Incredibly tragic. RIP. Sorry luki.
For you young guys or those that know it's bad but don't know why, cocaine is a potent vasoconstrictor!
Be safe and educate yourself!
In addition, cocaine stimulates the release of endothelin-1, a potent vasoconstrictor, from endothelial cells
14 and inhibits nitric oxide production, the principal vasodilator produced by endothelial cells.
15 Cocaine promotes thrombosis by activating platelets,
16,
17 increasing platelet aggregation,
16,
18 increasing platelet α-granule release,
16,
19 increasing plasminogen activator inhibitor activity,
20 and increasing fibrinogen and von Willebrand factor levels.
21 Calcification
22 and aneurysms
23 occur frequently in the coronary arteries of cocaine users. MI in non–cocaine-using patients with traditional risk factors typically results from plaque fissure or rupture with plaque hemorrhage, which precipitates thrombosis. In contrast, MI in cocaine-using patients involves intracoronary thrombosis superimposed on smooth muscle cell–rich fibrous plaques without plaque rupture or hemorrhage.
24 Moreover, plaques in cocaine-using patients feature medial or intimal inflammation (primarily lymphocytes and plasma cells) and adventitial mast cells, whereas non–cocaine-using patients did not have arterial wall inflammation of this morphology.
24
https://www.ahajournals.org/doi/full/10.1161/circulationaha.110.940569