Mechanism of hepatoxicity?

[JCain]

Why are certain oral steroids more toxic than others? Say I take 10mg of oxandrolone vs. 10mg methyltestosterone vs. 10mg stanozolol, they don't have the same toxic effect on the liver even though they are all C-17 methylated. Is it just the structure of the molecule itself that makes it harder/easier to demethylate it? From my background in organic chemistry the difference in hepatoxicity wouldn't seem to have the magnitude that it does due to this. Anyone have more insight?

 

[KillerStack]

Why are certain oral steroids more toxic than others? Say I take 10mg of oxandrolone vs. 10mg methyltestosterone vs. 10mg stanozolol, they don't have the same toxic effect on the liver even though they are all C-17 methylated. Is it just the structure of the molecule itself that makes it harder/easier to demethylate it? From my background in organic chemistry the difference in hepatoxicity wouldn't seem to have the magnitude that it does due to this. Anyone have more insight?

Don't know for sure but type this into google and read the article: "A Closer Look at Steroid Liver Toxicity, Part 1 by M. Fischer". I thought his theory was interesting.

 

[JCain]

Good article

Thanks. This was insightful.