Receptor Saturation?

[getripped]

I was told having adequate time off for my steroid receptors to clean out this will help me get better gain when i hit the next cycle ??

What is Receptor saturation ??

If this thread is un suitable for this sections please move sorry for any inconvenience

 

[sam]

I'll give you an example. If you take 2 aspirins every day after a certain about of time your body will require a larger dose to work. The body adapts.

This is called receptor saturation. Sometimes a step backwards is a larger step forward.

 

[joeshow5]

I'll give you an example. If you take 2 aspirins every day after a certain about of time your body will require a larger dose to work. The body adapts.

This is called receptor saturation. Sometimes a step backwards is a larger step forward.

Not quite. That is more of a tolerance issue.

Imagine the receptor as being a sponge, and the steroid as water. Once the sponge is filled it can't hold more water. Any excess water will go to waste. It is saturated.

 

[OuchThatHurts]

What does this difference in the effects of testosterone and stanozolol mean? It means that stanozolol may increase protein synthesis by binding to AR receptors in existing myonuclei, however, because it does not increase growth factor levels it is much less effective at activating satellite cells and therefore may not increase satellite cell activity nor myonuclear number directly when compared to testosterone esters. I will explain t...........

So how can you copy and paste this article in one thread and then start a thread asking this:

How is it possible that year long steroid cycles can produce gains still when their is steroid receptor burnout? That is, they become so saturated that you stop growing. How do the pros stay on full time and still make gains? I believe my receptors are burned out and the only way to clear them is to go off the gear for a while. Which I really dont want to do haha. Not until the summer is over. Is there any other way to free up my receptors? Switch gear maybe? What do you guys think? I dont know too much about receptors etc. Thanks.

Didn't the article answer your question?

 

[Soulstealer]

http://en.wikipedia.org/wiki/Androgen_receptor

Genomic

The primary mechanism of action for androgen receptors is direct regulation of gene transcription. The binding of an androgen to the androgen receptor results in a conformational change in the receptor which in turn causes dissociation of heat shock proteins, transport from the cytosol into the cell nucleus, and dimerization. The androgen receptor dimer binds to a specific sequence of DNA known as a hormone response element. Androgen receptors interact with other proteins in the nucleus resulting in up or down regulation of specific gene transcription.[10] Up-regulation or activation of transcription results in increased synthesis of messenger RNA which in turn is transcribed by ribosomes to produce specific proteins. One of the known target genes of androgen receptor activation is insulin-like growth factor I (IGF-1).[11] Thus, changes in levels of specific proteins in cells is one way that androgen receptors control cell behavior.

here you go take a read guy saturation or down regulation of androgen receptors is an archaic an ill conceived notion based on beta and alpha down regulation from stimulants infact once an androgen receptor is bound it crosses cellular walls to initiate its action in the nucleus.... heavy androgens have actually been shown to increase the density of androgen receptors per biopsied mass of muscle tissue... the lack of response after a period of time is due to the body doing what it does best... up regulation of catabolic hormones in an attempt to attain homeostasis... in other words

Scenario: You bring yourself from level 1(completely natural) to level 5( 3000ng/dl) of test.... over a period of time the body will compensate by increasing catabolic hormones to match.... the biggest reason for "cruising and blasting"

Hope that help...

 

[PHIL HERNON]

AN EXAMPLE

SAY FOR INSTANCE SOMEONE WORKED THEIR WAY UP TO 1 GRAM TEST PER WEEK ...STAYED THERE FOR 1 YEAR FOR EXAMPLE........ALL OF A SUDDEN THEY WILL NOT GET SMALLER BECAUSE OF SOME "OVER SATURATION"........IF THEY LOWER THE DOSAGE TO SAY 750MG WEEKLY THEY WILL ATROPHY, IF THEY ADD MORE TEST TO SAY 1250MG WEEKLY, THEY WILL EXPERIENCE HYPERTROPHY........

 

[BIG DUB]

SAY FOR INSTANCE SOMEONE WORKED THEIR WAY UP TO 1 GRAM TEST PER WEEK ...STAYED THERE FOR 1 YEAR FOR EXAMPLE........ALL OF A SUDDEN THEY WILL NOT GET SMALLER BECAUSE OF SOME "OVER SATURATION"........IF THEY LOWER THE DOSAGE TO SAY 750MG WEEKLY THEY WILL ATROPHY, IF THEY ADD MORE TEST TO SAY 1250MG WEEKLY, THEY WILL EXPERIENCE HYPERTROPHY........

That looks to have more to do with estrogen conversion giving the appearance of less or moe gains, from the water bloat.

 

[jmull]

That looks to have more to do with estrogen conversion giving the appearance of less or moe gains, from the water bloat.

Are you sure? Listen to this man, he's the biggest person I've ever seen in my life. Do youself a fovor and listen to him.

 

[b-boy]

That looks to have more to do with estrogen conversion giving the appearance of less or moe gains, from the water bloat.

WTF?

hell man no answer is a bad answer cause at least phil has you thinking.. so excuse my smart assness above...LOL

 

[OuchThatHurts]

WTF?

hell man no answer is a bad answer cause at least phil has you thinking.. so excuse my smart assness above...LOL

b-boy, to hell with this POS thread. I wouldn't waste any more time here on this one.