SHBG doesn’t really matter.

[Jacked_]

After my third time watching this video I’m starting to get a much better understanding on the topic. A lot of people are way too worried about nuking their SHBG for “more gains” when this is a pretty dumb approach.

The biggest takeaway is that there’s a big difference between “free testosterone” and “bioavailable testosterone”. Just because testosterone is bound to SHBG it doesn’t mean it’s “useless” in fact a guy with an SHBG of 30 will grow more muscle than the guy with an SHBG of 10. Testosterone can and will become unbound from SHBG in the muscle cell nucleus and will have no issue binding to the AR. I have been confused about this for a long time, and there’s a lot of misconceptions about the true purpose of SHBG, it’s not a bad thing at all. It’s taking the hormones to where they need to go.

 

[Stewie]

Here's some scant discussion on your queries. If your curiosity piques your interest, digest information on endocytosis and megalin interrelationship, namely
endocytic receptor.

https://www.professionalmuscle.com/forums/index.php?threads/what-compound-shocked-you.177583/page-14#post-3291328

https://www.professionalmuscle.com/forums/index.php?threads/esterfied-gear-activation-breakdown-use.165938/#post-2879698

https://www.professionalmuscle.com/forums/index.php?threads/do-esters-change-how-the-hormones-react-in-the-body.164725/#post-2832065

https://www.professionalmuscle.com/forums/index.php?threads/who-here-uses-used-proviron-what-did-you-see.166539/page-2#post-2904592

There's other threads. I think that's enough for now.

 

[Jacked_]

Here's some scant discussion on your queries. If your curiosity piques your interest, digest information on endocytosis and megalin interrelationship, namely
endocytic receptor.

https://www.professionalmuscle.com/forums/index.php?threads/what-compound-shocked-you.177583/page-14#post-3291328

https://www.professionalmuscle.com/forums/index.php?threads/esterfied-gear-activation-breakdown-use.165938/#post-2879698

https://www.professionalmuscle.com/forums/index.php?threads/do-esters-change-how-the-hormones-react-in-the-body.164725/#post-2832065

https://www.professionalmuscle.com/forums/index.php?threads/who-here-uses-used-proviron-what-did-you-see.166539/page-2#post-2904592

There's other threads. I think that's enough for now.

Thank you for this

 

[Jacked_]

I accidentally linked the following video nice. Meant to link this..

 

[3BILLS]

Welcome to the party. Your a little late though

 

[Jacked_]

Welcome to the party. Your a little late though

Oh man I’ve been reading the links. I’m wayy behind

 

[aHarness]

People care what their SHBG is?…

 

[luki7788]

After my third time watching this video I’m starting to get a much better understanding on the topic. A lot of people are way too worried about nuking their SHBG for “more gains” when this is a pretty dumb approach.

The biggest takeaway is that there’s a big difference between “free testosterone” and “bioavailable testosterone”. Just because testosterone is bound to SHBG it doesn’t mean it’s “useless” in fact a guy with an SHBG of 30 will grow more muscle than the guy with an SHBG of 10. Testosterone can and will become unbound from SHBG in the muscle cell nucleus and will have no issue binding to the AR. I have been confused about this for a long time, and there’s a lot of misconceptions about the true purpose of SHBG, it’s not a bad thing at all. It’s taking the hormones to where they need to go.

show me someone who uses gear (not real TRT) and has SHGB in the norm lol

 

[Doitagain]

Here's some scant discussion on your queries. If your curiosity piques your interest, digest information on endocytosis and megalin interrelationship, namely
endocytic receptor.

https://www.professionalmuscle.com/forums/index.php?threads/what-compound-shocked-you.177583/page-14#post-3291328

https://www.professionalmuscle.com/forums/index.php?threads/esterfied-gear-activation-breakdown-use.165938/#post-2879698

https://www.professionalmuscle.com/forums/index.php?threads/do-esters-change-how-the-hormones-react-in-the-body.164725/#post-2832065

https://www.professionalmuscle.com/forums/index.php?threads/who-here-uses-used-proviron-what-did-you-see.166539/page-2#post-2904592

There's other threads. I think that's enough for now.

Recommended reading:

https://www.cell.com/cell/fulltext/S0092-8674(05)00651-3?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867405006513%3Fshowall%3Dtrue

 

[Blackdream]

Here's some scant discussion on your queries. If your curiosity piques your interest, digest information on endocytosis and megalin interrelationship, namely
endocytic receptor.

https://www.professionalmuscle.com/forums/index.php?threads/what-compound-shocked-you.177583/page-14#post-3291328

https://www.professionalmuscle.com/forums/index.php?threads/esterfied-gear-activation-breakdown-use.165938/#post-2879698

https://www.professionalmuscle.com/forums/index.php?threads/do-esters-change-how-the-hormones-react-in-the-body.164725/#post-2832065

https://www.professionalmuscle.com/forums/index.php?threads/who-here-uses-used-proviron-what-did-you-see.166539/page-2#post-2904592

There's other threads. I think that's enough for now.

Great info

 

[Pizza15]

Why people over complicates everything, just inject Test and GTFO..... None that takes gear has a "normal" SHBG. Yet they all grow from high test....

 

[slesh]

What’s SHBG?

 

[bbxtreme]

What’s SHBG?

Fair question… on that 2500mg of test you run you probably have never heard of it because you don’t have any.

 

[slesh]

Fair question… on that 2500mg of test you run you probably have never heard of it because you don’t have any.

No clue what you’re talking about

 

[bbxtreme]

No clue what you’re talking about
View attachment 201902

Damn and I thought I kept my numbers high. But hey >2 - I was close! lol

We need to get that Estradiol down though. Hopefully you’ve added some adex.

 

[slesh]

Damn and I thought I kept my numbers high. But hey >2 - I was close! lol

We need to get that Estradiol down though. Hopefully you’ve added some adex.

No way. I don’t aromatize. Been as high as 200 with nothing. These labs were prior to me adding Primo anyways so I should be under 100 at least.

 

[bbxtreme]

No way. I don’t aromatize. Been as high as 200 with nothing. These labs were prior to me adding Primo anyways so I should be under 100 at least.

I figured you had it covered. Just a habit. I read so much blood work around this stuff it’s like second nature. Everybody has their sweet spot. I look good and feel good at 30-40. Others it’s much higher.

 

[slesh]

I figured you had it covered. Just a habit. I read so much blood work around this stuff it’s like second nature. Everybody has their sweet spot. I look good and feel good at 30-40. Others it’s much higher.

Absolutely. I’ve found that if I pin daily and keep my BF low I can run any Test dose without an AI and be fine. I generally have a low dose of Primo, Proviron or even Var to help suppress a little to be safe.

 

[Hammer4]

Why people over complicates everything, just inject Test and GTFO..... None that takes gear has a "normal" SHBG. Yet they all grow from high test....

Oh the irony

 

[Doitagain]

I figured you had it covered. Just a habit. I read so much blood work around this stuff it’s like second nature. Everybody has their sweet spot. I look good and feel good at 30-40. Others it’s much higher.

On a side note, just to stay on topic, a decent E2 level (and good thyroid hormones values too) help not to bring SHBG to zero.