Not "depression" if anything it makes me feel a little tired after administration so I take it before bed.
However, I believe mt2 can upregulate dopamine receptors. Which could cause less dopamine release short term. Long term it could be helpful for overall receptor health though.
"The MT2 receptor is coupled with Gi/o‐type proteins and encoded by the melatonin receptor 1B gene on chromosome 11q21‐q22. It inhibits cyclic guanosine monophosphate formation and decreases calcium-dependent dopamine release in the retina [
103,
109]. Melatonin receptors are studied as neuroprotective drug targets. Melatonin has a neurogenic effect also through MT2 receptors [
110]. Both receptors activate protein kinase C in the SCN and increase phosphorylation of extracellular signal-regulated kinase, which regulates dendritogenesis [
111] and transcription of clock gene expression, such as PER1, and inhibit forskolin-stimulated cyclic adenosine monophosphate production."
I don't know for a fact but I would think this would increase nrem sleep. Possibly why it causes some to be tired, especially if on high androgens and your receptors are being downregulated.
I remember running it on tren and it helped me sleep.