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not sure if these studies have been discussed, but its new to me and i find it intersting how different derivatives cause different monoamine activity....theese are all short term though i wonder how much it can chane in the loooong run.
Action of androgenic steroids on brain neurotransmitters in rats.Vermes I, Várszegi M, Tóth EK, Telegdy G.
The effects of androgenic steroids on the dopamine (DA), noradrenaline (NA) and 5-hydroxytryptamine (5-HT) contents of different brain regions have been studied in order to elucidate the possible involvement of neurotransmitters in the negative feedback action of androgens. Administration of testosterone propionate (TP); (100 micrograms/kg or 5 mg/kg, i.p.) increased plasma testosterones, which reached a maximum at about 30 min following injections. TP (100 micrograms/kg) decreased the DA level in the hypothalamus to a minimum after 30 min and returned to normal level after 120 min. There was no effect in the amygdala, striatum and mesencephalon. Subsequent to 5 mg/kg i.p. TP administration, the minimum in the DA level was observed between 90 and 120 min in the hypothalamus, and after 120 min in the amygdala, but the treatment was without effect in the striatum and mesencephalon. Both doses of TP were ineffective as regards for in altering NA and 5-HT levels in the brain areas studied. In a dose of 5 mg/kg, androgens of different activities, such as norandrostenolone, dihydrostestosterone and androstenedione, decreased the DA contents of the hypothalamus and amygdala regions, but pregnenolone was ineffective. None of the androgens affected the NA and 5-HT levels in the brain areas studied. The data suggest that some of the actions of androgens are mediated via a dopaminergic mechanism in which not only the hypothalamus but also the amygdala is involved.
PMID: 37455 [PubMed - indexed for MEDLINE]
Psychological and serum homovanillic acid changes in men administered androgenic steroids.Hannan CJ Jr, Friedl KE, Zold A, Kettler TM, Plymate SR.
Department of Clinical Investigation, Madigan Army Medical Center, Tacoma, Washington.
We report a difference in the response of serum homovanillic acid (HVA) and in the performance of some psychological tasks before and after the administration of testosterone enanthate (TE, 100 or 300 mg/wk) or nandrolone decanoate (ND, 100 or 300 mg/wk) for 6 wk to healthy men. Serum HVA was significantly increased in both the low- and high-dose ND groups, from 8.4 +/- 1.0 and 8.7 +/- 0.5 pmol/ml (mean +/- SE) to 11.6 +/- 1.7 and 10.7 +/- 1.1 pmol/ml respectively. No significant changes in HVA were observed for the groups administered TE, nor in 5-HIAA for any of the groups. The influence of ND on the dopaminergic system, which is reflected in increased serum HVA, appears to be independent from the psychological effects which were produced by both androgens. The only change in psychomotor test performance was an improvement in the first trial of a pegboard task. All subjects except those receiving ND (100 mg/wk) were significantly more optimistic in the prediction of their own performance for all nondominant hand tasks (pegboard and finger tapping). The "hostility" and "resentment and aggression" subscales of the MMPI increased significantly in all groups, more so in the high-dose groups.
PMID: 1745700 [PubMed - indexed for MEDLINE]
Increased dopaminergic and 5-hydroxytryptaminergic activities in male rat brain following long-term treatment with anabolic androgenic steroids.Thiblin I, Finn A, Ross SB, Stenfors C.
Department of Forensic Medicine, Karolinska Institute, Stockholm, Sweden.
1. The effects of treating groups of rats with four different anabolic androgenic steroids (AAS) (testosterone, nandrolone, methandrostenolone, and oxymetholone) on 5-hydroxytryptamine (5-HT) and dopamine (DA) neurones in different brain regions were examined. The AAS was injected six times with 1 week's interval and the rats were sacrificed 2 days after the final injection. 5-HT and its metabolite 5-hydroxyindoleacetic acid (5-HIAA), DA and its metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) were measured. The effect on DA and 5-HT synthesis rate was analysed as the accumulation of 3,4-dihydroxyphenyl-alanine (DOPA) and 5-hydroxytryptophan (5-HTP), respectively, after inhibition of the amino acid decarboxylase with NSD-1015 (3-hydroxy-benzylhydrazine dihydrochloride). Additionally, the monoamine oxidase (MAO) activity was analysed in the hypothalamus. 2. The DOPAC + HVA/DA ratio was increased in the striatum in all treatment groups. However, the synthesis rate of DA was significantly increased only in the methandrostenolone treated group. 3. The 5-HIAA/5-HT ratio was increased in all treatment groups in the hippocampus, in the frontal cortex in the methandrostenolone-treated animals and in the hypothalamus in the testosterone- and oxymetholone-treated rats, while the 5-HT synthesis rate was not affected by the AAS-treatments. 4. The MAO-A activity was increased in the oxymetholone-treated rats while the other treatment groups were unaffected. The MAO-B activity was not changed. 5. The results indicate that relatively high doses of AAS increase dopaminergic and 5-hydroxytryptaminergic metabolism in male rat brain, probably due to enhanced turnover in these monaminergic systems.
Action of androgenic steroids on brain neurotransmitters in rats.Vermes I, Várszegi M, Tóth EK, Telegdy G.
The effects of androgenic steroids on the dopamine (DA), noradrenaline (NA) and 5-hydroxytryptamine (5-HT) contents of different brain regions have been studied in order to elucidate the possible involvement of neurotransmitters in the negative feedback action of androgens. Administration of testosterone propionate (TP); (100 micrograms/kg or 5 mg/kg, i.p.) increased plasma testosterones, which reached a maximum at about 30 min following injections. TP (100 micrograms/kg) decreased the DA level in the hypothalamus to a minimum after 30 min and returned to normal level after 120 min. There was no effect in the amygdala, striatum and mesencephalon. Subsequent to 5 mg/kg i.p. TP administration, the minimum in the DA level was observed between 90 and 120 min in the hypothalamus, and after 120 min in the amygdala, but the treatment was without effect in the striatum and mesencephalon. Both doses of TP were ineffective as regards for in altering NA and 5-HT levels in the brain areas studied. In a dose of 5 mg/kg, androgens of different activities, such as norandrostenolone, dihydrostestosterone and androstenedione, decreased the DA contents of the hypothalamus and amygdala regions, but pregnenolone was ineffective. None of the androgens affected the NA and 5-HT levels in the brain areas studied. The data suggest that some of the actions of androgens are mediated via a dopaminergic mechanism in which not only the hypothalamus but also the amygdala is involved.
PMID: 37455 [PubMed - indexed for MEDLINE]
Psychological and serum homovanillic acid changes in men administered androgenic steroids.Hannan CJ Jr, Friedl KE, Zold A, Kettler TM, Plymate SR.
Department of Clinical Investigation, Madigan Army Medical Center, Tacoma, Washington.
We report a difference in the response of serum homovanillic acid (HVA) and in the performance of some psychological tasks before and after the administration of testosterone enanthate (TE, 100 or 300 mg/wk) or nandrolone decanoate (ND, 100 or 300 mg/wk) for 6 wk to healthy men. Serum HVA was significantly increased in both the low- and high-dose ND groups, from 8.4 +/- 1.0 and 8.7 +/- 0.5 pmol/ml (mean +/- SE) to 11.6 +/- 1.7 and 10.7 +/- 1.1 pmol/ml respectively. No significant changes in HVA were observed for the groups administered TE, nor in 5-HIAA for any of the groups. The influence of ND on the dopaminergic system, which is reflected in increased serum HVA, appears to be independent from the psychological effects which were produced by both androgens. The only change in psychomotor test performance was an improvement in the first trial of a pegboard task. All subjects except those receiving ND (100 mg/wk) were significantly more optimistic in the prediction of their own performance for all nondominant hand tasks (pegboard and finger tapping). The "hostility" and "resentment and aggression" subscales of the MMPI increased significantly in all groups, more so in the high-dose groups.
PMID: 1745700 [PubMed - indexed for MEDLINE]
Increased dopaminergic and 5-hydroxytryptaminergic activities in male rat brain following long-term treatment with anabolic androgenic steroids.Thiblin I, Finn A, Ross SB, Stenfors C.
Department of Forensic Medicine, Karolinska Institute, Stockholm, Sweden.
1. The effects of treating groups of rats with four different anabolic androgenic steroids (AAS) (testosterone, nandrolone, methandrostenolone, and oxymetholone) on 5-hydroxytryptamine (5-HT) and dopamine (DA) neurones in different brain regions were examined. The AAS was injected six times with 1 week's interval and the rats were sacrificed 2 days after the final injection. 5-HT and its metabolite 5-hydroxyindoleacetic acid (5-HIAA), DA and its metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) were measured. The effect on DA and 5-HT synthesis rate was analysed as the accumulation of 3,4-dihydroxyphenyl-alanine (DOPA) and 5-hydroxytryptophan (5-HTP), respectively, after inhibition of the amino acid decarboxylase with NSD-1015 (3-hydroxy-benzylhydrazine dihydrochloride). Additionally, the monoamine oxidase (MAO) activity was analysed in the hypothalamus. 2. The DOPAC + HVA/DA ratio was increased in the striatum in all treatment groups. However, the synthesis rate of DA was significantly increased only in the methandrostenolone treated group. 3. The 5-HIAA/5-HT ratio was increased in all treatment groups in the hippocampus, in the frontal cortex in the methandrostenolone-treated animals and in the hypothalamus in the testosterone- and oxymetholone-treated rats, while the 5-HT synthesis rate was not affected by the AAS-treatments. 4. The MAO-A activity was increased in the oxymetholone-treated rats while the other treatment groups were unaffected. The MAO-B activity was not changed. 5. The results indicate that relatively high doses of AAS increase dopaminergic and 5-hydroxytryptaminergic metabolism in male rat brain, probably due to enhanced turnover in these monaminergic systems.
