Depends on your needs. Normally, running 150 weekly or some folks can get away with less. It's really about the molecular weight of hyaluronate in synovial fluid (Fluid in joints). That's what nandrolone does, it modifies the molecular weight, making it heavier, in turn your synovial fluid is thicker and makes for easier gliding. Hence soothing the joints. So for some, 50mg weekly could be enough modification. But I recommend no less than 100 and no more than 200 weekly.