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New STUDY hints at new ways to fight aging

Jerkyboy

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By Maggie Fox, Health and Science Editor, 9-20-07


WASHINGTON (Reuters) - Researchers said on Thursday they had found more ways to activate the body's own anti-aging defenses -- perhaps with a pill that could fight multiple diseases at once.

Their study, published in the journal Cell, helps explain why animals fed very low-calorie diets live longer, but it also offers new ways to try to replicate the effects of these diets using a pill instead of hunger, the researchers said.

"What we are talking about is potentially having one pill that prevents and even cures many diseases at once," said David Sinclair, a pathologist at Harvard Medical School who helped lead the research.

Sinclair helped found a company that is working on drugs based on this research, Sirtris Pharmaceuticals.

The key is a family of enzymes called sirtuins. They are controlled by genes called SIRT1, SIRT2 and so on.

Last year, researchers showed that stimulating SIRT1 can help yeast cells live longer.

Sinclair, working with colleagues at his company, at Cornell University in New York and the U.S. National Institutes of Health, identified the actions of two more sirtuin genes called SIRT3 and SIRT4.

They found the enzymes controlled by these genes help preserve the mitochondria -- little organs inside of cells that provide their energy.

"These two genes, SIRT3 and SIRT4, they make proteins that go into mitochondria. ... These are little energy packs inside our cells that are very important for staying healthy and youthful and, as we age, we lose them and they get less efficient," Sinclair said in a videotaped statement.

SLOWING EVERYDAY AGING


"They are also very important for keeping the cells healthy and alive when they undergo stress and DNA damage, as we undergo every day during the aging process."

Sinclair and colleagues have found in other studies that even if the rest of a cell is destroyed -- the nucleus and other parts -- it can still function if the mitochondria are alive.

His team found that fasting raises levels of another protein called NAD. This, in turn, activates SIRT3 and SIRT4 in the mitochondria of the cell and these help keep the mitochondria youthful.

"We've reason to believe now that these two genes may be potential drug targets for diseases associated with aging," Sinclair said.

"Theoretically, we can envision a small molecule (pill) that can increase levels of NAD, or SIRT3 and SIRT4 directly, in the mitochondria. Such a molecule could be used for many age-related diseases," he added.

"Diseases like heart disease, cancer, osteoporosis -- even things like cataracts. What we are aiming to do is to find the body's natural processes that can slow down aging and treat these diseases."

Sirtris is already working on such drugs. It has an experimental pill called SRT501, which it is testing in Phase 2a trials in patients with type-2 diabetes.

"These exciting new data further validate sirtuins as attractive targets for drug development to treat diseases of aging," Dr. Christoph Westphal, chief executive officer of Sirtris, said in a statement.
 
Most of this is not new information, buit it is good information.

Our Bodies are made up of Trillions of cells, all developed from the original single cell created when a sperm fertilized an Ovum. This one cell divides into 2, then 4, 8 and so until a small ball if identical cells has formed. Then some cells, under the control of genetic instructions found in their nucleus, start specializing and form the many types of cell – muscle, stomach, pancreas, lung and all the other cell types which make up our body. When we are born, we should have a perfect set of brand new cells. As these cells age or become damaged, they are removed and replaced by new cells. As the instructions in the nucleus have not changed – the new cells should be as good as the very first ones – provided the body has all the raw materials to create perfect cells. A Builder cannot build a perfect house without wood, bricks, nails, glass and other necessary materials. Similarly our body cannot create a perfect cell without the vitamins, minerals, proteins and fats necessary to build it. This is the basis of nutritional medicine.
In fact the news is even better, because all the cells in our bodies (apart from nerve cells) are programmed to have a limited life span after which they are removed and replaced by new cells. Sperm and white blood cells are replaced everyday, stomach cells every 2 days, colon cells every 4 days, skin cells every 3 – 4 weeks, and bone cells every 25 years. Thus every year, apart from our bone and nerve cells – all our cells are brand new. If we feed them correctly, they should be just as good as the very first cells we had when we were babies.
Importantly, if the Tissues are injured by trauma, infection or disease, as these cells are replaced, this damage can be repaired.

The cells also have specialized functions:
Making secretions like saliva and the stomach juices
Making hormones like insulin and adrenaline
Attacking invaders (viruses and bacteria) with white blood cells and the immune system, and the many other complex systems which makes us realize just what a miracle our bodies are.

For the cells to function they need nutrients, the secretions and hormones need the raw materials, the defence system needs antioxidants to help it repair oxidative damage, and the cells themselves need fuel for energy and building materials to work. Compared to the cell, a motor car is much simpler, but without oil, water, petrol grease, it may go – but not for long. Is it surprising then, that the bodies cells do not function well if they are not given all the nutrients they need?

The supporters for Nutritional medicine believe that supplying the body with a complete set of nutrients:
Will enable the body to replace its cells so that they can be as perfect as possible
Enables all the cells to function optimally as they were designed to do.
Can help us defend the body from attack by toxins and free radicals found in our modern polluted world.

1: Toxins in our world – sprays, pesticides, poisons, heavy metals, fumes, smoking and preservatives.
2: Free Radicals are molecules with only one instead of two paired outer electrons. This makes the molecule very unstable and it damages anything it touches. A free radical also attempts to steal an electron from nearby molecules, turning them into free radicals, so causing a chain reaction of damage. This process is called Oxidation.
In addition to the nutrients necessary for the normal function of the cell, our bodies need extra nutritional help to get rid of these toxins and poisons. For example to eliminate excess Lead from the body, we need additional Calcium, Zinc, Selenium, Vitamin C, Flavanoids, and Chromium. To eliminate Mercury we need Selenium, Lipoic acid, Manganese, Chromium, Vanadium. Remember this is over and above our usual daily requirement.

We also know that free radicals causing Oxidative damage are the basis for the development of over 70 different degenerative disease’s, including Heart disease, Arthritis, Cancer & strokes. Antioxidants in our diet (some vitamins, proanthocyanidins and some minerals) are compounds which can donate electrons and neutralize these free radicals so helping the body protect itself.

I strongly believe (and Science strongly show’s) that the body can only function properly when it has all the nutrients it needs. I also believe that today’s polluted world increases the need for more protection, especially from antioxidants. I am also very aware of the poor nutritional content of much of our food. Many of today’s disease’s are caused or aggravated by nutritional deficiency. Improving our Nutrition first and foremost then should therefore help to improve or prevent these conditions.

Because of this I always tell people to eat as well as they possibly can, concentrating on Vegetables (green & coloured), fruits, fish, whole grains, the good fats, seeds & nuts, good quality proteins and lots of pure water. I also recommend people take a top quality Multivitamin/Multi-Mineral (Pharmacutical grade with a 100% potency guarantee) and a good quality fish or flax seed oil supplement to provide the necessary Omega 3 & 6 oils. By doing this the body will receive all the nutrients it needs, from food, supplements or both, and can eliminate what it does not require.
I do not recommend any preparation which contains Iron or Vitamin A, as the body cannot eliminate these.

Vitamin A
This is a fat soluble vitamin and its level can build up in the tissues causing skin problems, bone pain and fractures, nausea, vomiting and weakness. A good vitamin supplement will have Beta-Carotene instead of vitamin A. If the body needs more vitamin A it can convert it from the Beta-Carotene, but if not then the Beta-Carotene is harmlessly excreted.

Iron
This is frequently found in supplement tablets, and for most people it causes no problem. BUT one person in 300 has a condition called Haemochromatosis which means that the Iron will continue to build up in the body tissues, especially the Liver, Pancreas, and the Heart, leading to Cirrhosis, Diabetes and Heart failure – which can be fatal. Unfortunately only a special blood test can confirm the presence or absence of Haemochromatosis, so to include Iron in a routine supplement could potentially kill or maim one in 300. Some people do need Iron (for Anemia), but it should be taken as a separate tablet, and only after a blood test has confirmed that there is a need.

When it comes to buying Nutritional supplements, Quality is of the utmost importance. The supplement must be in a formulation which is easy to assimilate into the body and easy to eliminate if it is surplus to requirements.
This means the supplement must be carefully chosen, contain the correct amount and balance of nutrients and be in a formulation which is easy for the body to absorb and excrete. We have to rely on the Manufacturers to do this for us, and unfortunately most supplements are only Manufactured to Food grade Quality and have no Potency guarantee and only supply us with the RDA, to help prevent Acute Defiency Disease’s, RDA’s do nothing in the prevention of Degenerative disease’s.
Much of the professional resistance to the use of dietary supplements results from the use of poor quality supplements in the past. Consistently high quality supplements are available, and these do make a real difference to one’s health and recovery.

Dr Gerald Lewis MB ChB, FRCP, FRACP, MD
Dr B Monica Lewis MB, ChB
 
this is silly to me

if you want to live longer you need to eat a diet rich in organic foods that are alive.. this will suply many anti oxidants that will scavenge up free radicals and keep you youthfull... its that easy folks!

this imo is a technique used by big pharma to make money off us, you cant put a patent on fruits and veggies so they will develop some new 'drug' they can sell for 100x the cost and rape all us foolish consumers......

eating alow calore diet has been proven to help you maintain your health and live longer, you dont need a study to tell us that....

they dont want to heal you they want to treat you.... it makes no sense to develop drugs that will cure us of diseases, but it does make sense to develop drugs to treat our illnesses... there is too much money to made in disease treatment.......
 
KM2000 i totally agree, the most important thing we can do is to have a good balanced diet, but this is extremly hard for most people, and just to give an example.

400IU of Vitamin E is seen as an optimal daily dose for optimal health, to get this from food we would need to consume up to 15kg (32p) of Spinach a day, or maybe a Kg (2.2p) of almonds every day or we could drink a litre of safflower oil, this is just for Vitamin E, not all the other minerals and anti-oxidants we need on a daily basis for optimal cellular health.
 
this is silly to me

if you want to live longer you need to eat a diet rich in organic foods that are alive.. this will suply many anti oxidants that will scavenge up free radicals and keep you youthfull... its that easy folks!

this imo is a technique used by big pharma to make money off us, you cant put a patent on fruits and veggies so they will develop some new 'drug' they can sell for 100x the cost and rape all us foolish consumers......

eating alow calore diet has been proven to help you maintain your health and live longer, you dont need a study to tell us that....

they dont want to heal you they want to treat you.... it makes no sense to develop drugs that will cure us of diseases, but it does make sense to develop drugs to treat our illnesses... there is too much money to made in disease treatment.......


I feel the same way. If anything, they are just looking for a way to extend your life so that they can make more money off of the longer you use these drugs.
 

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