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Letrozole and erection problems

phoenix2

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Ho guys, i'm cruising with 150 mg of test weekly and 50 mg of proviron daily.
I'm very gyno prone since i already have it from puberty and i'm very sensitive to estrogens.
At a point i started to have nipple sensitivity, so i started to take letro, firstly at 2.5 mg a day, then after a week i dropped to 0.625 mg. Nipple sensitivity is gone, but the problem is that i started to experience erection problems. When i am with my girlfriend libido is good, but erections are soft and i lose them very quickly, and hardly gain them back. Morning wood instead is so strong that wakes me up every day, i wish i had that strong erections during sex. Cialis and Viagra don't help, maybe Viagra a little bit.
For the rest i feel good and i look very dry and vascular, altought a little flat.
Non the question is: is letro the culprit of soft erections and loss of erections?
I've always tought that low estrogens can cause libido loss but no erections problems.
How should i move now?
I have also pharma aromasin on hands.
 

Black Beard

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Ho guys, i'm cruising with 150 mg of test weekly and 50 mg of proviron daily.
I'm very gyno prone since i already have it from puberty and i'm very sensitive to estrogens.
At a point i started to have nipple sensitivity, so i started to take letro, firstly at 2.5 mg a day, then after a week i dropped to 0.625 mg. Nipple sensitivity is gone, but the problem is that i started to experience erection problems. When i am with my girlfriend libido is good, but erections are soft and i lose them very quickly, and hardly gain them back. Morning wood instead is so strong that wakes me up every day, i wish i had that strong erections during sex. Cialis and Viagra don't help, maybe Viagra a little bit.
For the rest i feel good and i look very dry and vascular, altought a little flat.
Non the question is: is letro the culprit of soft erections and loss of erections?
I've always tought that low estrogens can cause libido loss but no erections problems.
How should i move now?
I have also pharma aromasin on hands.
You cooked your E2. Letrozole is too strong to take at 2.5 mg daily. This will not reverse gyno and will make you feel terrible.

1.If you have gyno: Get some nolvadex or raloxifene. Run them for 12 weeks at 20 mg nolva or 60 mg ralox daily. This will reverse gyno 90% of the time. It works but you have to be consistent and patient. Gyno starts as a small pea size lump that can be tender when pressure is applied and eventually grows into a bigger lump and then a disc shaped lump that can appear like a cone shape sometimes from certain angles.

Low estradiol will definitely cause low libido and erection problems in a lot of people. You likely have undetectable levels of estradiol. You now have to wait for the letrozole to get out of your system and for your body to start making E2 again.

Next time, if you feel high E2 symptoms, start with 0.5 mg arimidex per week or 25 mg aromasin per week for starters. Letrozole can be used as an AI but it's very strong and sometimes causes sides even without completely lowering E2. (Theory is that it's a potent AI in the brain more so than the others)

Crashing E2 can make you dryer/vascular and flat. That's why some guys run AI for competition.
 
Last edited:

danieltx

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You cooked your E2. Letrozole is too strong to take at 2.5 mg daily. This will not reverse gyno and will make you feel terrible
Black Beard - how do you explain his strong morning erections? My understanding is that nocturnal / morning erections are a good general indicator of healthy hormone balance.
 

Black Beard

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Black Beard - how do you explain his strong morning erections? My understanding is that nocturnal / morning erections are a good general indicator of healthy hormone balance.
Erections are a complex event. The endocrine system is only one small part of the arousal/erection process. Dopamine/prolactin, nitric oxide/vasodilation, etc.


There are a lot of guys with perfect testosterone/E2 and garbage erections.
 

Ashop

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Erections are a complex event. The endocrine system is only one small part of the arousal/erection process. Dopamine/prolactin, nitric oxide/vasodilation, etc.


There are a lot of guys with perfect testosterone/E2 and garbage erections.
It truly can be a very complicated situation in some cases. So many factors to consider its just not cut and dry.
 

Black Beard

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It truly can be a very complicated situation in some cases. So many factors to consider its just not cut and dry.
For sure, then there's the mental aspect. Anxiety/stress from work/life or performance anxiety. (These things affect the physical aspect as well by increasing vasoconstriction/sympathetic CNS response)
 

bad rad

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FWIW, Letro crushed my E2 @ .625 weekly while one 600mg Test.
 

Fa Seeshus

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Raloxifene is awesome, and works just fine on TRT doses

ED is just one of the many problems of AI overuse. I mentioned this before at length, but my bones started leaching calcium because of too much exemestane... Not to mention crashing my HDL.
 

phoenix2

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So what i can do now?
Should i stop letro cold turkey?
On a side note, a weird thing. When i was taking 2.5 mg ed my libido was higher, mood was better... but i looked watery.
It seems that reducing the dose has bringed all the low e2 sides... like bad mood, low libido and joint pain/clicking. And i'm much more dry now with the lower dose. Very strange...
 

Black Beard

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So what i can do now?
Should i stop letro cold turkey?
On a side note, a weird thing. When i was taking 2.5 mg ed my libido was higher, mood was better... but i looked watery.
It seems that reducing the dose has bringed all the low e2 sides... like bad mood, low libido and joint pain/clicking. And i'm much more dry now with the lower dose. Very strange...

Hell yes, stop letrozole immediately. It's going to hang around for a little bit.


You are probably dryer with a smaller dose because many effects of medications/hormone changes are delayed due to a phenomenon called gene expression. So the low E2 effects are just adding up now. This explains why you felt more watery on 2.5 mg, because the low E2 hadn't kicked in fully yet. It only takes one tab of 2.5 mg letrozole to knock your E2 to very low/undetectable levels within 24 hours depending on your baseline E2.


The reason testosterone takes weeks to see effects is not because of the build up to max serum levels, you are close to max serum levels after 2-3 injections already or immediately if it's a short ester.


The delay happens because it takes time for all the genes to be switched on and produced. These are called "genomic effects". You see it with things like testosterone/thyroid hormone that take time to "kick in".


Things like coffee that you feel immediately have "non-genomic effects", in coffee/caffeine's case adenosine receptor antagonism.


Do you actually have gyno or just started getting tender/itchy nipples? This will dictate our next approach.
 
Last edited:

phoenix2

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Hell yes, stop letrozole immediately. It's going to hang around for a little bit.


You are probably dryer with a smaller dose because many effects of medications/hormone changes are delayed due to a phenomenon called gene expression. So the low E2 effects are just adding up now. This explains why you felt more watery on 2.5 mg, because the low E2 hadn't kicked in fully yet. It only takes one tab of 2.5 mg letrozole to knock your E2 to very low/undetectable levels within 24 hours depending on your baseline E2.


The reason testosterone takes weeks to see effects is not because of the build up to max serum levels, you are close to max serum levels after 2-3 injections already or immediately if it's a short ester.


The delay happens because it takes time for all the genes to be switched on and produced. These are called "genomic effects". You see it with things like testosterone/thyroid hormone that take time to "kick in".


Things like coffee that you feel immediately have "non-genomic effects", in coffee/caffeine's case adenosine receptor antagonism.


Do you actually have gyno or just started getting tender/itchy nipples? This will dictate our next approach.
Yes i know the difference between genomic and non genomic effects. It takes time for the latter due to genes expression, translation into protein production and so on...
Steroids hormone have non genomic effecs too... But this is not the point...
It's a weird reaction that i have to AIs... exemestane does that too..
If i take too much AI i look watery... probably is just because it flattens me out so much that skin is less stretched... or there is some mineral imbalance that leads to more cortisol and aldosterone production.. who knows..

For the gyno.. i've it since puberty.. and at the moment i have slightly puffy nipple.. and they are more sensitive to stimulus like cold... they seems to leave a mark on the t shirt, but if i squeeze them nothing comes out...
Oh and they often acts like it's cold..
I'm also taking 2.5 mg ed of bromocriptine (which i tolerate well)...
 

Black Beard

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Yes i know the difference between genomic and non genomic effects. It takes time for the latter due to genes expression, translation into protein production and so on...
Steroids hormone have non genomic effecs too... But this is not the point...
It's a weird reaction that i have to AIs... exemestane does that too..
If i take too much AI i look watery... probably is just because it flattens me out so much that skin is less stretched... or there is some mineral imbalance that leads to more cortisol and aldosterone production.. who knows..

For the gyno.. i've it since puberty.. and at the moment i have slightly puffy nipple.. and they are more sensitive to stimulus like cold... they seems to leave a mark on the t shirt, but if i squeeze them nothing comes out...
Oh and they often acts like it's cold..
I'm also taking 2.5 mg ed of bromocriptine (which i tolerate well)...
That's cool, 99% of the human population does not know about gene expression.

You are correct that being flat can make you look watery as well.

Regardless, you have no reason to be taking letrozole; especially at that dosage.

I would drop letro cold turkey today, start ralox or nolvadex now and run it 12 weeks. 2 weeks from now, add aromasin 12.5 mg x 2 per week to control E2 if you are staying on 150 mg test E. That should do the trick but you may need a little more or a little less. You can't test E2 while taking ralox/nolva as it can artificially increase E2 and can have cross-reactivity with the test and pop as E2.

LC/MS assay shouldn't have cross-reactivity but SERMs can sometimes increase E2 levels, so i wouldn't want any variables interfering with the test.
 
Last edited:

phoenix2

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That's cool, 99% of the human population does not know about gene expression.

You are correct that being flat can make you look watery as well.

Regardless, you have no reason to be taking letrozole; especially at that dosage.

I would drop letro cold turkey today, start ralox or nolvadex now and run it 12 weeks. 2 weeks from now, add aromasin 12.5 mg x 2 per week to control E2 if you are staying on 150 mg test E. That should do the trick but you may need a little more or a little less. You can't test E2 while taking ralox/nolva as it can artificially increase E2 and can have cross-reactivity with the test and pop as E2.

LC/MS assay shouldn't have cross-reactivity but SERMs can sometimes increase E2 levels, so i wouldn't want any variables interfering with the test.
Unfortunately, i've already tried ralox (pharma evista) in the past, when i had the same problems with test, up to 120 mg ed for two months and it did absolutely nothing. The only thing that stopped nipples problems was quitting the test. Even with crashed e2 (proven by bloodwork).
Now i don't care too much about nipples, i just want my libido and erections back in full force.
 

johnjuanb1

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Ho guys, i'm cruising with 150 mg of test weekly and 50 mg of proviron daily.
I'm very gyno prone since i already have it from puberty and i'm very sensitive to estrogens.
At a point i started to have nipple sensitivity, so i started to take letro, firstly at 2.5 mg a day, then after a week i dropped to 0.625 mg. Nipple sensitivity is gone, but the problem is that i started to experience erection problems. When i am with my girlfriend libido is good, but erections are soft and i lose them very quickly, and hardly gain them back. Morning wood instead is so strong that wakes me up every day, i wish i had that strong erections during sex. Cialis and Viagra don't help, maybe Viagra a little bit.
For the rest i feel good and i look very dry and vascular, altought a little flat.
Non the question is: is letro the culprit of soft erections and loss of erections?
I've always tought that low estrogens can cause libido loss but no erections problems.
How should i move now?
I have also pharma aromasin on hands.
It's her fault. Time to trade the old clunker in for a 2019 model.
Kidding 🤣

It’ll take time to get your estrogen back up where it needs to be.
Ask her to show up early morning until then. 👍
 

Black Beard

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Unfortunately, i've already tried ralox (pharma evista) in the past, when i had the same problems with test, up to 120 mg ed for two months and it did absolutely nothing. The only thing that stopped nipples problems was quitting the test. Even with crashed e2 (proven by bloodwork).
Now i don't care too much about nipples, i just want my libido and erections back in full force.
Is it noticeable to the naked eye? and how lean are you approximately? Sometimes its mostly estrogenic fatty deposits which SERMs won't do anything for.
 

phoenix2

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Ok. Something is going wrong.
Right now i feel nipple sensitivity. I've tried to squeeze them and a semi-transparent liquid has come out.
Wtf is happening?
Unfortunately at the moment i can't do bloodwork...
Since i feel low e2 i will try to increase bromocriptine to 5 mg ed
 

johnjuanb1

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Ok. Something is going wrong.
Right now i feel nipple sensitivity. I've tried to squeeze them and a semi-transparent liquid has come out.
Wtf is happening?
Unfortunately at the moment i can't do bloodwork...
Since i feel low e2 i will try to increase bromocriptine to 5 mg ed
Sounds like high prolactin killing your dick and causing the leaking nipples.
Hopefully the bromocriptine increase helps.
 

bad rad

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FWIW, I feel best with E2 in the 40ish range. Not everyone needs super low E2 and my libido, erections, and joints feel better a little higher. I also retain more water but quality of life is better.
 

phoenix2

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Sounds like high prolactin killing your dick and causing the leaking nipples.
Hopefully the bromocriptine increase helps.
Ok... but how the fu** is possible on only 150 of test and 50 mg of proviron?
 

Crazy_jay

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Ok... but how the fu** is possible on only 150 of test and 50 mg of proviron?
Because it's most likely not. I've had similar issues as you. After my first cycle, my nipples were puffy and sore, so I ran an anti gyno protocol. Didnt help at all, had bloodwork done, estrogen tanked, test level tanked, prolactin mid range. I can squeeze my nipples right now and get fluid out of them, lots of guys can, the key, dont squeeze them.

Eventually my nipple sensitivity went away. I just recently quit taking an ai and my estrogen got up to 97 and I still had zero nipple issues. I also used to break out on my back really bad but dont seem to anymore. Think it just takes the body some time to adjust.

Also, best gyno protocol and only proven protocol, nolvadex.

Sent from my SM-G965U using Tapatalk
 

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