they all can in theory, and ive seen many claim that via many compounds, for me it was LSD. Remember like alan watts said about psychedelics "once you get the message , hang up the phone" and robert anton wilson added "anything more is transcendental masterbation". It take time to fully understand and comprehended and implement the realizations given to us via the revelations and epiphanies we experience during these times. I enjoyed changa which is like ayuhuasca more than blasting off on DMT. DMT I always met bizarre and malovelent entities and it was taxing on my nervous system. changa is way more fun and manageable, ive tried and done them all, including novel ones, o-pce, 3meopcp, FXE, MXE, all psychedelics and potent, 4acodmt etc , DOM,DOB, A-PVP, A-PiHP, 2-CB, MESCALINE HCL , MDA
ego death is not the goal, ask dr carl jung or aldus huxley etc. ego dissolution is the key
check out dr john lilly "metaprogramming the human biocomputer" he wrote it after a heroic dose of K
doors of perception from aldus huxley was also written after heroic mescaline dose