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- Feb 26, 2016
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For those asking about dutasteride or those saying they can't use finasteride even at low dosages; Dutasteride at a dosage of 0.5 mg twice per week will generally lower DHT by 70%, the same as 5 mg finasteride. In fact, it may be better since finasteride has a spread of 50-90% DHT reduction depending on the individual whereas dutasteride is more consistent at lowering DHT.
The studies also show a slight advantage in hair regrowth from 0.5 mg dutasteride x 2 per week versus 5 mg finasteride daily.
Anecdotally, MANY patients who could not touch finasteride even at low doses have no side effects from dutasteride or only very mild ones. (slight libido reduction, slight brain fog). Often resolving with time on their own.
(https://pubmed.ncbi.nlm.nih.gov/15363566/ " Onset of new drug-related adverse events were reported most frequently at the start of therapy and declined over time in patients receiving dutasteride.")
I will add that Finasteride has one effect that dutasteride does not that may be the reason side effects can be severe for some on finasteride but not on dutasteride. Finasteride inhibits an enzyme called PEMT. This enzyme is responsible for converting noradrenaline into adrenaline and also for producing choline. Both noradrenaline and choline can effect mood and cognition. (Anti-depressants like wellbutrin can increase/affect noradrenaline and anti-alzheimers drugs increase choline or acetylcholine effects in the body).
Another thing i will add is that as we get older, BPH/prostate growth can become a real problem, especially for men using AAS and HGH. This decreases quality of life and recovery as you wake up multiple times during the night to urinate. A 5-alpha reductase inhibitor can still shrink the prostate even on high doses of AAS/testosterone as DHT is the main driver of this growth/swelling effect, as always, prevention is the BEST medicine there is.
Here is an experienced hair loss doctor from Spain discussing his experience with low dose dutasteride (0.5 mg twice per week) in his patients who could not handle finasteride:
Here's a before and after of 0.5 mg x 2 per week *No Minoxidil* :
And another (This guy started on daily, switched to x 2 per week at 6 months then x 1 per week at 9 months; confounded with minoxidil use)
Finasteride vs Dutasteride DHT % drop and recovery time:
Hair improvement differences between dutasteride and finasteride and at different dosages:
Table showing efficacy of dutasteride 2-7 times per week. Stable means hair loss stopped. + means improvement ++ means significant improvement:
Dutasteride 0.5 mg x 3 per week w/ oral minoxidil - 6 months :
Dutasteride x 3 times per week at 0.5 mg - 2 years:
The studies also show a slight advantage in hair regrowth from 0.5 mg dutasteride x 2 per week versus 5 mg finasteride daily.
Anecdotally, MANY patients who could not touch finasteride even at low doses have no side effects from dutasteride or only very mild ones. (slight libido reduction, slight brain fog). Often resolving with time on their own.
(https://pubmed.ncbi.nlm.nih.gov/15363566/ " Onset of new drug-related adverse events were reported most frequently at the start of therapy and declined over time in patients receiving dutasteride.")
I will add that Finasteride has one effect that dutasteride does not that may be the reason side effects can be severe for some on finasteride but not on dutasteride. Finasteride inhibits an enzyme called PEMT. This enzyme is responsible for converting noradrenaline into adrenaline and also for producing choline. Both noradrenaline and choline can effect mood and cognition. (Anti-depressants like wellbutrin can increase/affect noradrenaline and anti-alzheimers drugs increase choline or acetylcholine effects in the body).
Another thing i will add is that as we get older, BPH/prostate growth can become a real problem, especially for men using AAS and HGH. This decreases quality of life and recovery as you wake up multiple times during the night to urinate. A 5-alpha reductase inhibitor can still shrink the prostate even on high doses of AAS/testosterone as DHT is the main driver of this growth/swelling effect, as always, prevention is the BEST medicine there is.
Here is an experienced hair loss doctor from Spain discussing his experience with low dose dutasteride (0.5 mg twice per week) in his patients who could not handle finasteride:
Here's a before and after of 0.5 mg x 2 per week *No Minoxidil* :

And another (This guy started on daily, switched to x 2 per week at 6 months then x 1 per week at 9 months; confounded with minoxidil use)

Finasteride vs Dutasteride DHT % drop and recovery time:

Hair improvement differences between dutasteride and finasteride and at different dosages:

Table showing efficacy of dutasteride 2-7 times per week. Stable means hair loss stopped. + means improvement ++ means significant improvement:

Dutasteride 0.5 mg x 3 per week w/ oral minoxidil - 6 months :

Dutasteride x 3 times per week at 0.5 mg - 2 years:
