- Joined
- Jun 24, 2012
- Messages
- 4,132
We know there is strong evidence that long term high dose AAS use often causes heart enlargement and left ventricular remodeling. That is along with the other sides such as high BP and horrible lipid profile. It is now starting to appear clear that anything beyond TRT dosages will have an impact on long term brain function and cognitive decline as the already hindered meathead specimen ages.
Supraphysiological doses of performance enhancing anabolic-androgenic steroids exert direct toxic effects on neuron-like cells
The androgens tested were dianabol and methyltestosterone (methyl test was worse, obviously). Conclusion: the toxicity results from binding to the AR and likely alters gene transcription to affect cell survival. They noted a short-term increase in neuritin expression as an adapative response to neuron injury.
They limited the study design to morphology and cell death utilizing the PC12 cell model. PC12s are a common and well characterized in vitro model for evaluation of chemical neurotoxicity from certain compounds/exposures.
We have known for some time that AAS has neurological sides, mostly related to long term reduction and disruption in visuospacial memory. Cognitive Deficits in Long-Term Anabolic-Androgenic Steroid Users
In addition, Trenbolone has been casually linked to a potential increased risk of Alzheimer's while, interestingly, trestolone possibly causes myelin regeneration. (Myelin facilitates electrical impulses along axons in the brain and spinal cord, transmitting neuronal signals to and from muscles, sensory organs and cognitive centers. People with Multiple Sclerosis (MS) have damaged myelin function.)
In sum, the dumb get dumber. Enjoy your body and youth while it lasts, boys!
Supraphysiological doses of performance enhancing anabolic-androgenic steroids exert direct toxic effects on neuron-like cells
The androgens tested were dianabol and methyltestosterone (methyl test was worse, obviously). Conclusion: the toxicity results from binding to the AR and likely alters gene transcription to affect cell survival. They noted a short-term increase in neuritin expression as an adapative response to neuron injury.
They limited the study design to morphology and cell death utilizing the PC12 cell model. PC12s are a common and well characterized in vitro model for evaluation of chemical neurotoxicity from certain compounds/exposures.
We have known for some time that AAS has neurological sides, mostly related to long term reduction and disruption in visuospacial memory. Cognitive Deficits in Long-Term Anabolic-Androgenic Steroid Users
In addition, Trenbolone has been casually linked to a potential increased risk of Alzheimer's while, interestingly, trestolone possibly causes myelin regeneration. (Myelin facilitates electrical impulses along axons in the brain and spinal cord, transmitting neuronal signals to and from muscles, sensory organs and cognitive centers. People with Multiple Sclerosis (MS) have damaged myelin function.)
In sum, the dumb get dumber. Enjoy your body and youth while it lasts, boys!
Last edited: