• All new members please introduce your self here and welcome to the board:
    http://www.professionalmuscle.com/forums/showthread.php?t=259
Buy Needles And Syringes With No Prescription
M4B Store Banner
ddd
Riptropin Store banner
Generation X Bodybuilding Forum
Buy Needles And Syringes With No Prescription
Buy Needles And Syringes With No Prescription
Mysupps Store Banner
IP Gear Store Banner
Anabolic Hormones Store Banner
Ganabol Store Banner
Spend $100 and get bonus needles free at sterile syringes
Professional Muscle Store open now
LandmarkChem Email Banner
Medtech Store Banner
Bruce Labs Store banner
qtropin
Professional Muscle Store open now
over 5000 supplements on sale at professional muscle store
Buy Needles And Syringes With No Prescription
over 5000 supplements on sale at professional muscle store
Buy Needles And Syringes With No Prescription
over 5000 supplements on sale at professional muscle store
over 5000 supplements on sale at professional muscle store
over 5000 supplements on sale at professional muscle store
over 5000 supplements on sale at professional muscle store
over 5000 supplements on sale at professional muscle store
over 5000 supplements on sale at professional muscle store
over 5000 supplements on sale at professional muscle store
over 5000 supplements on sale at professional muscle store

ALA??

F

freefaller21

Guest
What do you guys think of ALA? I just picked some up today. How much should I take on a daily basis? Does it really work.
 

Mr_Magoo

New member
Kilo Klub Member
Joined
Jun 5, 2002
Messages
1,828
for a good source pm me, anyways it is good, but the r-ala version is much better and more potent
 

ken69dahl

New member
Registered
Joined
Sep 23, 2002
Messages
260
1000-1500mg ed
 
F

freefaller21

Guest
Wow, 1000-1500mg a day? with the stuff I got each capsule is 100mg. And the store I got it from only recommends 200mg ED, it wouldn't be harmful at that high a dose would it? Please excuse the stupid questions, I'm a newbie.:)
 

mike man

FOUNDING Member
Registered
Joined
Jun 5, 2002
Messages
907
What about

Taking insulin while taking ALA? would this be a no-no since it is said that ALA raises your insulin sensitivity?
 

Mr_Magoo

New member
Kilo Klub Member
Joined
Jun 5, 2002
Messages
1,828
which means ull need smaller amounts of slin to get the same anabolic effect
 

raybravo

New member
Registered
Joined
Dec 26, 2002
Messages
338
Mr_Magoo said:
which means ull need smaller amounts of slin to get the same anabolic effect
i think metformin would be so much more benefitial compared to ala to improve insulin sensitivity .
although so many people like ala , it seems to inhibit glycogen synthesis quite a bit , making it not a very good thing to add to one's supplement regimen .

J Nutr 2002 Oct;132(10):3001-6 Related Articles, Links


Alpha-lipoic acid inhibits glycogen synthesis in rat soleus muscle via its oxidative activity and the uncoupling of mitochondria.

Dicter N, Madar Z, Tirosh O.

Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot 76100, Israel.

alpha-Lipoic acid (LA) is currently being investigated as a glucose-lowering agent for diabetes control; it is also considered a powerful dietary antioxidant. The objective of this study was to investigate the fate of glucose in isolated rat muscles incubated with LA and determine its effects on intramuscular redox status. Rat soleus muscles were incubated for up to 60 min with 2.4 mmol/L LA in the presence or absence of insulin. Intramuscular concentrations of LA were evaluated (uptake and reduction), and glycogen synthesis, glucose oxidation, intramuscular reactive oxygen species (ROS) production and mitochondrial membrane potential investigated. Insulin enhanced glycogen synthesis, whereas LA decreased rates by >50%. LA elevated ROS production and in combination with t-butylhydroperoxide, an oxidant, additively inhibited glycogen synthesis rates by 80%. Insulin acted as an antioxidant and attenuated ROS production by 30%. LA uncoupled the mitochondria and accelerated glucose oxidation 1.5-fold relative to the control. The glycogen synthesis pathway was found to be dependent on mitochondrial function because treatment with mitochondrial inhibitors eliminated the majority of glycogen synthesis. These data show that in this model, LA acts as a mild prooxidant, causing mitochondrial uncoupling and inhibition of glycogen synthesis. It appears that LA regulates glucose metabolism in the muscle differently than insulin.
 

Staff online

Forum statistics

Total page views
501,822,029
Threads
123,343
Messages
2,347,530
Members
155,054
Latest member
Diamondnine
Top