SHBG doesn’t really matter.

[madg]

Damn and I thought I kept my numbers high. But hey >2 - I was close! lol

We need to get that Estradiol down though. Hopefully you’ve added some adex.

Isnt 4,7 k low for 2,5 g test ?

I pulled 8k on 1 g Norma enanthate

 

[Doitagain]

Isnt 4,7 k low for 2,5 g test ?

I pulled 8k on 1 g Norma enanthate

You may still have a reasonable SHBG level.
SHBG decreases the metabolic clearance rate of testosterone. So in other words, the lower the SHBG, the faster the Testosterone excretion.
Of course with large dosages and frequent administration you can still gain plenty even with SHBG in the gutter, this doesn't mean it's optimal tho.

 

[totalrecomp]

Why people over complicates everything, just inject Test and GTFO..... None that takes gear has a "normal" SHBG. Yet they all grow from high test....

Some of us have an interest in the details and "nitty gritty" science stuff. I can only speak for myself but LEARNING beats staring at the wall of my cave all day, but to each their own. I apologize for spending MY TIME in a manner not approved by you, random person on the internet, I'll work on it.

 

[bbxtreme]

Isnt 4,7 k low for 2,5 g test ?

I pulled 8k on 1 g Norma enanthate

What @Doitagain said. Generally for “bodybuilders” we want to keep it on the low end. Take it all the way to zero… no, but for us low = good.

Keep in mind @slesh just changed cycles so his numbers will be adjusting. He went from a low test cut to now a high test rebound.

 

[madg]

Thanks for spoonfeed @bbxtreme and @Doitagain

It make sense

 

[Jacked_]

Recommended reading:

https://www.cell.com/cell/fulltext/S0092-8674(05)00651-3?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867405006513%3Fshowall%3Dtrue

Thanks for this.

 

[Dog-Slime]

Recommended reading:

https://www.cell.com/cell/fulltext/S0092-8674(05)00651-3?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867405006513%3Fshowall%3Dtrue

Im confused , would increasing megalin make bound to shbg test still effective? And if so, how can we?

 

[Stewie]

Both -megalin and SHBG are gene regulated. As the hypothesis stands, they create a complex (bond) between the two that gives way for docking and internalization (endocytosis) of several different proteins, molecules and vitamins to their respective receptors. Megalin isn't specific to just sex hormone transfer, such as androgens to AR.

The raw materials for SHBG and megalin are produced within the endoplasmic reticulum (ER) that creates a transmembrane around different cell types. This is in the context of megalin.

As for SHBG, these ER's take-up residents within hepatocytes. Purposely, theses ER's perform several different biochemical reactions. One of the primary functions is for detoxification, proper protein folding, ect.

You asked what can be done to increase (upregulation) of megalin. Rather than using the philosophy of increasing gene expression (epigenetic stimuli), be mindful of what you can do to put the brakes on damage control on these ER's - hepatocytes.

 

[Stewie]

Both -megalin and SHBG are gene regulated. As the hypothesis stands, they create a complex (bond) between the two that gives way for docking and internalization (endocytosis) of several different proteins, molecules and vitamins to their respective receptors. Megalin isn't specific to just sex hormone transfer, such as androgens to AR.

The raw materials for SHBG and megalin are produced within the endoplasmic reticulum (ER) that creates a transmembrane around different cell types. This is in the context of megalin.

As for SHBG, these ER's take-up residents within hepatocytes. Purposely, theses ER's perform several different biochemical reactions. One of the primary functions is for detoxification, proper protein folding, ect.

@Dog-Slime You asked what can be done to increase (upregulation) of megalin. Rather than using the philosophy of increasing gene expression (epigenetic stimuli), be mindful of what you can do to put the brakes on damage control on these ER's - hepatocytes.

Edit^

 

[Doitagain]

Both -megalin and SHBG are gene regulated. As the hypothesis stands, they create a complex (bond) between the two that gives way for docking and internalization (endocytosis) of several different proteins, molecules and vitamins to their respective receptors. Megalin isn't specific to just sex hormone transfer, such as androgens to AR.

The raw materials for SHBG and megalin are produced within the endoplasmic reticulum (ER) that creates a transmembrane around different cell types. This is in the context of megalin.

As for SHBG, these ER's take-up residents within hepatocytes. Purposely, theses ER's perform several different biochemical reactions. One of the primary functions is for detoxification, proper protein folding, ect.

You asked what can be done to increase (upregulation) of megalin. Rather than using the philosophy of increasing gene expression (epigenetic stimuli), be mindful of what you can do to put the brakes on damage control on these ER's - hepatocytes.

Not surprisingly, the ER chemical chaperone TUDCA attenuates endoplasmatic reticulum stress, prevents unfolded protein response dysfunction, and stabilizes mitochondria.

 

[Stewie]

Not surprisingly, the ER chemical chaperone TUDCA attenuates endoplasmatic reticulum stress, prevents unfolded protein response dysfunction, and stabilizes mitochondria.

A natural occurring compound in a specific type of Ginger looks pretty promising on realigning ER dynamics. Namely, - Zerumbone. There's several other nutraceuticals and pharmaceuticals that purportedly assist in organelles dynamics.

If we know we're living a lifestyle that potentially has damaging effects on our liver. We can be readily certain those ER's tucked away in hepatocytes are being inundated with stress. As well, every other chaperone and organelles compartmentalized within the cytosol.

 

[Parabolic33]

show me someone who uses gear (not real TRT) and has SHGB in the norm lol

I do but I use a special protocol. I’m in the video linked earlier. I found out by accident that shbg increases if compounds with low shbg relative binding affinity are used, then shbg comes up.

So this rules out a testosterone base- because dht has a 100% rba to shbg and testosterone possibly 70%

I’ve done deca only with exogenous estradiol enanthate to replace the e2 missing by not having test. This was my first experience seeing this. I’ve since gone on to do this with primo,eq, primo+eq, tren+mast+ winstrol, tren + winstrol and many other combinations.

I don’t find the missing dht to cause anything noticeable for me.

Like I discussed in the video with Todd and Kurt, I found measurable uptick in progress as measured by body part measurements and scale weight while shbg was above 15nmol/L and a reduced rate of growth and progress using the same weekly dose of aas and same protocol/diet etc when shbg was in the single digits.

I’m only one person, but I’m having a few others who’ve approached me interested in trying it- but what I really would like is to see this work with somebody who’s already very large.

I’m not very large yet. But I have grown from 128 to 240lb with abs after only lifting 2.5 years. In terms of stage weight, the last time I dieted down to that was 9 months ago and I was 190lb with striated glutes. So I’d grown from 128 to 190lb in stage conditioning in In 23 months of lifting. But I’m currently dieting down again 10 weeks in and I’m around 18-20lb heavier than what I was at my previous diet 9 months ago at this stage. But I still have a little ways to go maybe 4-5 more weeks of diet to be able to say with some confidence how much stage quality weight I’ve gained over the last 9 months.

 

[Parabolic33]

I accidentally linked the following video nice. Meant to link this..

Yay it’s me. Don’t worry I’m much bigger now..

 

[Zarati]

SHBG does matter, it's just that too much or too low is not good.

 

[Doitagain]

SHBG does matter, it's just that too much or too low is not good.

Nah, it's just some casual shit Evolution threw in your body randomly as the trash bin was full

 

[Zarati]

Nah, it's just some casual shit Evolution threw in your body randomly as the trash bin was full

God was drunk

 

[LATS]

show me someone who uses gear (not real TRT) and has SHGB in the norm lol

True.. even with my lower dose use I'm at 6.. of course some compounds are are bit harder on shbg than others but once you get to a certain mg amount it's going to tank shbg

 

[m302_imola]

The beauty of hrt is it brings SHBG levels down naturally, thus creating more bioavailabile test. Notice I said lowers SHBG, and not tanks it to zero.

This makes a huge difference in my physique as I have labs where I was naturally producing around 900ng/dL test (endogenously) and SHBG levels were 40nmol/L verse the hrt route (200mg cyp/week) and test levels remained the same (900ng/dL) but SHBG was superseded to 20nmol/L and my physique was fuller, harder, drier on hrt. Just test only took care of that. I might add that estrogen levels remained the same through both trials which was dead smack middle of the range. To me this is the beauty of hrt. And I’ll also add that my sex drive was higher on hrt, which I attribute mostly to more bioavailabile test.

 

[Parabolic33]

The beauty of hrt is it brings SHBG levels down naturally, thus creating more bioavailabile test. Notice I said lowers SHBG, and not tanks it to zero.

This makes a huge difference in my physique as I have labs where I was naturally producing around 900ng/dL test (endogenously) and SHBG levels were 40nmol/L verse the hrt route (200mg cyp/week) and test levels remained the same (900ng/dL) but SHBG was superseded to 20nmol/L and my physique was fuller, harder, drier on hrt. Just test only took care of that. I might add that estrogen levels remained the same through both trials which was dead smack middle of the range. To me this is the beauty of hrt. And I’ll also add that my sex drive was higher on hrt, which I attribute mostly to more bioavailabile test.

Higher libido is generally the trend with more free testosterone( lower shbg). However I’ve read and talked with people where this seems to go the other way once shbg gets below a critical low level.

Shbg, Sort of like and analogy to e2: when e2 has been too high for a while, then somebody lowers e2 and gets into their sweet spot, libido and performance is improved for some. ( personally higher e2 seems to result in more libido and I haven’t reached a level where that seems to taper off yet- Individual differences)
… this too seems to happen when guys over do proviron sometimes in the search for more libido- the proviron works and gives them what they’re looking for, so they keep taking it and report it stops working and their libido can end up being worse that what they started at.

 

[luki7788]

If low SHBG was something bad that doesn't prevent you from growing, then according to this theory I would still be 200 lbs because since I started gear and started doing blood tests I've always had critically low levels just like all the biggest guys I know