Anyone from Germany on the board, or heard of this stuff before

[N_iraq]

had some people tell me about a supplement they used in Germany called X-112 Antiadipositum

 

[dragonfire101]

Contains Cathinone,Nikethamide and caffeine. Sounds like a super stimulant with some euphoric properties. See Article below after the descriptions of Cathinone an Nikethamide.


Cathinone is an alkaloid that has been discovered some fifteen years ago in the leaves of the khat bush. This plant grows in East Africa and in southern Arabia, and the inhabitants of these regions frequently chew khat because of its stimulating properties. Cathinone, which is S(-)-alpha-aminopropiophenone, was soon found to have a pharmacological profile closely resembling that of amphetamine; indeed, in a wide variety of in vitro and in vivo experiments it was demonstrated that cathinone shares the action of amphetamine on CNS as well as its sympathomimetic effects; thus, for example, drug-conditioned animals will not distinguish between cathinone and amphetamine. These various observations were confirmed by a clinical experiment showing that cathinone also in humans produces amphetamine-like objective and subjective effects. Finally, it was demonstrated that cathinone operates through the same mechanism as amphetamine, i.e. it acts by releasing catecholamines from presynaptic storage sites. Thus, much experimental evidence indicates that cathinone is the main
psychoactive constituent of the khat leaf and that, in fact, this alkaloid is a natural amphetamine.


Nikethamide: A CENTRAL NERVOUS SYSTEM STIMULANT. It was formerly used in the treatment of barbiturate overdose but is now considered to be of no value for such purposes and may be dangerous.



1: Pharmacol Biochem Behav. 1989 Jun;33(2):299-301. Related Articles, Links


Potentiation of cathinone by caffeine and nikethamide.

Schechter MD.

Department of Pharmacology, Northeastern Ohio University, College of Medicine, Rootstown 44272.

The drug discrimination paradigm was employed to evaluate the effect of coadministration of both caffeine and nikethamide upon the discrimination of a low dose of cathinone. In rats trained to discriminate between 0.8 mg/kg l-cathinone and its vehicle in a two-lever food-motivated operant task, 0.2 mg/kg cathinone produced 29.2% of responses on the cathinone-appropriate lever. This lever was chosen in 0 and 50% of trials with 25 mg/kg nikethamide and 20 mg/kg caffeine, respectively. Coadministration of caffeine, nikethamide, or caffeine plus nikethamide with low-dose cathinone produced strong cathinone-like discriminative performance. This potentiattion of cathinone by caffeine and nikethamide is reflective of noncontrolled drugs of abuse containing similar combinations especially for that of antiadipositum X-112, a drug containing all three agents and widely abused in Europe.
PMID: 2813469 [PubMed - indexed for MEDLINE]

 

[N_iraq]

Damn Dragonfire101 thats was a mouthful

Contains Cathinone,Nikethamide and caffeine. Sounds like a super stimulant with some euphoric properties. See Article below after the descriptions of Cathinone an Nikethamide.


Cathinone is an alkaloid that has been discovered some fifteen years ago in the leaves of the khat bush. This plant grows in East Africa and in southern Arabia, and the inhabitants of these regions frequently chew khat because of its stimulating properties. Cathinone, which is S(-)-alpha-aminopropiophenone, was soon found to have a pharmacological profile closely resembling that of amphetamine; indeed, in a wide variety of in vitro and in vivo experiments it was demonstrated that cathinone shares the action of amphetamine on CNS as well as its sympathomimetic effects; thus, for example, drug-conditioned animals will not distinguish between cathinone and amphetamine. These various observations were confirmed by a clinical experiment showing that cathinone also in humans produces amphetamine-like objective and subjective effects. Finally, it was demonstrated that cathinone operates through the same mechanism as amphetamine, i.e. it acts by releasing catecholamines from presynaptic storage sites. Thus, much experimental evidence indicates that cathinone is the main
psychoactive constituent of the khat leaf and that, in fact, this alkaloid is a natural amphetamine.


Nikethamide: A CENTRAL NERVOUS SYSTEM STIMULANT. It was formerly used in the treatment of barbiturate overdose but is now considered to be of no value for such purposes and may be dangerous.



1: Pharmacol Biochem Behav. 1989 Jun;33(2):299-301. Related Articles, Links


Potentiation of cathinone by caffeine and nikethamide.

Schechter MD.

Department of Pharmacology, Northeastern Ohio University, College of Medicine, Rootstown 44272.

The drug discrimination paradigm was employed to evaluate the effect of coadministration of both caffeine and nikethamide upon the discrimination of a low dose of cathinone. In rats trained to discriminate between 0.8 mg/kg l-cathinone and its vehicle in a two-lever food-motivated operant task, 0.2 mg/kg cathinone produced 29.2% of responses on the cathinone-appropriate lever. This lever was chosen in 0 and 50% of trials with 25 mg/kg nikethamide and 20 mg/kg caffeine, respectively. Coadministration of caffeine, nikethamide, or caffeine plus nikethamide with low-dose cathinone produced strong cathinone-like discriminative performance. This potentiattion of cathinone by caffeine and nikethamide is reflective of noncontrolled drugs of abuse containing similar combinations especially for that of antiadipositum X-112, a drug containing all three agents and widely abused in Europe.
PMID: 2813469 [PubMed - indexed for MEDLINE]

Thanks for the info, do u know if anyone has tried it before or even if its on the market? the guys told me that it really was a super fat burner and energy boost.

 

[dragonfire101]

Dont know anyone who ever used it Im in the U.S. its been around awhile from what i read. Its pretty much going to be like amphetamines. So it will burn fat give you energey and suppress appetite. From reading the study on it it doesn't sound to healthy to use.