Test E/Finasteride Study

[Emery]

Testosterone enanthate works just as well when you take finasteride too


Testosterone enanthate injections build just as much muscle mass and power if you take finasteride at the same time. At least: they did in this study of over 65s who injected 200 mg testosterone once a fortnight. And before you ask: no, the researchers were not on the payroll of a pharmaceuticals company. They were paid by the American government.

Testosterone converts into the androgen DHT in the body. Many undesirable side effects of testosterone, such as acne, hair loss, increased aggression, an enlarged prostate and the increased chance of prostate cancer associated with this, are to a large extent the work of DHT.

The enzyme 5alpha-reductase is responsible for converting testosterone into DHT. Finasteride blocks this enzyme. In test tube studies, DHT attaches better to the androgen receptor than testosterone. If you block 5alpha-reductase with finasteride, is testosterone still anabolic? Yes, in animal studies. And in humans? That’s the question these researchers wanted to answer.

So they gave 70 men, all of whom had a low T level, a placebo, testosterone enanthate, or testosterone enanthate plus 5g finasteride, for a period of three years.

Adding finasteride to the testosterone did not have a protective effect on the prostate. But this probably would have been the case if the men had taken higher doses of testosterone.

If less testosterone is converted into DHT, it would seem to be a reasonable assumption that more testosterone is being converted into estradiol. And, lo and behold, that’s what happens – after six months.

So chemical athletes who are worried about the androgenic effects of taking testosterone could use finasteride, you could conclude from the study. The addition of finasteride either does not reduce the muscle building effect of testosterone, or it only does so minimally. A possible downside for athletes, certainly if they take finasteride over an extended period of time, is that finasteride raises estradiol levels. And that increases the chance of developing gyno.

 

[dr intensity]

finestaride raises estradiol how?

 

[aphextwin]

That is a very interesting post. Thanks

 

[pittsburgh]

gyno is a listed side effect of both Finasteride(propecia/proscar) and Durasteride(Avodart).

Testosterone can convert into either DHT or Estradiol. If you block the DHT conversion then more Test is available to be converted to Estrogens.

 

[dr intensity]

gyno is a listed side effect of both Finasteride(propecia/proscar) and Durasteride(Avodart).

Testosterone can convert into either DHT or Estradiol. If you block the DHT conversion then more Test is available to be converted to Estrogens.

ok that ways .... fine i got it... thanks

 

[animalsd]

So would taking exemestane and finasteride block both the DHT and Estradiol?

If so, is there any problems with taking both of them together?

 

[Newman]

So would taking exemestane and finasteride block both the DHT and Estradiol?

If so, is there any problems with taking both of them together?

I was wondering the same thing...

 

[mrgsxr]

So would taking exemestane and finasteride block both the DHT and Estradiol?

If so, is there any problems with taking both of them together?

Bump for this question.

 

[ICU11b]

Can you post a link to the full research article? Interesting read. Thank you

 

[juicin]

So would taking exemestane and finasteride block both the DHT and Estradiol?

If so, is there any problems with taking both of them together?

I personally always take Finasteride and exemestane together whenever on cycle.

2.5mg of Finasteride and 15mg exemestane everyday.

 

[Kaladryn]

So would taking exemestane and finasteride block both the DHT and Estradiol?

If so, is there any problems with taking both of them together?

There is a study on dogs given both an AI and a 5ARI, they found the combination of both caused massive BPH. This is unfortunate because the study was poor designed, and inhibiting both E2 and DHT is the future of treating prostate issues. The problem with the study is that they gave high enough doses to completely block all DHT and E2, on lower doses I doubt they would have seen the massive BPH they saw.

About the OP above, there is absolutely no doubt that inhibiting 5AR will reduce the effect you get from test. Reduction in strength gains is the most noticable effect.

And the theory, "all testosterone is either reduced or aromatized, and blocking one will increase the other" is doctor propagated broscience. Studies have shown a slight increase in testosterone on finasteride and a very slight increase in estradiol. The increase is so slight there is no reason to think the extra E2 is from anything but the extra test.

 

[Jarconis]

yeah, to what Kala said, giving 5mg of finasteride for 200mg of test is like using a mortar to go deer hunting.

 

[cpesloco]

I would like to read this study as well. I have noticed some weight gain and the only thing that has changed is taking Finasteride. It makes total since now reading your post.

 

[10brandonr]

Yup using an 5ar-inhibitor along side an AI will dramatically increase testosterone levels. DHT is not a particularly anabolic hormone, so it only makes sense that by increasing test concentrations, we can actually make our cycles equally effective if not more effective by adding something like dutasteride. This could probably be applied to any other steroid metabolized by 5-alpha reductase, which would explain why some notice that the use of a 5ar-inhibitor complicates MPB in nandrolone users. It is actually increasing concentrations of the more anabolic parent hormone and its other metabolites, than the rather inert DHN.

 

[Emery]

www.ergo-log.com

This is the site I got the study from. There are many studies on it that have to do with ergogenic aids, etc.

It's a cool site... Not all studies apply but it is referenced...