If you so kind explain that for me, i'll be greatefull .Okay, that was a bit harsh. But that was a lot of hubris in your first post for someone who doesn't understand the concept of carbs being protein sparing.
wrongAre you serious? You obviously you do gain more muscle eating BARELY enough protein for a bodybuilder (300g protein per day), then like a small bikini girl (180g protein per day). If somone thinks 180g protein for a everage size bodybuilder is sufficient, then he clearly don't know what he's doing...
wrong
Carbohydrate spares muscle protein breakdown, mostly mediated by insulin. But also by providing energy substrates for glycolysis and sparing (and repleting) glycogen stores.If you so kind explain that for me, i'll be greatefull .
Yea that well known fact, but in terms of "building", "sparing" seems to not be the same thing. Thats may not be proven by science but for many of bodybuilder anegdotal data, higher protein (300g +) seems equale more muscle and i never gonna believe that evarage size bodybuilder could succesfuly (mean optimaly/maximizing resoult) eat 180g or less then 300g protein a day.Carbohydrate spares muscle protein breakdown, mostly mediated by insulin. But also by providing energy substrates for glycolysis and sparing (and repleting) glycogen stores.
This can be estimated fairly easily from published literature. From this paper full saturation in the model system used is ~20 nM. https://www.jbc.org/article/S0021-9258(17)33103-4/pdf. Now estimate the volume of the BBer which is close to their weight in kg. kg is roughly equal to L if we neglect density for convenience. Do the simple math and you have your concentration in moles needed for full saturation. 2 micro mol (2 x 10^-6 mol) of Testosterone is needed to fully saturate a 100 kg BBer if he is similar to the system used in the study. Probably this can be expected to be within a factor of 2 to 4. Testosterone is 288 gram/mol. Doing the math gives 57 mg circulating in the body at any given time. It is well known that mid range normal levels give near full saturation. Mid normal is 6 micromol/L; 6 x 10^6 mol/L x 100 L = 60 x 10 ^3 mol x 288 g/mol = 0.17 grams = 170 mg. Both estimates are within a factor of 3.How do you "know" that androgen receptor saturation is achieved at 3.5g??
Has androgen receptor saturation actually ever been studied or proven on humans??
Sorry I made a decimal error. Not enough morning coffee. Corrected above.This can be estimated fairly easily from published literature. From this paper full saturation in the model system used is ~20 nM. https://www.jbc.org/article/S0021-9258(17)33103-4/pdf. Now estimate the volume of the BBer which is close to their weight in kg. kg is roughly equal to L if we neglect density for convenience. Do the simple math and you have your concentration in moles needed for full saturation. 2 micro mol (2 x 10^-6 mol) of Testosterone is needed to fully saturate a 100 kg BBer if he is similar to the system used in the study. Probably this can be expected to be within a factor of 2 to 4. Testosterone is 288 gram/mol. Doing the math gives 0.57 mg circulating in the body at any given time. It is well known that mid range normal levels give near full saturation. Mid normal is 6 micromol/L; 6 x 10^9 mol/L x 100 L = 60 x 10 ^6 mol x 288 g/mol = 0.00017 grams = 0.170 mg. Both estimates are within a factor of ~3.
So, based on published works and calculated two different ways ~1.10 mg of circulating testosterone will saturate the androgen receptor in a 100 lb BBer. In most people this will be reached with 100 - 150 mg/w of test cypionate.
Now let's say that while in cycle at 8 weeks the androgen receptors double. That would mean that roughly 300 mg/w would saturate the receptors. Certainly we see more improvement past 300 mg/w so there is more going on than what can be estimated at the AR. BUT!! we are ALL certainly saturated at the AR at 3.5 g/w.
If androgen receptors are saturated at 150mg of test cyp for a 100kg (225lb) bodybuilder, then how do you gain more size from a gram of test when all androgen receptors are already saturated ?So, based on published works and calculated two different ways ~110 mg of circulating testosterone will saturate the androgen receptor in a 100 lb BBer. In most people this will be reached with 100 - 150 mg/w of test cypionate.
Now let's say that while in cycle at 8 weeks the androgen receptors double. That would mean that roughly 300 mg/w would saturate the receptors. Certainly we see more improvement past 300 mg/w so there is more going on than what can be estimated at the AR. BUT!! we are ALL certainly saturated at the AR at 3.5 g/w.
You need therapy not scientific research if you're taking 3.5g gear let alone 6. I guarantee the guys on here taking that much gear aren't pros, just in a really fucked up place.Let's say a guy was on a 6g cycle, given that he didn't feel sick and it didn't mess his digestion up, no estrogen or prolactin problems etc... He would see better results than taking 3.5g of gear, how is that possible when we know that androgen receptors are saturated at 3.5 grams, so theoretically anything more would be a waste right?
I know, taking that much gear is foolish, I'm just askingYou need therapy not scientific research if you're taking 3.5g gear let alone 6. I guarantee the guys on here taking that much gear aren't pros, just in a really fucked up place.
This is a really really stupid comment. You need plenty more context than this blanket statementi think it's the same concept and you aren't going to gain more muscle eating 300g protein per day
as you would with 180g of protein per day..
There must be other mechanisms outside of cytosolic and nuclear AR activation and/or activation levels vary with recruitment of ancillary factors etc.If androgen receptors are saturated at 150mg of test cyp for a 100kg (225lb) bodybuilder, then how do you gain more size from a gram of test when all androgen receptors are already saturated ?
For a friend right?I know, taking that much gear is foolish, I'm just asking