In the short term no, in the long term yes. The acute effects of taking a DHT derivative, or anything else, for a little while can be very different from the chronic effects of long-term use or abuse. And of course the dose makes the poison, as with any drug, taking small or reasonable doses can be very different than shotgunning huge amounts for a long time.
Like most things, the best answer is "well, it depends..."
Personally, I have found that taking reasonable doses (no more than 50mg Proviron per day, or an equivalent amount of Masteron per week) only helps things in that regard. YMMV.
Could definitely cause prostate issues , and like everything some people are way more sensitive than others.
I like adding in a little mast to each of my try shots (50mg mast with 125mg test) , I feel much better and don't see any negative sides. With blood work it keeps my estrogen on the low side of normal. I have a prostate exam every year and everything come back normal.