapel Hill, North Carolina, Flexcell International Corporation, Hillsborough, North Carolina, the Department of Biomedical Engineering, the || School of Medicine, University of North Carolina, Chapel Hill, North Carolina, ¶ Flexcell International Corporation, Hillsborough, North Carolina, and the # Department of Orthopaedics, Duke University, Durham, North Carolina
** Address correspondence to Spero G. Karas, MD, Chief, Shoulder and Elbow Service, University of North Carolina, Department of Orthopaedics, CB#7055, Chapel Hill, NC 27599-7055 (e-mail:
[email protected] ).
Background: To date, no studies document the effect of anabolic steroids on rotator cuff tendons.
Study Design: Controlled laboratory study.
Hypothesis: Anabolic steroids enhance remodeling and improve the biomechanical properties of bioartificially engineered human supraspinatus tendons.
Methods: Bioartificial tendons were treated with either nandrolone decanoate (nonload, steroid, n = 18), loading (load, nonsteroid, n = 18), or both (load, steroid, n = 18). A control group received no treatment (nonload, nonsteroid [NLNS], n = 18). Bioartificial tendons’ remodeling was assessed by daily scanning, cytoskeletal organization by staining, matrix metalloproteinase–3 levels by ELISA assay, and biomechanical properties by load-to-failure testing.
Results: The load, steroid group showed the greatest remodeling and the best organized actin cytoskeleton. Matrix metallo-proteinase–3 levels in the load, steroid group were greater than those of the nonload, nonsteroid group (P < .05). Ultimate stress and ultimate strain in the load, steroid group were greater than those of the nonload, nonsteroid and nonload, steroid groups (P < .05). The strain energy density in the load, steroid group was greater when compared to other groups (P < .05).
Conclusions: Nandrolone decanoate and load acted synergistically to increase matrix remodeling and biomechanical properties of bioartificial tendons. Clinical Relevance: Data suggest anabolic steroids may enhance production of bioartificial tendons and rotator cuff tendon healing in vitro. More research is necessary before such clinical use is recommended.