You will probably hear many different answers on this one. I will tell you that Femara (letrozole) is very powerful and inhibits estrogen very effectively. Always keep in mind that the idea is to keep estrogen in check... not remove it altogether which femara can indeed do. Femara works much better on the cellular level than say Arimidex. IMHO 2.5mg's ingested twice a week will do the trick unless you are one of those chaps that likes to do 1500mg's of test a week along with 50+ mg's of dbol ED. Then the dosage would of course be bumped up. Some say that femara can be "front loaded" as consistent blood levels can take upwards of 60 days to achieve. There may be some creedence to this theory as the New England Journal of Medicine does substantiate this. I, however, would not mess with that tactic. Besides, it usually takes about 2-3 weeks before I see the moon face and by that time there will be enough femara kicking around in my blood to combat it.
If you start to inhibit estrogen to the extent that serum levels drop well below baseline you run the risk of severe irritibility, depression and possibly worst of all... diminished effects/results from your hormone cycle.
Three times a week @ 2.5mg's is about where I would call a high end schedule for this compound.
Hope this helps brotha...
Ursus~