I am using HGH EOD now. Don't overcomplicate things. Rotate between ED and EOD dosing and see which you prefer.
Regarding the OP I am the same and get bad fatigue and when I dose a bit higher I can sometimes experience terrible joint pain. When I dose EOD I find I am most tired the day after dosing (pre bed) and it drops off. I am actually enjoying it this time round because the dreams I get from higher doses pre bed are incredible

I only have the crazy dreams the days I dose it pre bed. This time round the joint pain started the day after my 1st dose but the fatigue is ok as my body has adapted after using it on/off over the last few years. I have tried it most ways because of the bad side effects I have experienced over the years with HGH and it will never be perfect but I do prefer EOD larger dosing. As posted for fatloss frequent dosing is superior but I prefer higher EOD dosing for muscle gain and for the reasons I mentioned above.