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Interesting Article RE: Trenbelone Enanthate for HRT

Massive G

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Found this interesting over @ MESO-RX

The use of the anabolic steroid trenbolone has a long history in the bodybuilding but it has never really been considered a steroid suitable for therapeutic use in medicine. The U.S. Food and Drug Administration has not approved tren for use in humans. The media has often demonized it as a dangerous veterinarian steroid never intended for human use. However, the perception of trenbolone may soon change with the publication of a favorable study in a major scientific journal.


Joshua Yarrow and his colleagues at the University of Florida feel that trenbolone may be a viable alternative to testosterone for androgen replacement therapy. They are set to publish their study results in the February 2011 issue of the American Journal of Physiology – Endocrinology and Metabolism.

The researchers report that trenbolone enanthate may have certain advantages over testosterone that may make it an appealing treatment option for some individuals. Bodybuilders may be familiar with many of these findings.

Trenbolone is not adversely affected by the aromatase or 5-alpha reductase enzymes that metabolize testosterone into estradiol and dihydrotestosterone, respectively. Bodybuilders have enjoyed tren for years precisely because they are able to avoid steroid side effects related to estrogen and DHT.

Yarrow reports that low-dose trenbolone enanthate effectively produces anabolic effects in muscle size and partially maintains bone mineral density without causing prostate enlargement or polycythemia in castrated laboratory rats.

Supraphysiological dosages of testosterone enanthate were required to produce anabolic effects similar to low-dose trenbolone administration. However, negative side effects of prostate enlargement and elevated hemoglobin became problematic at this dose of testosterone.

Selective androgen receptor modulators (SARMs) may be the current darlings of scientific research into alternative options for androgen replacement therapy, but University of Florida researchers are excited by the “SARM-like potential” of trenbolone.

They suggest that the actions of trenbolone are similar to selective androgen receptor modulators (SARMs). Low-dose trenbolone is called “SARM-like” because of the positive anabolic effects in muscle and bone without negative side androgenic side effects of prostate enlargement or polycythemia.

Trenbolone may have benefits over testosterone in terms of androgen receptor activation, the upregulation of growth factors such as IGF-1 and fibroblast growth factor, and anticatabolic mechanisms.

Competitive bodybuilders have often preferred using trenbolone in the weeks prior to a bodybuilding competition due to its purported effects at accelerating fat loss.

The current study confirmed that trenbolone has more potent lipolytic effects on visceral adipose tissue than testosterone milligram per milligram. Furthermore, visceral fat loss increased in a dose-dependent manner with trenbolone. In other words, the more tren used, the greater the fat loss.

Trenbolone’s lack of aromatization, while generally desirable, has often been problematic for bodybuilders who have used trenbolone as the only steroid in a cycle. Therefore, most bodybuilders include an aromatizable steroid such as testosterone or Dianabol in their trenbolone steroid stacks.

Researchers also recognize that the lack of aromatization could be a potential problem if trenbolone is used alone in androgen replacement therapy. In their study, trenbolone only provided a partial bone protective effect when administered to castrated rats. The authors attribute this to the non-aromatizable nature of trenbolone.

They conclude that low-dose trenbolone enanthate treatment has SARM-like effects on muscle/fat body composition. Androgen replacement therapy with low-dose trenbolone could potentially produce anabolic gains comparable to supraphysiological testosterone treatment without the associated side effects. The therapeutic risk-benefit profile of low-dose trenbolone appears superior to supraphysiological testosterone treatment; however, additional research into this treatment option is necessary.

The researchers should be applauded for dispassionately and objectively researching the potential of trenbolone in androgen replacement therapy. Trenbolone is an anabolic steroid that has been demonized more than others due to its limited use (in pellet implants used by veterinarians to increase muscle growth in livestock). Fortunately, they looked past the political stigma associated with trenbolone to revisit a therapeutic use for an old steroid.

Special thanks to Michael Scally, M.D. for his diligence in staying on top of anabolic steroid medical research and sharing this study with MESO-Rx.

Yarrow JF et. al. 7{beta}-hydroxyestra-4,9,11-trien-3-one (Trenbolone) Exhibits Tissue Selective Anabolic Activity: Effects on Muscle, Bone, Adiposity, Hemoglobin, and Prostate. Am J Physiol Endocrinol Metab. 2011 Jan 25. [Epub ahead of print]



Read more from this MESO-Rx article at: Trenbolone for Androgen Replacement Therapy | MESO-Rx Steroid Blog
 

Massive G

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I still would advise one to add in 50 -100 mg a week of Testosterone Enanthate or Cypionate to the 100 mg Trenbelone Enanthate to keep the drive up and other related positive effects from testosterone.

The question I have is the effect on lipids, liver and kidney enzymes over time.

The article pointed out reduced stress on the prostrate and hematocrit levels and estrogen, but there people still can have an issue with progesterone.
 

dragonfire101

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Interesting...I think they are missing some true aspects of real HRT and why testosterone is used.

Such as people with true hypogonadism have low libido. How will Tren address and increase low libido. It usually has an opposite effect.

If Tren acts like a SARM why not use SARM. If I was a researcher I would be looking at using SARMS in HRT.
 

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dragonfire101

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I still would advise one to add in 50 -100 mg a week of Testosterone Enanthate or Cypionate to the 100 mg Trenbelone Enanthate to keep the drive up and other related positive effects from testosterone.

The question I have is the effect on lipids, liver and kidney enzymes over time.

The article pointed out reduced stress on the prostrate and hematocrit levels and estrogen, but there people still can have an issue with progesterone.
19 Nors like Tren increases progesterone like you said and increased progesterone stimulates prolactin and elevated prolactin, can worsen HPTA.
 

JonnyO

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Tren A and E increase my libido WAY more than test does, no comparison for me and I have zero progesterone sides.
 

Massive G

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Tren A and E increase my libido WAY more than test does, no comparison for me and I have zero progesterone sides.
I was gonna note that as well JO, many people report increased libido on anabolics.....but still think as dragonfire mentioned a small bit of test is needed for normal physiological processes in the body.
The most common problems in injectable testosterone based HRT are hematocrit, prostate and estrogen that's why many endos want the patch pellet or gel.
 

dragonfire101

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I was gonna note that as well JO, many people report increased libido on anabolics.....but still think as dragonfire mentioned a small bit of test is needed for normal physiological processes in the body.
The most common problems in injectable testosterone based HRT are hematocrit, prostate and estrogen that's why many endos want the patch pellet or gel.
I notice increased libido on anabolics first couple weeks. I just ran and tested Boladrol and noticed that. After several weeks though my libido is crap. I'm assuming since HPTA gets shut down eventually with the anabolics. With test though even if the Test shuts down HPTA I still have a libido afterward.

The most common problems in injectable testosterone based HRT are hematocrit, prostate and estrogen that's why many endos want the patch pellet or gel.
From my understanding and speaking with my endo Bioidentical hormone replacement therapy (BHRT) is what they want. I guess bioidentical hormone therapy is suppose to be a more natural hormone therapy,because the gels and troche etc. are hormones that are more identical, on a molecular level, when compounded compared to synthesized testosterone injectables.

So BHRT based testosterone therapy like you noted is suppose to reduce negative sides related to hematocrit, prostate and estrogen.
 

MR. BMJ

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I think the main thing to keep in mind with this RAT study is that it only raises concern, until HUMAN studies are (hopefully) performed. I read this a few weeks ago, and thought it was an interesting read.

Though, if it takes a rat study to get the ball rolling on human studies, then it's done it's purpose, imo.

I'm all for further research on Trenbolone, my mouth is salivating, as it is my favorite AAS.....well, my nips disagree with that though:(

From purported anecdotal reports, most users complain of dramatic HDL drops, which i agree is a concern as well. I'd have to go back and see how it affected their HcT levels though. I never had mine checked on Tren.

I've had my HCT checked from a CBC test many times as I work in health clinics, and it always came back normal when on even high amounts of AAS, so I may not be the best candidate to go off of...thankfully. Even on Anadrol, It was only ever at the high end of normal.

That being said, I think this all changes, at different ages for everybody, especially once you hit mid-30's and for sure 40's. I am 35 in a month....so most (okay all) of those tests I had were below the range I stated here above:)

I've only ever used Tren Acetate though too. Not sure i'll be able to take it again though because it irritates my damn nips:banghead:

I've had an increase in sex drive with tren, but i've never taken it by itself. I have always used at least 'some' test with it, as for the reasons mentioned by MG, as test is involved and responsible for dozens/hundreds of mechanisms in the body. By itself, i'd never chance that....this seems to be a hit or miss experience with users in regards to an increase in sex drive. Personally, I think it is only do to an increase in androgenicity....much like the "dbol bridging" between cycles.....(meaning it doesn't increase test in the body, but as an androgen with androgenic properties, will increase sex drive....FOR SOME).

Hopefully this will relate to more research in the future, where we can use human subjects.


BMJ
 
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jay_dub

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Interesting...I think they are missing some true aspects of real HRT and why testosterone is used.

Such as people with true hypogonadism have low libido. How will Tren address and increase low libido. It usually has an opposite effect.

If Tren acts like a SARM why not use SARM. If I was a researcher I would be looking at using SARMS in HRT.
I'm the exact opposite, tren makes my libido sky rocket beyond belief. More than anything I've ever tried.
 

dragonfire101

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2x remember tren is an androgen not an anabolic!
This is true.. I really should be saying androgen's when referring to certain 19 nors, but I think everyone is just assuming anabolic is everything, but test when this is not true, but just loose terminology everyone was using in thread to describe something other that test. That stuff can get complicated though. I believe Test has a 1/1 ratio of being anabolic/androgenic? I know there is a list someone that shows, which drug are more anabolic vs androgenic. So if tren is more of an androgen there would be greater impact negative on prostate? Anyways Tren is suppose to be very anabolic as well. So thats why that stuff gets confusing.

Anabolics are suppose increase protein metabolisms or muscle building effects more and lower the androgenic effects thus why they were created.


Any ways anabolic-androgenic steroids (AAS) are derivatives of testosterone, which is naturally occurring so I will stick with my Test.
 
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Ehren

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I still would advise one to add in 50 -100 mg a week of Testosterone Enanthate or Cypionate to the 100 mg Trenbelone Enanthate to keep the drive up and other related positive effects from testosterone.

The question I have is the effect on lipids, liver and kidney enzymes over time.

The article pointed out reduced stress on the prostrate and hematocrit levels and estrogen, but there people still can have an issue with progesterone.
Interesting stuff, MG. I read, on here actually, that the more androgenic the compound, the more it raises HCT. Do you see any truth to that? Or is it BroScience?

This study makes me wonder why they aren't using something like Masteron, an androgen that seems to be less notorious than Tren without Progesterone sides. Prostate problems with Mast perhaps?
 

thatbloke

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well i cruise on 200mg test cyp and 60mg tren eth a week, so this is great info for me
 

ennui

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Tren A and E increase my libido WAY more than test does, no comparison for me and I have zero progesterone sides.
This is what I've heard from a lot of people too. I haven't personally ran tren (at least, not yet), but I have heard that many people see a drastic increase in libido on tren ace or enenthate, even when running it with no test at all. I've also noticed that you don't read about "fina dick" nearly as much as you do "deca dick".
 

10brandonr

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well i cruise on 200mg test cyp and 60mg tren eth a week, so this is great info for me
Cool! just curious, how does that treat you, as opposed to just test. Hows your blood work come in? I'd love to hear how long you've been doing it for and what you notice from. I'm interested in doing something similar.
 

karl lazlo

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Tren increases my libido as well, and yes, I have run it by itself...I've also NEVER run it with Test, and I've never had any problems. I always thought this was because of its high androgenic component.
 

Steve123

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Tren A and E increase my libido WAY more than test does, no comparison for me and I have zero progesterone sides.
It increases libido but can do some funny things around ED. I've had times when I just can't finish.. Go and go and go.. like a porn star but it takes forever. Not sure I would want Tren only.

This is true.. I really should be saying androgen's when referring to certain 19 nors, but I think everyone is just assuming anabolic is everything, but test when this is not true, but just loose terminology everyone was using in thread to describe something other that test. That stuff can get complicated though. I believe Test has a 1/1 ratio of being anabolic/androgenic? I know there is a list someone that shows, which drug are more anabolic vs androgenic. So if tren is more of an androgen there would be greater impact negative on prostate? Anyways Tren is suppose to be very anabolic as well. So thats why that stuff gets confusing.

Anabolics are suppose increase protein metabolisms or muscle building effects more and lower the androgenic effects thus why they were created.

Any ways anabolic-androgenic steroids (AAS) are derivatives of testosterone, which is naturally occurring so I will stick with my Test.
Yeah, Testosterone is the bench mark with a ratio of 1:1. Tren is supposed to be around 500x more Anabolic than Test. Also much more Androgenic. It will be an interesting study but unfortunately, it would be unethical to study it on Humans. Therefore, what we're left with is hard scientific data, directly related to humans, for close to 70 years with Testosterone; not much more than conjecture around Tren..
 

hemipower

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I love tren but not the sides, and have posted this a few times...it doesn't take NEARLY as much as most would have you believe, to have GOOD effects from tren. If testosterone is 100/100 anabolic/androgenic ratio and tren is 5x this (500/500) then WHY take 400-800mg?! That would be similar to (but not the same I know) as taking 2-4g of test!!

I recently found some left over tren A and decided to TRY it at 1/4mL 3 days a week added to 250mg a week TRT and LOVED it...thats only 75 mg tren! I am wanting to do 100mg weekly total tren E (split into 2 shots) and intend to try it in addition to 250mg TRT for several months and see if I can remain side effect free as I did on 75mg tren A for those 5 weeks. I used to do 300mg tren a week and had indigestion, anxiety, night sweats, etc etc and looked great but felt TERRIBLE.

I look forward to seeing positive effect without those negatives soon with 1/3 the dose. Now the positive effect won't be as large either...but without the sides if I can get 30% of the results and not notice the sides or have NONE I will be happy with that result for sure. And go through WAY less of it! :rolleyes:
 
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