get more for your money....

[Jrflex10er]

When you take an oral dietary supplement or even a medication, it travels from your mouth through your esophagus to your stomach, where the true digestion and metabolism processes starts. From your stomach, the ingredients enter your small intestine and eventually will be absorbed for entrance into your bloodstream. We all know that some are excreted via either the fecal or urinary route, but the question exists: is there a better way to deliver more of a product to the body? The answer is yes and this answer is important because not all vitamins, minerals, herbals, other supplements or medications are well absorbed. A pharmaceutical company from California has came up with a way to help absorption of these supplements. The active agent is polyethylene oxide, which is already used in ice cream, toothpaste, and other products that need fluffing. This allows a substance with this in it to say in the stomach for up to 12 hours allowing for better absorption. And we all know its not how much you take its how much you absorb. So I'm kind of curious about this when it hits the stores in the near future.

 

[Extra_Strong]

bump

 

[HELLA SWOLE]

interesting....

 

[Snarf]

Oral bioavailability is a complex issue and is not determined by any one factor for a given substance.

For example each of the following can have an affect on bioavailability:
- stomach ph
- gut motility
- food affect
- upper Gi versus lower GI absorption
- bile activity
- first pass hepatic metabolism
- cytochrome P450 metabolic pathway activity

Then pharmacokinetc issues come into play like the specific half life of the drug, clearance rates, P450 induction, active metabolite or pro-drug considerations, etc.

Also, remember that low bioavailability for most substances occurs becuase it has TOO MUCH gut exposure and becomes denatured through natural digestions. Keeping it in your gut for 12 hours would probably mean less gets to your bloodstream.

I am not familiar with the substance you mentioned, but how can it keep something in your stomach for 12 hours? Does it keep it in the upper GI or lower GI. THink about how much food you eat in that time period - this would cause serious constipation or GI blockage (potentially fatal) if it really did that.

If they feed you some bullshit that it only keeps the "good chemicals/supplement/vitamins" in your GI for that long, then I would love to see how that works.

Since most basic supplements are pretty cheap, if you are worried about bioavailability just take an extra dose if that makes you feel better.

What specific products are they claiming that this will help with?

 

[zephyr22]

Very good post snarf....

Yes, if this substance was to truly keep a supplement immobile in the gut for 12 hours it would certainly cause a ileus(clogged up intestine with no motility). Then good old surgery to remove the portion of intestine is the extreme case with a good old colostomy bag. Also many tablets have MCC micro crystaline cellulose which helps the tablet dissolve quickly etc... this is what many medicine need to have happen otherwise your pooping out the actuall drug in tablet form. Increased exipeints (sub that makes tabs dissolve quickly) in the mix will actually increases absorbtion of certain medicines. In most cases this is good unless it is a controlled release medicine in which the press them harder and give different layers of coatings, waxes etc.... The 12 hour idea Most people would think wow this a great idea. However you and I snarf both know this wont help jack. If it was really this great it would have been in processing tablets years and years ago.

 

[ag-guys]

interesting...:st:r-wars

AG
www.ag-guys.com

 

[dr. livingstone]

This is the same supplement industry that sells their products as "time released", a bogus concept as the supplement can only be aborbed in the intestines and this limited time of absorbtion stays unchanged by making a product "time released".

 

[Jrflex10er]

The pill they were talking about in the article I was reading was mostly multi-v's snarf. Snarf why would they try to do this when a gel cap is just as good as anything for absorbing? If pills are so hard to absorb then why are most bodybuilders massive anyways? I think it's hype.....

 

[leapfrog]

absortion of compounds

cytochrome P450 metabolic pathway activity

grapefruit juice lowers this and allows more absortion of compounds.this was discovered because alot of older people were overdosing on some of their meds because of this,so now some meds have a warning labels "do not take with grapefruit juice".look in jama if you don't believe me.

leap