T3 with Test

[Sportsfan87]

If taking with test should I expect muscle loss taking 25 mcg of t3?

 

[Sectør]

Why are you taking t3? Does your bloodwork shows your thyroid is deficient or you’re just randomly adding it in?

It’s highly catabolic. Unless you’re deep in prep and your thyroid is slowing down I don’t see why you’d run it

Also depends on your calorie deficit/surplus on if you lose muscle and if so how much. If my thyroid was working fine I wouldn’t take t3 personally

 

[Sportsfan87]

Why are you taking t3? Does your bloodwork shows your thyroid is deficient or you’re just randomly adding it in?

It’s highly catabolic. Unless you’re deep in prep and your thyroid is slowing down I don’t see why you’d run it

Also depends on your calorie deficit/surplus on if you lose muscle and if so how much. If my thyroid was working fine I wouldn’t take t3 personally

Reverse t3 is high and ft3 is low.

 

[Fleezy]

If taking with test should I expect muscle loss taking 25 mcg of t3?

t3 is definitely not as forgiving as say.. clen - when it comes to sparing lean tissue


it's not something that should be used unless it is actually needed - which makes it unique as far as PED's are concerned IMO

 

[Reno911]

This question cannot be answered.

Are you training?
What's your diet like?
How much cardio are you doing?
Are you naturally ectomorphic or more fat?
Are you prone to losing muscle easy?
What is your current emotional and physical stress level?
Are you on any other gear?
Are you active on Grindr or in the Bear community?

 

[Alpha246]

Don't take it with calcium.

 

[KingOfSushi]

If taking with test should I expect muscle loss taking 25 mcg of t3?

Not if you’re doing things correctly

 

[Stewie]

Skeletal-muscle proteolysis (catabolism) from 25mcg of liothyronine in conjunction with testosterone would be extremely unlikely. Suspectfully you're not going into any long-term caloric deficit in the presence of minimal amino acid intake.

 

[KingOfSushi]

Skeletal-muscle proteolysis (catabolism) from 25mcg of liothyronine in conjunction with testosterone would be extremely unlikely. Suspectfully you're not going into any long-term caloric deficit in the presence of minimal amino acid intake.

Not sure if you’ve seen this study stewie, but I figure you may find it interesting.

https://www.researchgate.net/publication/13369267_Testosterone_Administration_Preserves_Protein_Balance_But_Not_Muscle_Strength_during_28_Days_of_Bed_Rest_1

 

[Stewie]

Not sure if you’ve seen this study stewie, but I figure you may find it interesting.

https://www.researchgate.net/publication/13369267_Testosterone_Administration_Preserves_Protein_Balance_But_Not_Muscle_Strength_during_28_Days_of_Bed_Rest_1

Yes I have, and that particular citation has been presented on a few occasions in the past discussing this same topic.

Being mindful matters as well. Obesity and sedentary muscle quality, for lack of better terms differs with different growth factors, inflammatory signaling and myonuclear degradation; vs an individual that's intentionally breaking skeletal muscle tissue down towards accretion.

The primary process of degradation of skeletal muscle tissue is by the ubiquitin-proteasome system (UPS). With obese and sedentary individuals, UPS expression enhances proteolysis. In contrast, individuals that are seeking hypertrophy. UPS is regulated by anabolic signalling through multiple pathways decreasing UPS expression. Either by maintaining or increasing skeletal muscle hypertrophy. This needs to be taken into consideration when differentiating two different categories of individuals.

Dose matters- without the adjuvant use of testosterone.

The effect of T3 and reverse T3 administration on muscle protein catabolism during fasting as measured by 3-methylhistidine excretion - PubMed

Since recent studies have indicated that measurement in urine of the amino acid, 3-methylhistidine, accurately reflects the extent of muscle catabolism, and because it has been suggested that thyroid hormones may influence muscle breakdown, especially during fasting, the effect of T3 and reverse...

pubmed.ncbi.nlm.nih.gov

And there's murine models (taken at face value) that demonstrated in fasting states exogenous T3 preserved skeletal muscle tissue.

 

[Sportsfan87]

Not if you’re doing things correctly

What do you mean if doing things correctly?

 

[qbkilla]

I heard Stan efferding sp? On a podcast say if your hypo and get meds it doesn't increase your bmr a meaningful amount maybe 50-100 cal....but you have energy and move more which amounts to burning many more calories a day

 

[Plusmetic]

Why are you taking t3? Does your bloodwork shows your thyroid is deficient or you’re just randomly adding it in?

It’s highly catabolic. Unless you’re deep in prep and your thyroid is slowing down I don’t see why you’d run it

Also depends on your calorie deficit/surplus on if you lose muscle and if so how much. If my thyroid was working fine I wouldn’t take t3 personally

25 mcg of T3 is a commonly used low dose, but it’s still highly catabolic. It definitely helps with fat loss, but yes – there is always a risk of muscle loss, especially if you’re in a calorie deficit. Test can help offset that to some extent.





From my experience, adding low dose GH during this process really helps preserve lean mass and improve recovery. Just something to consider based on what worked for me

 

[bbxtreme]

Reverse t3 is high and ft3 is low.

Check your cortisol levels and fix your sleep. That’s simply based on the above statement.

 

[MackCoach]

Don’t buy in to the fake posts about it being “catabolic”

Especially if you are poppin’ 40 mcg of Clen a day which is ANTI CATABOLIC

AND GUESS WHAT?

are you using AAS ? Testosterone? They are anti-catabolic

Well now then you don’t need to worry about the “catabolic” effects of t3 lol

Pro BB’ers go up to 200 mcg t3 daily are they small???? Um NO. lol

Wanna get shredded?

Test
An oral
40 mcg Clen
50 mcg t3

Train hard eat clean high protein and BAM you are ready to win the overall at a state level local show if you’ve built enough muscle

Mack

 

[KingOfSushi]

25 mcg of T3 is a commonly used low dose, but it’s still highly catabolic. It definitely helps with fat loss, but yes – there is always a risk of muscle loss, especially if you’re in a calorie deficit. Test can help offset that to some extent.





From my experience, adding low dose GH during this process really helps preserve lean mass and improve recovery. Just something to consider based on what worked for me

What is making you say 25mcg is highly catabolic

 

[KingOfSushi]

Don’t buy in to the fake posts about it being “catabolic”

Especially if you are poppin’ 40 mcg of Clen a day which is ANTI CATABOLIC

AND GUESS WHAT?

are you using AAS ? Testosterone? They are anti-catabolic

Well now then you don’t need to worry about the “catabolic” effects of t3 lol

Pro BB’ers go up to 200 mcg t3 daily are they small???? Um NO. lol

Wanna get shredded?

Test
An oral
40 mcg Clen
50 mcg t3

Train hard eat clean high protein and BAM you are ready to win the overall at a state level local show if you’ve built enough muscle

Mack

Would you be willing to share any results from your clients or yourself with the protocols you share?

 

[Stewie]

What is making you say 25mcg is highly catabolic

Curious minds would like to know this too. By default, being that the average euthyroid individual is producing +/- 30mcg of triiodothyronine daily. This doesn't equate to +/- 55mcg between the combination of the two.

If we take into consideration, dose dependant, exogenous liothyronine is going to put the brakes on TRH secretion; then further limiting TSH secretion to pump out less T4, therefore minimizing T3 conversion; reduction of total T3.

There's more, I'll leave it at that.

 

[bbxtreme]

25 mcg of T3 is a commonly used low dose, but it’s still highly catabolic. It definitely helps with fat loss, but yes – there is always a risk of muscle loss, especially if you’re in a calorie deficit. Test can help offset that to some extent.


From my experience, adding low dose GH during this process really helps preserve lean mass and improve recovery. Just something to consider based on what worked for me

I think where this bro science gets lost in translation is when guys start taking T3 when they don’t need it to further accelerate fat loss.

When you take a medication such as T3 to bring levels back within range there is nothing catabolic about that.

Most of this becomes a moot point in either scenario though with bodybuilders who are eating high protein and running PED’s.

 

[KingOfSushi]

Curious minds would like to know this too. By default, being that the average euthyroid individual is producing +/- 30mcg of triiodothyronine daily. This doesn't equate to +/- 55mcg between the combination of the two.

If we take into consideration, dose dependant, exogenous liothyronine is going to put the brakes on TRH secretion; then further limiting TSH secretion to pump out less T4, therefore minimizing T3 conversion; reduction of total T3.

There's more, I'll leave it at that.

Yeah. I’m on 25mcg year round. Sometimes push up to 30 or 37.5 for cuts. Experience nothing catabolic of the sorts