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Study on heart failure and testosterone.

goheavy63

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Testosterone Therapy May Help Men With Heart Failure
MONDAY, Aug. 24 -- Injections of the male hormone testosterone increased blood-pumping ability and heart muscle strength in men with heart failure, Italian researchers report.

"From our study, it appears that testosterone supplementation is useful for both patients with low and normal testosterone levels, although the improvements are greater in those with low levels," said Dr. Ferdinando Iellamo, an assistant professor of internal medicine at the University of Rome Tor Vergata, and lead author of a report in the Sept. 1 issue of the Journal of the American College of Cardiology.

Use of testosterone for heart failure, the progressive loss of the ability to pump blood throughout the body, has been controversial in some cases. About one of every four men with chronic heart failure has evidence of testosterone deficiency, as production of the hormone declines with age. Few studies of testosterone therapy in heart failure have been done in the United States, but several have been reported in Europe.


The Italian study included 70 elderly men with heart failure, all of whom had low testosterone levels. All received standard heart failure therapy, but half also received injections of 1,000 milligrams of long-acting testosterone at the start, and again at six and 12 weeks. A series of examinations -- electrocardiograms, exercise tests and assessments of muscle strength -- showed improvements in the men who received the hormone treatment but not in those who didn't.

It's not possible to specify the timing and dosage of testosterone therapy for men with heart failure, Iellamo said.

"There is no current guideline," he said. "However, our study indicates that long-acting testosterone at the dose and intervals we employed [to date used only in patients with hypogonadism] is safe and well-tolerated in patients with heart failure."

The study was not designed to determine whether testosterone therapy would prolong survival of men with heart failure, Iellamo said. "Future large trials are needed to appropriately evaluate the outcome," he said.

Such a multi-center trial is in the early planning stage, Iellamo noted. Meanwhile, his group is studying the effects of testosterone therapy in women. "Preliminary results seem promising," he added.

Men with heart failure who are tempted to try testosterone therapy on their own should avoid the temptation, he said. "It is absolutely contraindicated that patients choose testosterone, as well as all drugs, on their own," Iellamo said. The warning is especially important for men with high levels of prostate-specific antigen, an indicator of prostate cancer risk, he noted.

"This study confirms our previous finding for a beneficial effect of testosterone in men with moderate chronic heart failure, improving functional exercise capacity and insulin resistance," said Dr. T. Hugh Jones, a consultant endocrinologist at the University of Sheffield in England.

Jones and his colleagues have reported two studies with positive results, one using testosterone injections, the other using a hormone-delivering skin patch.

"Historically, testosterone-replacement therapy has been contraindicated in men with chronic heart failure," Jones said. "This was due to the fluid retention observed with older forms of testosterone preparation. This study, along with our studies, show that testosterone is safe in these patients and has a benefit on the underlying condition."

But the case for testosterone therapy in heart failure is far from proven, he said. "Now, longer-term studies evaluating effects on survival, quality of life and longer-term safety need to be done to establish if this treatment should be used routinely in the treatment of heart failure in men," Jones said.
 

J_Diggs

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Holy hell! Imagine your grandpa getting injected with 1g of Test! Old man grip would be taken to a whole other level!

On a serious note, that's a promising study.
 

KPR

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you know what im wondering is,what about people who are younger?

lets say you have high BP and mabey something like techacardia..

do you think taking moderate doses of test,say 500 mg for 12 weeks would do more harm than good..

hope im not hijacking this thread
 

Philthy

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you know what im wondering is,what about people who are younger?

lets say you have high BP and mabey something like techacardia..

do you think taking moderate doses of test,say 500 mg for 12 weeks would do more harm than good..

hope im not hijacking this thread

500mgs is not moderate.
 

mike ross

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it would do more harm. Please examine why you have high BP in the first place? Lifestyle, nutrition, stress, drug use, hereditary? The study isnt saying dose up on test to cure your heart problems...
 

maldorf

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A healthy dose would be HRT level which is anywhere from 100-150mg/wk tops. That will vastly improve your life and health if you suffer from low test. If nothing is wrong with your test levels then there is NO reason to take test for just health reasons.
 

Kronis.

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Holy hell! Imagine your grandpa getting injected with 1g of Test! Old man grip would be taken to a whole other level!

On a serious note, that's a promising study.

LOL, prob Testosterone Undeconate so it would just put them in a healthy test range.
 

wasp

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don't forget your crit going up, only reason i'm currently going thru pct. to see if my body can bounce back ,my crit was up to 53 even donating every 2 months and on only 100mg a week for 1.5 yrs.............
 

terraj

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Reads like they are using Reandron/Nebido ( Testosterone Undecanoate)1000mg. It is along acting Test, shots are every 3 -4 months, also keeps levels quiet stable.
 

goheavy63

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don't forget your crit going up, only reason i'm currently going thru pct. to see if my body can bounce back ,my crit was up to 53 even donating every 2 months and on only 100mg a week for 1.5 yrs.............

Yeah I think the study should have been longer but at least in the short term it is good news. Maybe cycle on and off hrt but I know the off time would suck.
 

inacloudofchalk

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Is 392ng considered low for a 28 year old? DHT came out BELOW the normal range by 5 points and SHBG at the high end of the range.
 

maldorf

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Is 392ng considered low for a 28 year old? DHT came out BELOW the normal range by 5 points and SHBG at the high end of the range.

IMO its a bit low. I know I feel much better and "normal" when mine is as least 500. Yours though is real close to being "normal". If you just came off a cycle less than 6 months ago I would give it more time because it will probably come up on its own.
 

inacloudofchalk

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IMO its a bit low. I know I feel much better and "normal" when mine is as least 500. Yours though is real close to being "normal". If you just came off a cycle less than 6 months ago I would give it more time because it will probably come up on its own.

well actually ive been off for many years. since 23. just wanted to be natural. but i guess time caught up with me. matter of fact, just 2 years ago i was 542 with a high free T. just dont feel right. feel like i get more heart palpitations now than when i was younger like 19
 

BIG EVIL42

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A healthy dose would be HRT level which is anywhere from 100-150mg/wk tops. That will vastly improve your life and health if you suffer from low test. If nothing is wrong with your test levels then there is NO reason to take test for just health reasons.

Maldorf, I am familiar with your heart history through your threads and am curious about your opinion on something. Do you think a higher dose than HRT (100-150mg/wk) like 500mg per week would offer better blood flow or heart health effects for someone with managed cardiomyopathy after reading the OP's study?
 

maldorf

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Maldorf, I am familiar with your heart history through your threads and am curious about your opinion on something. Do you think a higher dose than HRT (100-150mg/wk) like 500mg per week would offer better blood flow or heart health effects for someone with managed cardiomyopathy after reading the OP's study?

Absolutely not. More isnt always better. With a does that big my hematocrit would be up in the mid 60s! When I was cruising on 350 mg/wk it once got up to 60. If youre going to be on something long term for life it has to be a safe dose and 500mg/wk is not safe especially for someone that had a heart attack and a blood clot. Even on coumadin now I wont chance something like that. Its hard enough keeping my hematcrit below 53 now taking just 100 mg/wk. Blood gets too thick fast. Not only worried about hematocrit, but it also raises the clotting hormones when youre on a dose that high and I found out I have a genetic condition for that.

That study is odd that it dosed only every 6 weeks. If you figure the dosage per week it only averages out to 166 mg/wk which isnt too far off the norm. Im taking 100 now and doing great on it. I guess they used a longer ester than cyp, but even then by the end of the 6 weeks your levels would be way down. Hell, there are big flucuations even when you dose 1/week. I do believe dosing 2-3x per week is probably better but its more hastle and Im doing just fine with 1x.
 
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inacloudofchalk

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I heard that also having low test levels is dangerous too. i dont think 392ng is a dangerous level but still not optimum for the heart either. my dad died of a heart attack at 47 but he also didnt train or eat properly either and was stressed. had to take blood pressure meds. at 28, my blood pressure is normal. just concerned that 392 is low for me. i definitely dont have much of a sex drive either. but other than that, i guess i feel fine.
 

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