In one big a's threads he mentions one of the only reasons to come off would be if your receptors become saturated. Ive heard mixed ideas about weather long cycles upgrade or downgrade receptor sensitivity.. So I guess cleaning out would mean giving your body a break from supra levels of test and increasing your body's receptiveness for when you go back on? I dunno that could all be bullshit, just want to get opinions on it
Not exactly true... SHBG is significantly increased about 8-10 weeks into a cycle I remember reading this in a study. This study is also backed up by bro logic as 8-12 weeks has been the standard cycle time for quite a while as most guys quit gaining around that time frame. Although I think the same study said that after 20 or so weeks SHBG began to come back down.
Androgen Receptors are renewed over and over again on a daily basis based on their half-life so you cannot 'clean them' as the ones that are there and have not yet formed a hormone/receptor complex are already new and fresh.