Anyone ever use a Methylprednisolone Pak

[KillerStack]

medrol comes as a pack designed to take over 6 days in a taper. It`s not an ibuprofen you take for one day. It is NEVER for ongoing use because of side effects including destroying your adrenal glands.

That's what I got for a throat issue. But I'm curious if there are serious consequences to take it for just one day, especially if that is enough to calm some issue down, like what Massive G does.

Remember when Trump got covid and was especially animated the press screamed "steroid mania." I think he got one dose, and maybe it did affect his mood, I don't know. Several people say you are flying high the first day, but I read corticosteroids cause psychosis in relatively many people.

 

[KillerStack]

Obesity and Prednisone: Weekly Dose 'Strikingly Different' Outcomes vs. Daily - Research Horizons

scienceblog.cincinnatichildrens.org

I am using prednisone to help with extreme inflammation and associated joint and muscle pain every 2 weeks. Dosed at around 11 pm delayed release. And it helps me tremendously. If using regular prednisone it's taken at 2 am.

I should have put this in my first reply to you but I was too slow. How did you come up with this dosing schedule?

 

[MAD_SCIENTIST]

@hulkboy, be careful with any chiropractor. If you have legitimate damage to your disc in between your L5 & S1 it could be aggravated further by a chiro.

I used to visit a chiro often prior to severely injuring my lower back. It helped at the time, but now I was advised by my orthopedic & numerologist to NEVER visit a chiropractor anymore. Just keep that in mind.

Cage

Hi Cage... interesting.
You said you also use a numerologist, has your numerologist guided you on other areas of your life?

MS

 

[hogan87]

That's what I got for a throat issue. But I'm curious if there are serious consequences to take it for just one day, especially if that is enough to calm some issue down, like what Massive G does.

Remember when Trump got covid and was especially animated the press screamed "steroid mania." I think he got one dose, and maybe it did affect his mood, I don't know. Several people say you are flying high the first day, but I read corticosteroids cause psychosis in relatively many people.

It depends on what your throat issue is. You have a bacterial or viral infections going on? Don`t take a medrol pack. I (and every dr) totally disagree with taking 1 prednisone every 2 weeks or randomly. That`s not how its prescribed. It is not FIXING pain but masking at best and destroying adrenal function which will lead to more fatigue and pain if its used long term

 

[Massive G]

Wow...Go check out my thread "What a month".... Prednisone would have fucked my fiance up big time if she'd stay on it.... different circumstances tho'...

First off hope you and your fiance are doing well. And yes it can be one of the nastiest drugs out there especially doctors that chronically dose up people to cover any and all anti inflammatory conditions.

As I stated I take it once a week on Fridays in the middle of the night when your body is most receptive to it and releasing its own while you sleep.

Whenever I have been prescribed a pack I only take a few days of it instead of finishing out the dosing up and down.
I have seen chronically overprescribed family members turn into lifeless emotional zombies and it's terrible.

 

[Bio]

@hulkboy It sounds like it's a dose pack by your description, which is 5 days or so if I remember correctly. Not a big deal, as it's very short term. Long term, it has a lot of bad side effects, but in your case it should be helpful. Here's the catch, it will most likely get the inflammation to subside but if there's an underlying spine issue, you could easily trigger it again! Be careful with what movements you do. Hopefully this is something minor and short term!!

 

[Massive G]

I should have put this in my first reply to you but I was too slow. How did you come up with this dosing schedule?

Hey..I actually got the idea from gotgame who posted here at one time and other boards. He is a doc or PA can't remember. He wrote about how he used cortisol infrequently to help control the extreme inflammation. I only use it when I am destroyed mentally and physically from work and training. Which is Friday night for me which happens to be leg day so I can get 2 days of recovery in on the weekend vs hobbling around work.
I successfully used it during lockdowns to treat my low back which kept locking up since all I could do was 10 to 12 sets of free weight squats and front squats. I have used regular prednisone as well which I take around 2 am when waking up. I am not recommending anyone do this but it helps me navigate through aging and still bombing and blitzing heavy ass free weights.

 

[pimpman]

Man they gave me that at the er about a few months ago for some inflammation and half way through the pack my penis was peeling all over like a sunburn . Freaked out and was like wtf going on. I called my primary and she said get of it it’s a side effect from it.it was causing thrush. I got off she sent me some cream and it all went away in about a week. Never again I will touch that med

 

[cage99]

Hi Cage... interesting.
You said you also use a numerologist, has your numerologist guided you on other areas of your life?

MS

Apple gots me on that one… “neurologist”… Either that or my fat ass fingers got me… Probably the latter…

Cage

 

[alfresco]

There is nothing wrong with taking it. If I was level 9-10/10 pain I would take it. Like not being able to walk agonizing pain. But if you are flared for a couple days and its not too bad then do ibuprofen 800mg 3x/day first. I would ice the area if it were me.

Yes

And also it takes a while to kick in, tapering up and tapering down when used correctly with the dosage that fits your circumstances. Not a med in my opinion to quickly go on and off of.

Like others have said, tread carefully. It is literally a miracle drug when used correctly but it has its issues. Be aware.

This was my experience, and my experience only.

 

[bbxtreme]

That's what I got for a throat issue. But I'm curious if there are serious consequences to take it for just one day, especially if that is enough to calm some issue down, like what Massive G does.

Remember when Trump got covid and was especially animated the press screamed "steroid mania." I think he got one dose, and maybe it did affect his mood, I don't know. Several people say you are flying high the first day, but I read corticosteroids cause psychosis in relatively many people.

What you are referencing is generally reserved for serious immune cases or autoimmune disorders in the hospital. They will administer an IV of Predisone to try and ramp up the immune system to clear out something or inflammation.

In health and medicine I always use the expression “what goes up must come down.” This same rule can be applied to any biological or biochemical change we make at extremes in most cases.

Using Predisone to ramp the body’s immune system this hard will throw off mineral balance and the HPA axis (just to name a few). Many feel great while on it and then fatigued once off it as the body has to level back out.

It should be reserved for extreme or indicated cases IMO. There are cases such as my father where it can be used. He has multiple autoimmune disorders and immunosuppressants do not work with him at all. So he is now years in and dependent on titrating Predisone dosages to manage it. You can tell how much he’s on by how he’s acting. He acts like it’s Halotestin some days. Is it ideal? No, but we have to pick the best path forward to manage it while maintaining his quality of life.

But IMO Predisone should be a last resort drug used as nothing good comes from it long term and should be avoided for better alternatives in acute cases.

 

[LK3]

theres probably much better ways to deal with the pain.
corticoids are loaded with weird side effects. they do work often quite well at fist but they come with sides which can get compounded over time.
weird head stuff too in terms of side effects and emotions.
my first choice for pain would be opiates.

 

[KillerStack]

It depends on what your throat issue is. You have a bacterial or viral infections going on? Don`t take a medrol pack. I (and every dr) totally disagree with taking 1 prednisone every 2 weeks or randomly. That`s not how its prescribed. It is not FIXING pain but masking at best and destroying adrenal function which will lead to more fatigue and pain if its used long term

I mean I got it prescribed for a severely swollen throat years ago and a "side-effect" was immediate lifting of any joint pain. I wasn't injured but I remember descending into a squat with the bar warming up and thinking, wth is this, feels amazing. I wrote earlier that I KNOW it's not fixing anything and I know it's dangerous. At the same time I know it's an amazing PED in certain circumstances, like in cycling, they all have scripts for cortisone cream for saddle sores, obviously wanting any tiny extra cort they can get. Also seen mention of it for powerlifting comps but never any exact plan on exactly what or when to take.

Hey..I actually got the idea from gotgame who posted here at one time and other boards. He is a doc or PA can't remember. He wrote about how he used cortisol infrequently to help control the extreme inflammation. I only use it when I am destroyed mentally and physically from work and training. Which is Friday night for me which happens to be leg day so I can get 2 days of recovery in on the weekend vs hobbling around work.
I successfully used it during lockdowns to treat my low back which kept locking up since all I could do was 10 to 12 sets of free weight squats and front squats. I have used regular prednisone as well which I take around 2 am when waking up. I am not recommending anyone do this but it helps me navigate through aging and still bombing and blitzing heavy ass free weights.

Thanks MG. Everyone says it's a bad idea but I still would like to know if a single admin of one tablet has serious acute or chronic risks lol.

A friend threw me a bottle of betamethasone without me asking but I haven't looked at its relative potency and so on.

What you are referencing is generally reserved for serious immune cases or autoimmune disorders in the hospital. They will administer an IV of Predisone to try and ramp up the immune system to clear out something or inflammation.

In health and medicine I always use the expression “what goes up must come down.” This same rule can be applied to any biological or biochemical change we make at extremes in most cases.

Using Predisone to ramp the body’s immune system this hard will throw off mineral balance and the HPA axis (just to name a few). Many feel great while on it and then fatigued once off it as the body has to level back out.

It should be reserved for extreme or indicated cases IMO. There are cases such as my father where it can be used. He has multiple autoimmune disorders and immunosuppressants do not work with him at all. So he is now years in and dependent on titrating Predisone dosages to manage it. You can tell how much he’s on by how he’s acting. He acts like it’s Halotestin some days. Is it ideal? No, but we have to pick the best path forward to manage it while maintaining his quality of life.

But IMO Predisone should be a last resort drug used as nothing good comes from it long term and should be avoided for better alternatives in acute cases.

Thanks. It will lower the immune system right, so you would be potentially be susceptible to a serious infection right? I'm just trying to put it into perspective, if doing it once might in some unfortunate circumstance fuck up you adrenals for life or similar. Or if a single admin could lower immunity for a long while. Like I said, Trump got the one corticosteroid dose, I presume to nip any incipient lung inflammation in the bud? But there's probably a catch because it was not done routinely. I don't know if Trump was in serious trouble, some think he was, but they did give him the steroid among many other things and treating the Pres is serious business. I was personally interested in what they did with him because I was twice on a ventilator and would rather try a crazy steroid dose if possible before going under again. Not that I would do it on my own, and they probably wouldn't give it anyway. Both times it was, arrive at the ICU, one phone call, no discussion about anything, and I was out within what seemed like 5 minutes after arriving. Helpless feeling.

 

[Hyperemia]

I would be very cautious about using glucocorticoids long term because of their effect on blood glucose. I was recently on prednisone and my blood sugar went into the stratosphere almost immediately. After searching for a link between prednisone and high blood sugar, it turns out that this is an extremely common issue and it makes sense since it’s basically cortisol.

 

[bbxtreme]

I mean I got it prescribed for a severely swollen throat years ago and a "side-effect" was immediate lifting of any joint pain. I wasn't injured but I remember descending into a squat with the bar warming up and thinking, wth is this, feels amazing. I wrote earlier that I KNOW it's not fixing anything and I know it's dangerous. At the same time I know it's an amazing PED in certain circumstances, like in cycling, they all have scripts for cortisone cream for saddle sores, obviously wanting any tiny extra cort they can get. Also seen mention of it for powerlifting comps but never any exact plan on exactly what or when to take.



Thanks MG. Everyone says it's a bad idea but I still would like to know if a single admin of one tablet has serious acute or chronic risks lol.

A friend threw me a bottle of betamethasone without me asking but I haven't looked at its relative potency and so on.


Thanks. It will lower the immune system right, so you would be potentially be susceptible to a serious infection right? I'm just trying to put it into perspective, if doing it once might in some unfortunate circumstance fuck up you adrenals for life or similar. Or if a single admin could lower immunity for a long while. Like I said, Trump got the one corticosteroid dose, I presume to nip any incipient lung inflammation in the bud? But there's probably a catch because it was not done routinely. I don't know if Trump was in serious trouble, some think he was, but they did give him the steroid among many other things and treating the Pres is serious business. I was personally interested in what they did with him because I was twice on a ventilator and would rather try a crazy steroid dose if possible before going under again. Not that I would do it on my own, and they probably wouldn't give it anyway. Both times it was, arrive at the ICU, one phone call, no discussion about anything, and I was out within what seemed like 5 minutes after arriving. Helpless feeling.

Predisone IMO is best indicated for short term acute cases of immune disorders or inflammation. The shorter the duration and the least amount you can use the better.

The body will adapt to it over time so the less you have to use it the better. Some people think “just once” at 10mg and end up years later taking 20-40mg a day just to function.

It’s no different than using gear- just know the risk vs rewards. One day on it won’t hurt anything likely in the long run, but using it when not truly indicated won’t do you any favors either.

 

[Jefe]

I just started today for rotator cuff surgery. I do have S1/L5 degeneration, beginning stage.

I’ll report back.

Only taking it cuz my other shoulder has tendinitis from compensating for the bad one.

Yes I know it’s awful but I’ve put worse things in me

 

[LK3]

I mean I got it prescribed for a severely swollen throat years ago and a "side-effect" was immediate lifting of any joint pain. I wasn't injured but I remember descending into a squat with the bar warming up and thinking, wth is this, feels amazing. I wrote earlier that I KNOW it's not fixing anything and I know it's dangerous. At the same time I know it's an amazing PED in certain circumstances, like in cycling, they all have scripts for cortisone cream for saddle sores, obviously wanting any tiny extra cort they can get. Also seen mention of it for powerlifting comps but never any exact plan on exactly what or when to take.



Thanks MG. Everyone says it's a bad idea but I still would like to know if a single admin of one tablet has serious acute or chronic risks lol.

A friend threw me a bottle of betamethasone without me asking but I haven't looked at its relative potency and so on.


Thanks. It will lower the immune system right, so you would be potentially be susceptible to a serious infection right? I'm just trying to put it into perspective, if doing it once might in some unfortunate circumstance fuck up you adrenals for life or similar. Or if a single admin could lower immunity for a long while. Like I said, Trump got the one corticosteroid dose, I presume to nip any incipient lung inflammation in the bud? But there's probably a catch because it was not done routinely. I don't know if Trump was in serious trouble, some think he was, but they did give him the steroid among many other things and treating the Pres is serious business. I was personally interested in what they did with him because I was twice on a ventilator and would rather try a crazy steroid dose if possible before going under again. Not that I would do it on my own, and they probably wouldn't give it anyway. Both times it was, arrive at the ICU, one phone call, no discussion about anything, and I was out within what seemed like 5 minutes after arriving. Helpless feeling.

one dose probably isnt going to hurt you.

there was some talk years ago on animals site of using corticoids to extend the effectiveness of your cycle as aas lower cortistol to which your body may respond by producing more so taking small or strategic amounts of corticoides may help to knock back that natural increase.

i cant say weather it worked or not.
animals back ground was cycling.

 

[KillerStack]

one dose probably isnt going to hurt you.

there was some talk years ago on animals site of using corticoids to extend the effectiveness of your cycle as aas lower cortistol to which your body may respond by producing more so taking small or strategic amounts of corticoides may help to knock back that natural increase.

i cant say weather it worked or not.
animals back ground was cycling.

Ah yes, now I remember I read that on Animal's site, it was with hydrocortisone and he had a dosage which he or others said would not shut you down, according to research.

I don't understand much about cortisol but the Russians had a test to see if someone was using too many anabolics or taking extra on the side. They gave a dose of dbol at night and tested cortisol in the morning. It was supposed to go up if you aren't desensitized to anabolics.
You sure Animal didn't say there might actually be a lack of cortisol on long cycles? There was talk about how tren etc antagonized cortisol and that was bad long term so you added some to extend the cycle. Even Duchaine said the cort antagonism was probably bad. That's how I remember it but may be completely wrong lol.

 

[LK3]

Ah yes, now I remember I read that on Animal's site, it was with hydrocortisone and he had a dosage which he or others said would not shut you down, according to research.

I don't understand much about cortisol but the Russians had a test to see if someone was using too many anabolics or taking extra on the side. They gave a dose of dbol at night and tested cortisol in the morning. It was supposed to go up if you aren't desensitized to anabolics.
You sure Animal didn't say there might actually be a lack of cortisol on long cycles? There was talk about how tren etc antagonized cortisol and that was bad long term so you added some to extend the cycle. Even Duchaine said the cort antagonism was probably bad. That's how I remember it but may be completely wrong lol.

seems like kind of mixed info out there but i think the idea was that aas are not stopping cortistol production so much as out competing at receptor cites. so as you get longer into a cycle you actually have higher circulating cortistol levels but blunted effect. this may contribute to mental side effects.

the mental stuff is something i notice. i would often get a little too wacky towards the end of of a long run. after some time oi thought it might be from this.

i remember the russian studies but not well enough to get specific. i remember the aas test and that there were 4 different response levels but not much about how it was done.

 

[Jefe]

Side effects on day 2 or 3 = extreme irritability. Pain in tendonitis shoulder is much more tolerable.