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PRIMARY CAUSE AND THERAPY FOR PROSTATE CANCER
PART 1 of 2
By Dr. James Howenstine, MD.
March 22, 2007
NewsWithViews.com
The main factor responsible for the rapidly rising incidence of prostate cancer in men and breast cancer and uterine cancer in women appears to be the excessive exposure of modern men and women to estrogen. If testosterone had anything to do with prostate cancer there should be an epidemic of this disease in teenage males. All persons on planet earth are getting, for the first time in history, steady large exposure to estrogen from inhaled fuel exhaust, plastics, estrogen implants in meat and fed to chickens, herbicides, pesticides and propylene glycol.
All disease arises from metabolic imbalance.[1] When the underlying metabolic imbalance is corrected the disease goes away. If you fail to keep up the correction for the underlying metabolic imbalance (i.e. revert back to whatever created the metabolic imbalance in the first place), the disease will come back. This is called preventative medicine. Cancer is no different--it is caused by an underlying metabolic imbalance that turns normal cells into cancer cells.
How Does Excess Estradiol Cause Cancer of Prostate, Breast and Uterus?
Researchers such as Ercole Cavalieri Ph.D., Director of the Eppley Institute for Research in Cancer at the University of Nebraska have learned that a metabolite or byproduct of estradiol and estrone(the two most potent human estrogens) is destructive to adenine and guanine. These two purines along with the pyrimadines cystine and thymine compose the 4 nitrogenous bases of DNA. The diminished production of DNA permits gene mutations that can lead to cancer. Other estrogen metabolites are metabolized in the liver and excreted in the urine. The dangerous metabolite of estradiol and estrone is found most often in people eating more of dangerous transfats, fewer of good fats (extra virgin olive oil, fish oil) and less of sulfur containing amino acids found in beans, garlic, onions, cauliflower, cabbage.
The normal protection against gene mutation involves maintaining good physiologic levels of progesterone and testosterone. Stress increases the cortisol levels which makes the body resistant to other hormones and increases oxidation which is at the heart of how DNA damage is caused by these estrogen metabolites.
Males develop falling levels of testosterone and progesterone as they age. At the same time the level of estradiol is rising producing estrogen dominance in elderly males. Men with low levels of testosterone[2] are at greater risk of developing prostate cancer than men with higher testosterone levels.
Estrogen dominance activates the oncogene Bel-2 while progesterone and testosterone activate the protector gene p53. In laboratory cultures of prostate cancer cells, breast cancer cells and endometrial cancer cells the proliferation of cancer cells is produced by Bel-2 and prevented by p53.
What Causes Estrogen Dominance?
Estrogen dominance causes more cases of cancer of prostate, breast and endometrium than any other cause. Common causes for estrogen dominance include:
Insulin Resistance Males with the highest rates of insulin resistance were compared to males with the best insulin sensitivity. When males with the highest insulin resistance and greatest waist to hip ratios were combined the risk of prostate cancer was increased by 8.21 times.
Stress Cortisol blood levels rise in stress which impairs the action of insulin permitting blood sugar values to rise and insulin to be less effective(insulin resistance).
Obesity accelerates estrogen production in males because fat cells convert testosterone and androsterone into estrogens which stimulates the growth of the prostate gland. Generally the more fat a man carries the higher his estradiol levels will be. To make matters even worse for males the enzyme aromatase converts testosterone to estrogen. This is less likely to occur when testosterone therapy is taken in cream form(compounding pharmacists make this)rather than by injection. This action of aromatase can also be blocked by extract of passion flower plant.
Transfats found in pastries and processed foods promote weight gain, diabetes, arteriosclerosis and cancer
Embryonic Damage[3] Excess estrogen exposure to differentiating cells particularly in the testes and ovaries between days 18 and 23 is common and important. This damage results in delayed puberty and infertility in males and miscarriages, precocious puberty and progesterone lack by age 35 in women.
Xenoestrogen exposure Males working in factories making herbicides have 9X greater incidence of prostate cancer. Exposure to insect sprays, outgassing from carpets, etc in homes also puts estrogen into the body.
Liver Diseases and Alcoholism Impaired metabolism of estrogens leads to excess estrogen and enlarged breasts in males.
Other causes for estrogen dominance include sleep deprivation, working nights in bright lights and trying to sleep in daytime, fluoride exposure from water and toothpaste, environmental estrogens(outgases from carpets and home chemicals), sedentary lifestyle, polluted air(vehicle exhaust) and hypothyroidism.
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