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Berberine with metformin

juggy38

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Anybody try running both concurrently?

I was reading on some diabetic forums, that metformin users are seeing improvement when adding berberine, possibly due to different MOAs.
 

suppdude

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I can’t recall but Stewie dropped some knowledge on this topic. Not recommended.


Sent from my iPhone using Tapatalk
 

Stewie

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The delivery of a drug is dependent on several different types of enzymes and or transport proteins. In the particulars you're asking, berberine inhibits two specific transport proteins---OCT1 and OCT2 (organic cation transporter 1 and 2). Given that, metformin is dependent on the proper function of these two organic cation transporters.

Berberine will basically cancel out most, if not all of metformins action.

So, no not a good idea.
 

[email protected]

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i would be happy to be able to run one of this without
flooding the toilet with diarrhea..
any remedy for this issue?
 

aDw32

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but what about using berberine during a day , lets say with 1st and 4th meal and and then metformine before bed considering using lots of gh
 

MyNameIsJeff

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i would be happy to be able to run one of this without
flooding the toilet with diarrhea..
any remedy for this issue?
1) Take it with meals
2) Titrate the dose slowly. Start with 250mg for first 2 weeks, then go to 500.
3) Have healthy gut microbiome. Lots of threads here on gut health, prebiotics, fiber, glutamine, etc.

That being said, some 20% of people just cannot tolerate Metformin even with the above approach.
 

juggy38

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The delivery of a drug is dependent on several different types of enzymes and or transport proteins. In the particulars you're asking, berberine inhibits two specific transport proteins---OCT1 and OCT2 (organic cation transporter 1 and 2). Given that, metformin is dependent on the proper function of these two organic cation transporters.

Berberine will basically cancel out most, if not all of metformins action.

So, no not a good idea.

Nice. Thanks Stewie
 

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