I use 2ml synthergine AM/PM when on orals. That is great for me and at that dose the whites of my eyes go really bright. When I am off orals I may lower the dose slightly to make the bottle last longer. I have breaks from everything but run synthergine approx 9 months per year. I am also a fan of LIV-52 DS for an all year round liver aid. I also like to drink plenty of lemon water.