Good post brother. I see that as a "slow bulking" agent you like Primo higher than Test. I also like this use... some guys seem more prone to the "low E2 sides," probably the same guys that just generally might not handle AIs well (a speculation of mine).
I wonder if you can comment on whether your joints usually feel better after a 20 week (give or take) Primo run vs a Tren run, since there's a more gradual rise in loading (sparing joints, tendon/ligaments)? When using it for cutting, what's your dosage? Oh, also, are you on hCG while running the Primo?
Also, just a bit of a nudge for your willingness to use Tren, I can easily argue that for someone that's resilient to the lipid derangement and such from Tren, Tren is a harm reduction compound (use less [perhaps even skipping an oral like var], run shorter, less "area under the curve.") Tren definitely does some things that are unique (e.g., increased insulin sensitivity via reduced PPARγ number [anti-adipogenic]) versus Primo's likely sharing reduced estrogen uptake into some tissues similar to Mast.
I love primo as slow bulking/recomp or cut. General fitness works too. Great compound. I'm largely a 1:1 guy but I'm doing two 3cc injections a week and my test is 250mg/ml, deca is 250mg/ml, and primo is 200mg/ml so it works this way and feels fine as I've run it before but primo always at 600mg. Dosage would be the same. If I was really relying on it to bulk and say running lower test and nothing else...I'd probably need a gram but I'd just assume use deca/test and be done. For my purposes I'm not sure I'd drop under 600mg - I'm also 6'3" and 250ish (can get to 275 but really trying to stay 230-240 and lean out as I think that's a good healthy weight for my frame).
On the E2, I'm doing bloods next week and I'll get you the numbers as I'll be able to determine HDL impact of primo alone vs when I had 200mg of Mast in last year.
When I run 500 test, 600 primo, 200-250 deca, 200 mast my E2 Ultra Sensitive was 33 with range </= 29pg/ml so my low HDL of 28 (I generally sit at 36-40 with range >/= 40...stupid genetics nothing ever gets this into 50 or above range).
For reference 200 test and 160 deca puts E2 at 105 on the same test, hence I usually run an AI. So definitely primo is having an effect on E2 for me. HDL was 36 here. I've run 750 test and 600 deca with no HDL hit either.
What we will see on current 500 test, 600 primo, and 250 deca with no mast is isolating primo impact on E2 and HDL. I suspect primo hits HDL (my LDL is fine and even improved on it) as I've seen others mention this in their bloods the more I've looked. I know you asked me for it at one point, so I'll loop back with you as we're almost there.
Joints...it's interesting. I like a low dose deca in there always to just keep lubed and lower wear and tear. Doesn't heal but promotes a healing environment and I've successfully used it for that purpose a huge number of times over 30 years. That said, I'd been having some real issues on my left shoulder where my rehab/prehab just did nothing for effectiveness. I've had multiple dislocations and some minor tears so I know the shoulder deal. At some point last summer during the primo run, it went away after over a year of pain/discomfort and I never noticed it getting better. Crazy. I'll say that tren does not help me here and if anything makes joints worse as it pulls fluids from my body. This is both good/bad as my blood pressure issues are driven by water retention so I'm blessed that tren seems to actually reduce my blood pressure.
I have a load of tren as a buddy messed up on a big order and we had double the original large amount so I'm set for years. I'll use it again but bloods outside of lipids and liver go a bit wild too. It's one of those things where I know and can feel major stuff happening in my body and I've gotten way too many panels with flags all over them in odd places. Doesn't "feel" healthy and bloods don't come out "healthy". I get no sides other than some sleep issues if I don't scale up a bit. I do plan to run lower dose like 150mg tren a or 200mg of tren e as a 3rd compound on a bulk or just for short periods to break through a plateau.
This is obviously an N=1 thing but some numbers behind it, a good amount of experience for anecdote, and maybe this stuff helps a bit so happy to share and help others.