orals and bioavailability

[Sanctus Umbra]

In his book,anabolics 2007,llewellyn suggests taking all orals on an empty stomach to increase their bioavailability.Any reason why this method works better than if taking them after meals?

 

[Jarconis]

Well, im sure any fats that you eat before that are sitting in your tum-tum may possibly slow absorption, just a guess.

 

[norm1220]

For maximum bioavailbility, take your orals with grapefruit juice.

 

[SitySlicker1]

For maximum bioavailbility, take your orals with grapefruit juice.

Why grapefruit juice? For insulin spike?

 

[norm1220]

http://www.medicinenet.com/script/main/art.asp?articlekey=14760

The 3rd paragraph pretty much sums up why it make drugs more bioavailable.

 

[GoneForever]

http://www.medicinenet.com/script/main/art.asp?articlekey=14760

The 3rd paragraph pretty much sums up why it make drugs more bioavailable.

Wow, I always thought you could take orals whenever with whatever. How much grapefruit juice do you think is necassary? 4oz?

 

[SitySlicker1]

Good read Norm, thanks. Been downing powder orals w/ crystal lite first thing in the morning. After reading this article, gonna give grapefruit juice a try.

 

[BrooklynBB]

For maximum bioavailbility, take your orals with grapefruit juice.

Good read, and you don't even have to take it with the orals if you don't want to since the effects of the enzyme blocking lasts 24 hours according to the link you provided:

"...grapefruit juice does not have to be taken at the same time as the medication in order for the interaction to occur. Therefore, unlike similar interactions, where the interaction can be avoided by separating the administration of the two interacting agents by a couple of hours, administration of grapefruit juice with susceptible drugs should be separated by 24 or more hours to avoid the interaction."

Feasibly, you could take it at some point during the night before and the effects will stay with you for about 24 hours. I mention this in case anyone is under the impression that you have to gulp down grapefruit juice every time you pop a med to get the effect. That isn't necessary.

 

[GoneForever]

Sweet, all day long it lasts. I wonder how much grapefruit juice must be taken to be effective all day.

Good read, and you don't even have to take it with the orals if you don't want to since the effects of the enzyme blocking lasts 24 hours according to the link you provided:

"...grapefruit juice does not have to be taken at the same time as the medication in order for the interaction to occur. Therefore, unlike similar interactions, where the interaction can be avoided by separating the administration of the two interacting agents by a couple of hours, administration of grapefruit juice with susceptible drugs should be separated by 24 or more hours to avoid the interaction."

Feasibly, you could take it at some point during the night before and the effects will stay with you for about 24 hours. I mention this in case anyone is under the impression that you have to gulp down grapefruit juice every time you pop a med to get the effect. That isn't necessary.

 

[BrooklynBB]

To answer your question specifically, FourthGen, I found this on another site:

"How much grapefruit juice does a person have to drink to cause a problem?

It varies by individual and medication."

So there you go. I'm sure that a glass the night before should be enough to block the enzyme. But be careful, since clearly in the article it states that the potency is increased significantly to the point where organs may be over stressed to a high degree.

This may clue us in as to why certain people respond to orals negatively - they have lower levels of the enzyme naturally and thus have all types of problems, while others can take more of the substance and have no liver / kidney issues but a high degree of anabolic responsiveness.

 

[2Sick]

have you ever taken an Anadrol or a couple winny tabs on an empty stomach? I know it makes me feel sick. I wouldnt seggest it.

I herd about the grapefruit juice thing a while ago, wasnt there a warning about taking it with curtain medications non AAS?

 

[chadahoochie02]

what exactly in grapefruit juice causes the reaction, im really against simple carbs unless pwo... obv.. anyone know any alternatives, thanks.... ps simple sugars are just to goddamn sweet these days anyways

ie: what vitamin etc

 

[GoneForever]

Well, I think the amount is gonna be hard to tell, so I usually take my oral's 2x per day. So im thinking i'll take 4oz of %100 pure white grapfruit juice 2x per day with the orals. Hopefully thats best.

 

[chadahoochie02]

do they make sugar free, and would it be the same? anyone know the nutrient?

 

[nosmas]

to CHEW...or not to CHEW, that is my question

On this subject, I want to ask you guys who chew your tabs (I have only heard of this in regards to d-bol, a-drol) is that specific to the drug, or manufacturer?

 

[GoneForever]

On this subject, I want to ask you guys who chew your tabs (I have only heard of this in regards to d-bol, a-drol) is that specific to the drug, or manufacturer?

I think this is only necassary with IP tabs.

 

[nosmas]

I think this is only necassary with IP tabs.

Thanks!