Metformin, keto, and gluconeogenesis

[juicin]

I have been on keto for years. Always kept me tight.

I hear many on this form mention how metformin inhibits gluconeogenesis.

Maybe I don’t fully understand gluconeogenesis but what I understand is it is as the process of which amino acids AND fatty acids are released into the bloodstream. With this said, and if this is actually the correct definition of gluconeogenesis, would then, metformin be a bad option on keto? With keto we want to burn those FFA.

Under the same assumption, then would it be an even worse idea to take metformin before fasted cardio, as so called FFA would not be available to be burned for fuel?

I personally have loved metformin to help stay lean, but wonder if my fasted cardio sessions are being waisted taking metformin immediately before them.

 

[aHarness]

Where you’re pulling the energy from in this context is irrelevant. Yes, you are going to use fat for energy more on a ketogenic diet but you’re also consuming more. It’s just net energy balance that will determine your progress at the end of the day.

As for how much metformin inhibits glucogenesis, I would imagine it’s not that significant otherwise people using it (and it’s a very popular medication) would be running into hypoglycemia issues very quickly which we often don’t see.

 

[juicin]

Where you’re pulling the energy from in this context is irrelevant. Yes, you are going to use fat for energy more on a ketogenic diet but you’re also consuming more. It’s just net energy balance that will determine your progress at the end of the day.

As for how much metformin inhibits glucogenesis, I would imagine it’s not that significant otherwise people using it (and it’s a very popular medication) would be running into hypoglycemia issues very quickly which we often don’t see.

I’m 200lb at 5’7” about 6% right now. I’m trying to get that last bit off. So I use that term keto loosely. Im at about 1500 calories at this point, with the majority coming from protein.

So right now every little thing matters. I know I’m getting into the nitty-gritty of metformin and gluconegenis.

Would you not recommend taking metformin before fasted cardio (very low intensity, 1 hr)?

 

[vwnesta]

Juicin, great question. I’m doing the 500ER metformin, 100 mcg T4, and
2 iu GH on fasted 1 hr cardio. Was recently considering drop Metformin. I’m 7 weeks out from the North Americans. 5’6lbs, 185lb lean. Trying to drop last but like you. Mens physique.

 

[juicin]

Juicin, great question. I’m doing the 500ER metformin, 100 mcg T4, and
2 iu GH on fasted 1 hr cardio. Was recently considering drop Metformin. I’m 7 weeks out from the North Americans. 5’6lbs, 185lb lean. Trying to drop last but like you. Mens physique.

GH before fasted cardio does wonders for me. Specifically because it releases FFA. Sounds like we are in the same boat. I love GH, but once I get really lean the intra-muscular water i hold just hides all my striations. I just switched to gh-frag before fasted cardio and it seems like the water is coming off.

I’ve heard gh-frag stops working after a while and your body gets used to it. Don’t know how true that is, because I love this stuff.

 

[aHarness]

Would you not recommend taking metformin before fasted cardio (very low intensity, 1 hr)?

I don’t think it matters either way for your goal.

 

[gib68sg]

GH before fasted cardio does wonders for me. Specifically because it releases FFA. Sounds like we are in the same boat. I love GH, but once I get really lean the intra-muscular water i hold just hides all my striations. I just switched to gh-frag before fasted cardio and it seems like the water is coming off.

I’ve heard gh-frag stops working after a while and your body gets used to it. Don’t know how true that is, because I love this stuff.

How are you running the frag?

 

[juicin]

How are you running the frag?

200 mcg 1.5 hrs before fasted cardio.
I also take 100-200mcg if I wake up in the middle of the night.

I basically only try to use it in my most-fasted state.

 

[gib68sg]

200 mcg 1.5 hrs before fasted cardio.
I also take 100-200mcg if I wake up in the middle of the night.

I basically only try to use it in my most-fasted state.

Awesome thanks I’m giving it a shot took advantage of some holiday sales