Your cruise dose

[Keefs]

I know you asked cruise but as a reference my strict TRT is 200mg weekly of test C 1x per week. Puts me 1100 serum top of range at peak then drops lower rest of. Was dr prescribed and monitored for years but I just do it myself now.

I am seriously thinking of doing the same thing. I’ve been seeing an endo for the last 13 years. He does a decent job and didn’t hesitate to prescribe me 200mg a week, but honestly, I’m positive I can just do a better job by myself. I get a full blood panel done every 3 months outside of what he does Lol. He usually just checks my test levels and that’s it. Also, if I gain any weight at all he’s like,”Oh, I see you’ve put on some weight!” It’s a little annoying but I think doctors say that to every patient whether they are on trt or not. They like for us to be in the “healthy” weight range. I think I’ve been told many times that I was obese haha! Even though you can clearly see my abs!

 

[pistonpump]

I am seriously thinking of doing the same thing. I’ve been seeing an endo for the last 13 years. He does a decent job and didn’t hesitate to prescribe me 200mg a week, but honestly, I’m positive I can just do a better job by myself. I get a full blood panel done every 3 months outside of what he does Lol. He usually just checks my test levels and that’s it. Also, if I gain any weight at all he’s like,”Oh, I see you’ve put on some weight!” It’s a little annoying but I think doctors say that to every patient whether they are on trt or not. They like for us to be in the “healthy” weight range. I think I’ve been told many times that I was obese haha! Even though you can clearly see my abs!

I think this is why a good coach is better then a doctor for our use. I mean someone who has been in this lifestyle and learned blood work and compounds and has access to rx meds is way better then Dr who barely knows a thing about the details of steroid use and exercise lifestyle

 

[Type-IIx]

I was requested by PM to address the claim that androgen receptor (AR) "resensitization" is a rationale for discontinuing AAS, meaning that supraphysiologic androgen dose (AUC; nmol * h/L) induces tachyphylaxis (desensitization) analogous to opioid/opiate & Opioid Receptors (i.e., κ-, δ-, μ- OR) or clenbuterol & β₂Adrenergic Receptors (B2AR). Since I have some time and think that this is important, I will oblige.

Tachyphylaxis or desensitization is a feature of G-protein-coupled receptors (GPCRs) that AR is not. In the case of opioid/opiate drugs, the μ- OR is a GPCR subject to phosphorylation that recruits β-arrestin, an accessory protein that induces tachyphylaxis, requiring increasing doses to elicit the same efficacy in subsequent doses. Clenbuterol activates the B2AR, a GPCR, thereby stimulating phosphorylation of downstream elements, binding β-arrestin, to regulate signaling pathways involved in muscle growth and decreased fat mass (recomp), as well as increased strength, sprint, power (performance). In the cases of both of these types of drugs, opioids/opiates & B2ARs like clenbuterol, the dose must be increased with subsequent uses in order to elicit comparable effects due to tachyphylaxis.

AR Regulation
AR, by contrast, is not a GPCR, and so is not associated with tachyphylaxis.

AR expression (the number/# of receptor proteins in our bodies) is regulated in several ways:

Broadly speaking, there are four (4) forms of regulation that control the number of receptors in the body. These are:

1. Transcription rate (i.e., up-regulate AR by increased transcriptional AR mRNA synthesis)
2. Translational efficiency (i.e., up-regulate AR by increased AR mRNA synthesis per ribosome)
3. Translational capacity (i.e., up-regulate AR by increased AR mRNA synthesis as a result of increased ribosomal biogenesis [↑ ribosome #])
4. Receptor turnover (i.e., up-regulate AR by decreased degradation/synthesis balance of AR mRNA)

To understand them, let’s quickly review the life-cycle of an individual AR.

? Transcription rate
There is a single gene in the DNA of each cell that codes for the AR. In the transcription process, the DNA code is copied to mRNA. The rate (frequency) of this process can be either increased (promoted) or decreased (repressed) depending on what other proteins are bound to the DNA at the time. Increase or decrease of this rate can be a form of regulation: the more AR mRNA is produced, all else being equal, the more ARs there will be. Bill Roberts.

✖ Translational efficiency
If efficiency is 100%, each mRNA will be used by a ribosome to produce an AR, which is a protein molecule. The process of making protein from the mRNA code is called translation. In practice efficiency will not be 100%. Changes in efficiency of translation can also be a form of regulation. Bill Roberts.

This, if it were a mechanism by which androgen regulated AR #, would be marked by mTOR activity (ie, myogenic markers, rpS6 or p70S6K increases in human skeletal muscle cells in vivo).

✓ Translational capacity
By increasing the # of ribosomes, the absolute # of AR produced by translation will increase. This is an important mechanism by which androgens ↑AR # in vivo.


The increase to AR # reflects, in part (r = 0.467), increased translational capacity, reflected by an increased muscle total RNA content (Δ μg RNA/mg muscle) that since ribosomal RNA comprises > 85% of cellular RNA, describes an increased ribosome # (suggesting that androgen/T stimulates ribosomal biogenesis):



? Receptor turnover
The final form of potential post-translational regulation is the rate of loss of ARs. If the cell produces x ARs per hour, and their half life is say 7.5 hours, then the number of ARs will be higher than if ARs are produced at that same rate but the half life is say only 3.3 hours. Thus, control of rate of turnover, or change in half-life, can be another means of regulation. Bill Roberts.

Conclusions
1. AR is up-regulated (AR # & density increased) by testosterone/androgen in human skeletal muscle cells in vivo.
2. This up-regulation is known to be a result of increased translational capacity by testosterone/androgen; and not translational efficiency a la mTOR.
3. Regulation of AR is not subject to desensitization; so, by corollary, there is no rationale to support cessation for resensitization.

 

[MastGod]

I cruise at 600mg

 

[KingOfSushi]

I was requested by PM to address the claim that androgen receptor (AR) "resensitization" is a rationale for discontinuing AAS, meaning that supraphysiologic androgen dose (AUC; nmol * h/L) induces tachyphylaxis (desensitization) analogous to opioid/opiate & Opioid Receptors (i.e., κ-, δ-, μ- OR) or clenbuterol & β₂Adrenergic Receptors (B2AR). Since I have some time and think that this is important, I will oblige.

Tachyphylaxis or desensitization is a feature of G-protein-coupled receptors (GPCRs) that AR is not. In the case of opioid/opiate drugs, the μ- OR is a GPCR subject to phosphorylation that recruits β-arrestin, an accessory protein that induces tachyphylaxis, requiring increasing doses to elicit the same efficacy in subsequent doses. Clenbuterol activates the B2AR, a GPCR, thereby stimulating phosphorylation of downstream elements, binding β-arrestin, to regulate signaling pathways involved in muscle growth and decreased fat mass (recomp), as well as increased strength, sprint, power (performance). In the cases of both of these types of drugs, opioids/opiates & B2ARs like clenbuterol, the dose must be increased with subsequent uses in order to elicit comparable effects due to tachyphylaxis.

AR Regulation
AR, by contrast, is not a GPCR, and so is not associated with tachyphylaxis.

AR expression (the number/# of receptor proteins in our bodies) is regulated in several ways:

Broadly speaking, there are four (4) forms of regulation that control the number of receptors in the body. These are:

1. Transcription rate (i.e., up-regulate AR by increased transcriptional AR mRNA synthesis)
2. Translational efficiency (i.e., up-regulate AR by increased AR mRNA synthesis per ribosome)
3. Translational capacity (i.e., up-regulate AR by increased AR mRNA synthesis as a result of increased ribosomal biogenesis [↑ ribosome #])
4. Receptor turnover (i.e., up-regulate AR by decreased degradation/synthesis balance of AR mRNA)

To understand them, let’s quickly review the life-cycle of an individual AR.

? Transcription rate
There is a single gene in the DNA of each cell that codes for the AR. In the transcription process, the DNA code is copied to mRNA. The rate (frequency) of this process can be either increased (promoted) or decreased (repressed) depending on what other proteins are bound to the DNA at the time. Increase or decrease of this rate can be a form of regulation: the more AR mRNA is produced, all else being equal, the more ARs there will be. Bill Roberts.

✖ Translational efficiency
If efficiency is 100%, each mRNA will be used by a ribosome to produce an AR, which is a protein molecule. The process of making protein from the mRNA code is called translation. In practice efficiency will not be 100%. Changes in efficiency of translation can also be a form of regulation. Bill Roberts.

This, if it were a mechanism by which androgen regulated AR #, would be marked by mTOR activity (ie, myogenic markers, rpS6 or p70S6K increases in human skeletal muscle cells in vivo).

✓ Translational capacity
By increasing the # of ribosomes, the absolute # of AR produced by translation will increase. This is an important mechanism by which androgens ↑AR # in vivo.

View attachment 181280
The increase to AR # reflects, in part (r = 0.467), increased translational capacity, reflected by an increased muscle total RNA content (Δ μg RNA/mg muscle) that since ribosomal RNA comprises > 85% of cellular RNA, describes an increased ribosome # (suggesting that androgen/T stimulates ribosomal biogenesis):

View attachment 181281View attachment 181282

? Receptor turnover
The final form of potential post-translational regulation is the rate of loss of ARs. If the cell produces x ARs per hour, and their half life is say 7.5 hours, then the number of ARs will be higher than if ARs are produced at that same rate but the half life is say only 3.3 hours. Thus, control of rate of turnover, or change in half-life, can be another means of regulation. Bill Roberts.

Conclusions
1. AR is up-regulated (AR # & density increased) by testosterone/androgen in human skeletal muscle cells in vivo.
2. This up-regulation is known to be a result of increased translational capacity by testosterone/androgen; and not translational efficiency a la mTOR.
3. Regulation of AR is not subject to desensitization; so, by corollary, there is no rationale to support cessation for resensitization.

in reference to our discussion @Biggerp73

I’m not who PMd type II, but he said it better than I could explain.

 

[marssel]

No idea.

i don’t even count my own.

Same here never once counted Calories

 

[Biggerp73]

in reference to our discussion @Biggerp73

I’m not who PMd type II, but he said it better than I could explain.

The only variable here isn't androgen receptor number or density

Type 2 might have some experience in the field of science but his logic is consistently poor

I remember when he was explaining his theory on GH dosing he just assumed the decisive variable was which method resulted in the highest peak of fats released in the blood

 

[prodaf]

My favorite cruise is with testo 400-500mg test & primo 200-300mg. And no AI.

 

[MastGod]

I cruise at 600mg a week

 

[Reno911]

I cruise at 600mg a week

Thanks for letting is know again. You've posted the same thing twice in the same thread.

 

[BigNJ]

2000mg test and EQ or primo mix - I'm just being honest

That's your cruise? Do you feel that if you cruised on less you might start losing weight?
That's quite the cruise.

 

[BigNJ]

I’d imagine this is more goal dependent than anything

This
You have to ask yourself what is the purpose of the cruise for you personally? Then decide on a dose that will accomplish your goal.

 

[Doitagain]

Thanks for letting is know again. You've posted the same thing twice in the same thread.

Surprising, isn't it?

 

[fit-n-all-physique]

200mg of test & stay on 5iu's of gh year round only on training days. Every now and then I will possibly add 100-200mg of masteron for the extra test boost & ai effect

 

[MastGod]

1500mg a week

 

[Reno911]

1500mg a week

Your only posts on this forum are in this thread saying you cruise at 600 and now you say you are cruising at 1500.

Can you just not post anymore please.

 

[MastGod]

Surprising, isn't it?

Real surprising

Your only posts on this forum are in this thread saying you cruise at 600 and now you say you are cruising at 1500.

Can you just not post anymore please.

i post what I want you don’t tell me what to do who you think you are

 

[Reno911]

Real surprising

i post what I want you don’t tell me what to do who you think you are

First of all. Please use at least semi decent punctuation.

Second. It's not looking like you're off to a good start here.

 

[Reno911]

Im from the streets we don’t use punctuation

"We"? Is this a joint account? Are you and your boyfriend on here together on the same account?

 

[juggy38]

Im from the streets we don’t use punctuation

Your father should of rolled over and shot you in a sock