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New Study: Former anabolic steroid users display greater myonuclei density

bbxtreme

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Not that anyone here needs anymore reasons to use more gear, but thought this recent study was interesting:

Higher Myonuclei Density in Muscle Fibers Persists Among Former Users of Anabolic Androgenic Steroids


In summary-

Former anabolic steroid users display greater myonuclei density (i.e., nuclei in skeletal muscle cells) years after reported use suggesting a long-term enhanced anabolic capacity as compared to non-users.
 
I’m curious if dosage played any factor for current and formers mono density but shit man I’ll take it as a win for our team!
 
Here is the full text.

Near the end there are some figures and tables that show the demographics of the previous users, and what they used if you'd like to see.

I can usually get the full text of most things if guys are looking for other stuff too

@Samson250, I tagged you because I meant to reply to you but fucked it up
 

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"The main finding of the present study was that former AAS users demonstrated smaller myonuclei 3 domains, i.e., higher myonuclei density and DNA-to-cytoplasm ratio in type II myofibers compared 4 with controls with no prior AAS use despite a mean duration of four years since AAS discontinuation 5 in former users. These findings suggest an increased transcriptional capacity for myofibrillar 6 biogenesis, which would theoretically translate to an increased retraining capacity"
Since former AAS users are generally smaller than the AAS version of themselves, I wounder if a natural that is the same % LBM lighter than their peak form as the previous AAS user, would display the same myonuclei density...
 
Sooooo….what the hell does all this nerd shit mean?
I summarized it pretty well I thought.

Those who use gear maintain more muscle cells than those who don’t when they come off or don’t exercise to the same degree.

My thoughts on this are also that this could demonstrate why many more seasoned guys don’t have to use nearly as much gear as they did in their earlier years. Thats my theory… could be off base.
 
Sooooo….what the hell does all this nerd shit mean?

ELI5: Drugs cause a permanent change to musculature even years after cessation. That guy will have an easier time building and rebuilding lost muscle than a natty even years later. The effect appears to be more pronounced the more and longer drugs were used.
 
Is this due to sarcoplasmic hypertrophy? I know there is some debate on it. Some say it's nothing lift for myofibrilliar only...then people like Milos think the pump/metabolic work is beneficial
 
My thoughts on this are also that this could demonstrate why many more seasoned guys don’t have to use nearly as much gear as they did in their earlier years. Thats my theory… could be off base.
bingo. still big but the strength does not follow. then add in GH and you have to take even less. 200mg test, 200mg primo. same size as when I was full blast but again strength is long gone at 50 years old.
 
100 percent beleive it. Took a year off once and benched 225lbs for 10 reps first day back. Also have taken months off before and it comes back extremely fast and it's easier now to stay over 200lbs lean natty then. It was in my early 20s
 

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