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- Feb 26, 2016
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I know this an old thread but im actually starting HGH and wanted to see how to combat insulin sensitivity. Whats the best way and how much to take metformin? Is 500 enough for lets say 4iu oh GH per day? Can nightime only be ok for the metformin?
I wouldn't touch metformin until you know you need it. It may or may not have positive effects on muscle growth/body comp, but it can have side effects as with any potent medication.
Generally, steady state cardio / being lean / being muscular will all greatly enhance insulin sensitivity.
Taking the GH in the AM will reduce insulin sensitivity since you will be spiking insulin every time you eat during the day more than if you took it in the PM. Taking it three times per week, especially at night will further mitigate insulin sensitivity.
This isn't an issue for most guys/girls. Most won't have any issues up to 5 IU SQ AM daily, but if you are sedentary or have genetic predisposition to diabetes/hyperglycemia, you might see some issues. I have elevated fasting BG the first month or so on 4-5 IU on my first run which completely resolved itself without doing anything. I wasn't even doing that much cardio back then if any at the time.
Finally, some insulin resistance is an EXPECTED outcome of using HGH even at medical dosages sometimes. It does not always mean it's dangerous to your health or will increase your risk of diabetes. The insulin resistance might actually be one of the mechanism in the improvement in body composition. (less easy for the body to store extra calories/energy as fat).