Receptor Clearing

[alecaf]

Just wondering what the best way to clear one's receptor post cycle. I understand that this is crucial to getting good gains for the next cycle. I've read a couple of articles on it and it seems that the best way is too speed metabolic rate with t3 or clen. However i'm still uncertain and would like to kow you guy's opinions on this.

 

[alecaf]

thanks D, It makes sense.

 

[oldfella]

I agree with dad, but in a simple answer just have some time off of gear!! Your receptors can never be cleared, otherwise how in hell would we ever realize any hormones in our bodies. But you can give them a break from heavy bombardment!

 

[alecaf]

I just read an article about it on isteroids. It didn't seem legit enought for me to believe it since it was an uknown who wrote it but i apreciate your input. I guess its one of the things we want to believe because of its convinience to our lifestyle lol. But yeah the evidence shown in this article is no scientific at all. http://www.isteroids.com/steroids/Steroid Receptor Clearing.html

 

[Ashop]

I just read an old article in GEAR UZR magazine about receptor clearing. I'll look back at it and see what it says.

 

[Ashop]

While yuo're at it, see if it's got any references or if it's just some "guru's" opinion with no legitimate scientific support.

it was written by trevor smith. I highly doubt that there is any scientific proof. i doubt anyone would fund a study on this.

 

[GoneForever]

I read somewhere that DNP will clear receptors or some bullshit and makes your gains much better on next cycle. A risk im not willing to take.

 

[speedbacker]

it was written by trevor smith. I highly doubt that there is any scientific proof. i doubt anyone would fund a study on this.

Yea, here's the article:

Steroid receptor clearing

By Trevor L. Smith

A lot has been said in regards to clearing the receptors and I thought now would be a good time to delve into this subject and simplify things.

Basically, one must view the receptor sites as parking spaces.

Envision a slew of parking spaces that are all empty. Now we are going to call these parking spaces your receptor sites and we shall call steroids the cars. Now I want you to imagine one of those old 1950's style drive up hamburger stands where the girls come up in roller skates and take your order. Typically one would order a burger, fries and a coke--ah the food of the gods--the waitress would take the order, go bring the information to the cook, who would in-turn make the food and the waitress would then bring the food to you and you would then begin eating which is the whole reason you came to the hamburger stand in the first place.

I think everyone can easily understand that. Which means everyone can easily understand all they need to know about the receptor sites because they do the exact same thing. We will keep with this hamburger stand model and explain what happens when you inject steroids

Remember how I said steroids were like the cars and the parking spaces were like the receptor sites? Well it is basically that simple. When you inject testosterone or any one of it's anabolic or androgenic derivatives, you are sending a whole slew of "cars" into your system. Now these "cars" are on a mission--just like you would be if you were hungry and heading to a hamburger stand. They have orders to place with the cells, but before they can place them they must first find a parking space.

Now let's say you have never used steroids before. If this were the case, it would be very much like a hamburger stand that was having a grand opening....lots and lots of empty parking spaces waiting for cars to fill them up and place their orders. The steroids (cars) enter the system and come to a brand new hamburger stand called your cells. Now these cells have never previously been open to the boat-load of anabolics that are now present in the system because they previously only dealt with what your body naturally produced. However, there are lots of extra parking spaces that can be utilized and so the steroids park themselves into these spaces.

Once they are parked a "waitress" called CYCLICl AMP literally crosses the cellular membrane which is totally impenetrably to anything else and takes the order from the steroid. The order is quite simple: Build More Muscle!!

The "waitress" then crosses back through the cellular membrane and brings the order to the "cook" called the Nucleus who begins to fill it by ordering its helpers called Ribosomes to produce muscle protein.. Now different steroids will have slightly different orders in that some may have a bigger order for the cook to fill--such as testosterone. The thing you have to realize is that a lot of times, after the order is placed, the steroid does not necessarily leave the parking space and make it available to other steroids.....it will often sit in the parking space even though it is no longer sending orders to the "waitress" to bring to the "cook", and this is where the problem of "DOWN-REGULATION" comes in. You see even if you send in more and more fresh new "cars" to occupy the receptor spaces, if they are already taken up by old "dead cars" you are shit out of luck.....

This is why you do not continually grow by injecting bigger and bigger doses of steroids. THERE ARE A LIMITED NUMBER OF PARKING SPACES. Now it would not be so bad if all the parking spaces were taken by "cars" that were sending orders to the cook, because that is when you grow. The problem is when there are "cars" that are no longer sending orders and on top of that have dead batteries which is preventing them from exiting the receptors parking space.

This is what the whole point of this article is....TOWING AWAY ALL THE DEAD "CARS" FROM THE RECEPTOR SITES PARKING SPACES AS TO FREE THEM UP FOR NEW, FRESH, HUNGRY "CARS" TO OCCUPY THEM...This will result in new muscle mass!

O.K. Trevor, I am with you so far, but what the f*** can I do about it?

The answer is ...PLENTY!

First and foremost, is to plan sensible courses. This is why I am an advocate of short courses designed in such a fashion as to have all drugs out of the system by the end of the cycle and then allow for a 3-4 week off time in which you are totally clean. If you stay on these monster 4-6 month courses, you just wind up screwing yourself and requiring that much longer of an off period. The longer you are on, the more the body recognizes that there is "too much" in the system and will begin to take counter measures. And the longer you are on, the more "dead cars" you will have sitting in the receptor parking spaces which means NO MORE GROWING!

Now with this in mind, how can we help get the cars out of there?

Well WE actually cannot, but the body can and will. Basically as time goes by, the body will free up the parking spaces just like a tow truck would remove a dead car from a parking space. However, you are at the mercy of time in this situation which is why it is important to utilize short courses that will cause less disturbance in the system, less "dead cars" in the receptor spaces and therefore less time needed for the body to remove them and free up the spaces.

That being said, it should be noted that even short course will pile up "dead cars" after a while and you should give yourself an extended clean out of 2 months at least once a year.

But Trevor, isn't there anything I can do to help speed the process?

Once again the answer is yes!

You can help speed the process up dramatically by increasing your metabolic rate...Speeding up the metabolic rate is akin to hiring extra tow trucks to clear out all those "dead cars" that are occupying the receptor sites!

Have you ever know a person who was much, much fatter than you and yet ate half as much?

These poor bastards think they were given the genetic shaft and try every diet fad imaginable only to stay fat. Their problem no longer lies in their eating habits--which is ironic--; it lies in their metabolism, which basically was shut down due to the excess eating and lack of exercise that got them fat in the first place. Once you understand this, you can easily control your weight for the rest of your life. But what the f*** does this have to due with steroid receptor sites?

EVERYTHING!

The same thing I would prescribe someone whose metabolism has shut down due to obesity, is the same thing I would prescribe someone who's receptor sites are all clogged and is no longer making progress....INCREASE THE METABOLIC RATE!!

Below I will outline a few ways this can be achieved in the constraints of a 4 week Receptor Clearing Cycle follwing the completion of a Muscle Building Course using anabolics:

Diet: I suggest cutting back 300 calories below maintenance per day during a 4 week off time from your anabolic regime...I also suggest eating 6-8 small meals spread out from early morning to late at night. The higher the number of meals you eat, the more your body has to go to work and break down the food which causes the metabolic rate to increase.

Aerobics: Yet another tool in the battle to increase the metabolism, I would suggest low level aerobics 5 times per week 30 minutes per session.

Pharmacology: It is important that one does not have ANY anabolics that are active in the system during this time period.....make sure that you have had a good 4 weeks since your last shot of long acting compound before you embark on this 4 week receptor clearing cycle....otherwise you are wasting your fucking time! That being said, I would suggest the use of the following compounds to help accelerate the Receptor Clearing Process:



1. D.N.P. -- Understand that this is a fucking vicious poison and a component in T.N.T., and I do not suggest it's use at all, but to be fair I must admit that NOTHING can raise the metabolic rate like D.N.P. can. Because this is well known, there are many people that will want to try it...This being the case, D.N.P. should only be used in the following manner during this course: 3 days on, 4 days off at a dose of 4mg per kilogram of bodyweight taken before bed----have plenty of towels around and a fan to keep you cool!

2. Cytomel--T3 is another booster of metabolic rate which is why the fitness models live on this stuff...it keeps you engines running high and burns the fat right off....In this case, we are more concerned with the fact that it increases the metabolic rate. Suggested use is 75mcg -100mcg 5 days on 2 days off for the 4 week course

* If you do not wish to use D.N.P.---which I think is the smarter approach as it is very dangerous.

There you have it...a brief simple lesson on your receptors and how you might go about keeping them free and clear so you can continue to Grow, Grow, Grow and they begin to go to work.

 

[speedbacker]

I read somewhere that DNP will clear receptors or some bullshit and makes your gains much better on next cycle. A risk im not willing to take.

Yea pgf2a is said to supposedly have this effect as well. Author L Rea has written quite a bit about it in his books.

 

[alecaf]

yeah bro thats the article i was talkin about. Its interesting but like dad said, no scientific proof.

 

[bluto]

The "bridgers"

This guy at the gym who hasnt grown a inch in years told me today he was clearing his "test" receptors by "only" using 1200mg of EQ per week, told me he was gonna blow up when he got back on test.

I really dont know what to say to people like that. I always figured it was on or off, the whole idea of bridging seems crazy to me.

 

[maxititer]

That is quite outdated conception about receptors cleaning. Receptors or expressed or not expressed. Each molecules of testosterone can acts on only one receptor and only once. When it happens they are both done. There is no way to activate same receptor twice.

In fact it is just opposite, such steroids as oxandrolon for example, increasing number of expressed androgen receptors in skeletal muscle.

 

[insaned]

That is quite outdated conception about receptors cleaning. Receptors or expressed or not expressed. Each molecules of testosterone can acts on only one receptor and only once. When it happens they are both done. There is no way to activate same receptor twice.

In fact it is just opposite, such steroids as oxandrolon for example, increasing number of expressed androgen receptors in skeletal muscle.

Most of the steroid hormones have intracellular receptor proteins (other will have membrane..) for each specific signal, altough if you take testosterone signal as example you will have a lot of receptors for them, and they will bind only to one receptor at a time, when they will bind they will activate the protein that will start the transduction and after the activated complex has done his work in the cell nucleus (transcription activation) it can release the signal again, and that signal can bind to another receptor, at the same cell or in another cell eventually! The frequence of this process or the duration of it, is somewhat not well studied yet.

Such thing as "cleaning" receptors makes no sense. The only thing that makes sense would be incresing cell number, thus increasing receptor proteins and that leading to more activated complexes "working" in the body.

 

[maxititer]

Short-term oxandrolone administration stimulates net muscle protein synthesis in young men. Journal of Clinical Endocrinology and Metabolism 84 2705–2711.

http://jcem.endojournals.org/cgi/content/full/84/8/2705

and
more recent and very rare study of large number of gene expression influenced by androgens

Tetrahydrogestrinone induces a genomic signature typical of a potent anabolic steroid

**broken link removed**

 

[maxititer]

Most of the steroid hormones have intracellular receptor proteins (other will have membrane..) for each specific signal, altough if you take testosterone signal as example you will have a lot of receptors for them, and they will bind only to one receptor at a time, when they will bind they will activate the protein that will start the transduction and after the activated complex has done his work in the cell nucleus (transcription activation) it can release the signal again, and that signal can bind to another receptor, at the same cell or in another cell eventually! The frequence of this process or the duration of it, is somewhat not well studied yet.

Such thing as "cleaning" receptors makes no sense. The only thing that makes sense would be incresing cell number, thus increasing receptor proteins and that leading to more activated complexes "working" in the body.

you are right, brother, but those ideas about receptor's cleaning, will be around for next 10-20 years, it was copy/pasted in great number all over internet and better be carefull, you can banned, some time, some where.

 

[BigYNY]

i would stay away from T3 post cycle, it is very catabolic

 

[maxititer]

The key factor for androgens stimulated muscle hypertrophy appears to be the satellite cells. Under influence of androgens satellite cells dividing twice faster.

In such situation two factors will play most important role, number of CD34 cells with CXR4 receptor released from bone marrow (can be increased by use of GM-CSF) and space available or not in trained muscles. If no space satellite cells will simply die. Key factor which can provide free space and stimulate proliferation of satellite cells is MGF. b/c one of very important role of MGF is in modulation of fibrinolitic enzymes in trained muscle.

http://joe.endocrinology-journals.org/cgi/reprint/191/2/349.pdf

 

[PHIL HERNON]

NICE

The key factor for androgens stimulated muscle hypertrophy appears to be the satellite cells. Under influence of androgens satellite cells dividing twice faster.

In such situation two factors will play most important role, number of CD34 cells with CXR4 receptor released from bone marrow (can be increased by use of GM-CSF) and space available or not in trained muscles. If no space satellite cells will simply die. Key factor which can provide free space and stimulate proliferation of satellite cells is MGF. b/c one of very important role of MGF is in modulation of fibrinolitic enzymes in trained muscle.

**broken link removed**

THANKS FOR COMING HERE AND BRINGING YOUR KNOWLEDGE!!

 

[maxititer]

Interesting - thanks!
So what do yuo suppose the limiting factor is then? At some point this mechanism must become less responsive as we don't (yet) have 400 lb BBer's.

Still not sure how this answers the receptor clearing/upregulation issue though.

I assume that concept about over saturated receptors was brought up to the light with purpose to explain,
some kind of plateau situation when AAS did not works so well as it was before.
Obviously this explanation is not so correct, and some other limiting factors are there.

imo here two main factors, which can make muscle unresponsive to androgen stimulation:

- cells density in that muscle too too high, and muscle architecture cannot change overnight. It need time and modulation of
fibrinolitic enzymes secreted locally is muscle. Therefore MGF, I would consider as most potent drug for local growth, b/c only MGF can
stimulate both, proliferation of muscle satellite cells and change muscle architecture by modulating fibrinolitic enzymes system.

Try to inject in large muscle group bilaterally with 400 mcg of PEG MGF EOD for one week.
Any lagging muscle group will respond, with sufficient amount of protein in diet. That, I would consider as a concept
prove of importance of modulation of fibrinolitic enzymes system for changing muscle architecture.

- second limiting factor is amount of satellite cells grafted into the trained muscle. The idea of "no free space no grafting", again points toward importance of MGF. But amount of stem cells released from bone marrow during training plays very importnat role on its own.

All androgens and growth factor can only
act via satellite cells, then obviously more satellite cells presented at that moment better will be response fro drugs.
The use of GM-CSF PWO can increase number of stem cells homed in exactly those muscle which where trained.

During training a lot of very well communicated events happening, with one purpose compensation and recovery of muscles.
It is so well communicated events, different receptors expressed , different growth factors secreted, myostatin suppressed etc.
One example: during training bone marrow releasing CD34 cells, not just any kind of CD34 cells, but those cells,
which released from bone marrow during training expressing CXR4 receptor. Means those cells released from bone marrow,
with one purpose to regenerate muscles, and not any muscles, but exactly those which were trained, because CXR4 receptor is receptor
for SDF-1 (stromal cell derived factor), which expressed during training in in those muscles which were trained.
SDF-1 expressed during training and because of it CD34 cells with CXR4 receptor will get new home exactly in this place.
Why it happen during weight lifting, and not during marathon running, because expression of SDF-1 regulated
by HIF1 hypoxia inducible factor 1, which is in fact is transcription factor for SDF1.

Nerves much more sensitive to hypoxia and they will declare failure much faster then muscles, therefore the use of such drugs like piracetam can be very beneficial with this style of training.

It is one reason, why DC style training works. You can inject 800 mcg MGF and run 30 miles, your muscles will not become bigger.

 

[maldorf]

you certainly make MGF sound better than I thought it was. How would you compare the effects of IGF and HGH to this?