Proviron (Mesterolone) was used in INJECTION form as an anti-depressant, not just oral.

[Vision]

Mesterolone as an anti-depressant even as INJECTION form.. That's right, Mesterolone was once used anti-depressant in INJECTION form, as most of us know it was used in the oral application for the same intent..
One will argue that Masteron (Drostanolone) is the same, it's NOT..

Here's some old info that we all may know, yet below is some info about it's short term use in oily form..

The German hormone manufacturer Schering did tests in the seventies on an injectable analogue of the anabolic steroid mesterolone, the active substance in Proviron. We, the industrious compilers of this free webzine, discovered this friday afternoon when we were browsing through patents. Researchers at Schering gave mesterolone cypionate and classic mesterolone to men suffering from depression – and the results were promising.
Mesterolone
Mesterolone resembles DHT, the androgen metabolite of testosterone. The difference with DHT is that mesterolone has a methyl group on C1 and DHT does not. The methyl group makes mesterolone into a very mild steroid. So mild that, according to studies done in the 1970s, oral doses of 75-150 g daily have a negligible effect on the body's own testosterone synthesis.
https://pubmed.ncbi.nlm.nih.gov/4418512/
At the same time the 1-alpha-methyl group inhibits enzymes that neutralise mesterolone in the body. That's why mesterolone can be taken orally.
Most handbooks say that mesterolone is too mild for male steroids users. In the past steroids users have taken mesterolone as an anti-oestrogen but without much success, and to restart the body's own testosterone production after a course of steroids - with even less success.
Mesterolone as an anti-depressant

In the 1980s researchers at Schering published a couple of studies in which they had got small groups of men suffering from depression to take 300-450 mg mesterolone daily for a period of six weeks.
https://pubmed.ncbi.nlm.nih.gov/6431212/
This treatment was successful in most of the subjects.

In another study the researchers compared mesterolone with the anti-depressant amitriptyline.

https://pubmed.ncbi.nlm.nih.gov/3880735/
http://According to the researchers...tive, but mesterolone had fewer side effects.

Mesterolone cypionate
Schering's research on the anti-depressive effect of mesterolone started in the 1970s, as the discovery of a patent dating from 1974 shows.
https://patents.google.com/patent/US3908007

In that patent the researchers explicitly mention mesterolone and its esters, one of which was named mesterolone cypionate [structural formula shown below].

According to the patent, mesterolone cypionate is particularly suitable for oral use, but can be injected too.
The patent also happens to cover the use of nearly all possible analogues of mesterolone as anti-depressants. The figure below gives an idea of the dosages that the researchers used.

Mesterolone as a stimulant
According to the patent, the researchers administered mesterolone and its esters to subjects in both low and high dosages. The high dosages, shown above, had an anti-depressant effect, and the low dosages a stimulatory effect. The stimulatory dose for mesterolone administered orally lies somewhere between 1 and 20 mg, according to the patent.
"It has now been found that mesterolone and its esters exhibit a psychostimulating effect at lower doses", the researchers wrote. "The desired psychotropic and CNS-stimulating effects of mesterolone occur within 2-3 hours after administration."
Source:
https://patents.google.com/patent/US3908007

 

[Truckman]

very little is bio available in oral form. believe 3%

 

[Vision]

very little is bio available in oral form. believe 3%

Do you have any proof for this because I seen from studies that lasted years on years... Further more its methyl 1α-Methyl-4,5α-dihydrotestosterone; 1α-Methyl-DHT; 1α-Methyl-5α-androstan-17β-ol-3-one. It will have a higher bio availability.. ration..

 

[Truckman]

Do you have any proof for this because I seen from studies that lasted years on years... Further more its methyl 1α-Methyl-4,5α-dihydrotestosterone; 1α-Methyl-DHT; 1α-Methyl-5α-androstan-17β-ol-3-one. It will have a higher bio availability.. ration..

google Proviron bio-availability, it's clearly defined on the product information data by Bayer.

 

[Vision]

google Proviron bio-availability, it's clearly defined on the product information data by Bayer.

I seen the Google , it has always shown 3%
I assumed you had some other information.
My reasons for asking. I have seen on data 2-4% was wondering where you got 3%
Thank you for clarifying.

 

[rdm]

Proviron is a staple for me. I love overall felling of well-being.

 

[3BILLS]

I snort my Proviron

 

[MyNameIsJeff]

OP plagiarized from this article: https://www.ergo-log.com/mesterolone-as-an-anti-depressant-and-pep-pill.html

But with worse formatting and the usual insufferable style.

 

[A50#]

I snort my Proviron

I take mine as a rectal suppository

 

[aHarness]

I seen the Google , it has always shown 3%
I assumed you had some other information.
My reasons for asking. I have seen on data 2-4% was wondering where you got 3%
Thank you for clarifying.

3% is in the middle of 2-4%

 

[luki7788]

this is what the theory and research say and I'm not saying it's not true but every time I add proviron to the stack even 50mg in a few days my physics gets drier, doses of 150-200mg a day for me make a huge difference in appearance if %bf is low enough

 

[Doitagain]

this is what the theory and research say and I'm not saying it's not true but every time I add proviron to the stack even 50mg in a few days my physics gets drier, doses of 150-200mg a day for me make a huge difference in appearance if %bf is low enough

Never, ever did anything remotely detectable for my appearance even at very high doses, no matter my B.F. %
That being said, I like it and use it year round because I DO feel its effects on my mood and overall "wellbeing".

 

[Stewie]

Never, ever did anything remotely detectable for my appearance even at very high doses, no matter my B.F. %
That being said, I like it and use it year round because I DO feel its effects on my mood and overall "wellbeing".

Same here.

 

[bbxtreme]

this is what the theory and research say and I'm not saying it's not true but every time I add proviron to the stack even 50mg in a few days my physics gets drier, doses of 150-200mg a day for me make a huge difference in appearance if %bf is low enough

I’m in the same camp. I wouldn’t want to compete without it. Once you’re at this range for a few weeks the fullness really pairs perfectly with the hard and dry look that high winstrol gives.

 

[mexbeast]

It would be nice to have access to the cyp inject!

 

[Gunsmith]

Never, ever did anything remotely detectable for my appearance even at very high doses, no matter my B.F. %
That being said, I like it and use it year round because I DO feel its effects on my mood and overall "wellbeing".

What dose do you use ti see these effects.

 

[Doitagain]

What dose do you use ti see these effects.

Effects on mood and wellbeing are pretty noticeable for me at 50-75mg/day
Fullness/hardness, not even at 300mg. I get more from 10mg winny or 20mg Mast a day, no joke.

 

[swoleup57]

If I’m not mistaken I believe key tech use to carry an inject Proviron and also inject dht. Not sure if still do.

 

[Unluckyscience]

Why not dissolve it in dmso and apply it on scortum? Testosterone base in dmso applied to scortum has almost 100% bioavailability.

 

[mexbeast]

Why not dissolve it in dmso and apply it on scortum? Testosterone base in dmso applied to scortum has almost 100% bioavailability.

For me at least, DMSO is unusable, it irritates and burns my skin, can't imagine applying it to my sack