Just an FYI, exposed healthcare practitioners like myself have initiated Covid-19 prophylaxis. They've been doing it for a few weeks in harder hit countries with some purported success. Prophylactic studies have been initiated but are only about 1 week old. Some physicians are prophylactically dosing entire assisted living facilities/nursing homes, every resident. Current protocol we're following is the same as for malaria prophylaxis, hydroxychloroquine 400 mg po q wk on the same day every week x 10 weeks. You'll need 20 tabs. If you are not a healthcare worker or in a high risk group then prophylaxis is not for you. It may, in fact, seem irresponsible to post this but if you don't have fairly easy access it is unlikely you will be able to obtain it as restrictions are already being put in place. Unlike you complete fucking moronic assholes who hoard all the toilet paper while you congregate in mass at Costco and spread disease. But there are healthcare workers here and those at high risk who may want to consider. While Tamiflu is not particularly effective as a flu treatment, it is very effective for prophylaxis, 90%. We also see that hydroxychloroquine may be more effective as prophylaxis for malaria than for treatment.
https://clinicaltrials.gov/ct2/show/NCT04303507 This is the wrong drug, chloroquine, less effective more sides.
Current treatment for confirmed or suspected cases is hydroxychloroquine 400 mg po q12h on day 1, 200 mg po bid on days 2-5 plus a traditional Z-Pak. 95% cleared virus by day 6 with this protocol which was extensively used in South Korea, with and without azithromycin. South Korea has managed only 98 deaths despite having the fastest spread outside of Wuhan at one point. Out of 8,692 confirmed cases which places the mortality rate precisely in line with the common flu at .01%.
Like Tamiflu and Xofluza it is important that therapy is initiated within 24-48 hrs of symptom onset if treating, for maximal efficacy. Xofluza and Tamifu are both basically useless if started after 48h. Initiation of therapy with symptoms is paramount in acute anti-viral tx.
This perhaps the best treatment guidance document I have seen so far and will be updated as new information arises.
Stay safe!
Rex.
https://clinicaltrials.gov/ct2/show/NCT04303507 This is the wrong drug, chloroquine, less effective more sides.
COVID-19 Clinical Trial Launches at University of Minnesota
The University of Minnesota today is launching a clinical trial on a post-exposure treatment for coronavirus COVID-19 disease.
med.umn.edu
Current treatment for confirmed or suspected cases is hydroxychloroquine 400 mg po q12h on day 1, 200 mg po bid on days 2-5 plus a traditional Z-Pak. 95% cleared virus by day 6 with this protocol which was extensively used in South Korea, with and without azithromycin. South Korea has managed only 98 deaths despite having the fastest spread outside of Wuhan at one point. Out of 8,692 confirmed cases which places the mortality rate precisely in line with the common flu at .01%.
Like Tamiflu and Xofluza it is important that therapy is initiated within 24-48 hrs of symptom onset if treating, for maximal efficacy. Xofluza and Tamifu are both basically useless if started after 48h. Initiation of therapy with symptoms is paramount in acute anti-viral tx.
This perhaps the best treatment guidance document I have seen so far and will be updated as new information arises.
Stay safe!
Rex.